Cibinetide

ChemicalBook > CAS DataBase List > Cibinetide

Product Name: Cibinetide
CAS No.: 1208243-50-8
Chemical Name: Cibinetide
Synonyms: ARA290;Cibinetide;ARA290, >98%;ara290/Poziotinib;ARA209(Cibinetide);Cibinetide Acetate;Cibinetide(ARA-290);ARA-290 (Cibinetide);ARA290,Cibinetide, >98%;WZTIQQBMSJTRBR-MUZUOSMHSA-N
CBNumber: CB63159958
Molecular Formula: C51H84N16O21
Formula Weight: 1257.31
MOL File: 1208243-50-8.mol

Less

Cibinetide Property

Density: 1.56±0.1 g/cm3(Predicted)
pka: 2.90±0.10(Predicted)
form: Solid
color: White to off-white
Sequence: Glp-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser
InChI: InChI=1S/C51H84N16O21/c1-22(2)17-30(47(84)65-32(19-36(53)71)48(85)66-33(20-68)49(86)67-34(21-69)50(87)88)63-40(77)24(5)57-41(78)25(7-6-16-56-51(54)55)59-43(80)29(11-15-39(75)76)62-46(83)31(18-23(3)4)64-45(82)27(8-12-35(52)70)60-44(81)28(10-14-38(73)74)61-42(79)26-9-13-37(72)58-26/h22-34,68-69H,6-21H2,1-5H3,(H2,52,70)(H2,53,71)(H,57,78)(H,58,72)(H,59,80)(H,60,81)(H,61,79)(H,62,83)(H,63,77)(H,64,82)(H,65,84)(H,66,85)(H,67,86)(H,73,74)(H,75,76)(H,87,88)(H4,54,55,56)/t24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-/m0/s1
InChIKey: WZTIQQBMSJTRBR-WYKNNRPVSA-N
SMILES: O=C([C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([C@]([H])(C([H])([H])C([H])([H])C(N([H])[H])=O)N([H])C([C@]([H])(C([H])([H])C([H])([H])C(=O)O[H])N([H])C([C@]1([H])C([H])([H])C([H])([H])C(N1[H])=O)=O)=O)=O)N([H])[C@]([H])(C(N([H])[C@]([H])(C(N([H])[C@@]([H])(C([H])([H])[H])C(N([H])[C@]([H])(C(N([H])[C@]([H])(C(N([H])[C@]([H])(C(N([H])[C@]([H])(C(=O)O[H])C([H])([H])O[H])=O)C([H])([H])O[H])=O)C([H])([H])C(N([H])[H])=O)=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=O)=O)C([H])([H])C([H])([H])C([H])([H])/N=C(\N([H])[H])/N([H])[H])=O)C([H])([H])C([H])([H])C(=O)O[H]

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb611396
Product name: ARA-290
Packaging: 5mg
Price: $1043.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611396
Product name: ARA-290
Packaging: 10mg
Price: $1802
Updated: 2021/12/16

DC Chemicals

Product number: DC22493
Product name: ARA-290(Cibinetide)
Purity: >98%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

Less

Cibinetide Chemical Properties,Usage,Production

Description

Cibinetide, also known as ARA-290, is a synthetic 11-mer peptide that binds the tissue-protective receptor. ARA290 inhibits high glucose-induced apoptosis of NRK-52E cells. Cibinetide Protects Isolated Human Islets in a Stressful Environment and Improves Engraftment in the Perspective of Intra Portal Islet Transplantation. Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain. ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: Integration between immune system and nociception.

benefits

Cibinetide, also known as ARA 290 and helix B surface peptide (HBSP), is a synthetic 11 amino acid peptide derived from the structure of the B helix of erythropoietin(EPO), with marked anti-apoptotic, anti-inflammatory and anti-permeability effects, recapitulating the effects of the endogenous EPO. Unlike EPO, is not haematopoietic and, thus, is free of the possible side effects of EPO, which can be life threatening. In an experimental model of DR, cibinetide administered systemically inhibited vascular leakage and edema and protected against retinal blood vessels and neuroglial degeneration. Additionally, cibinetide improved metabolic control in both preclinical and clinical studies[7].

Biological Activity

Cibinetide (ARA 290) is an engineered peptide that mimics the 3 dimensional structure of the helix B surface domain of erythropoietin (EPO). It is designed to bind selectively to the non-hematopoietic EPO receptor (sometimes referred to as the innate repair receptor or IRR), that is believed to be a heterodimer of EPOR and the cytokine family beta common receptor (βCR, CD131). Non-hematopoietic EPO ligands have potential tissue protective and anti-inflammatory actions. The IRR is suggested to be a point of integration between the immune system and pain signalling (via nociception) .

in vitro

Cibinetide (ARA290) enhances the proliferation, migration, and resistance to H2O2-induced apoptosis of endothelial colony-forming cells (ECFCs)[1]. Cibinetide (ARA290) is an EPO-analog peptide without hematopoietic side-effects but may have neurotrophic and antidepressant effects.

in vivo

After ECFC transplantation to mice with CLI, a single Cibinetide (ARA290) injection enhances the ischemic/non-ischemic ratio of hindlimb blood flow and capillary density after 28 days and the homing of radiolabeled transplanted cells to the ischemic leg 4?h after transplantation. Cibinetide (ARA290; 30 μg/kg, s.c.) prevents progressive worsening of glucose control without affecting the body weight of rats. Cibinetide significantly decreases glucose AUCs in IPGTT in GK rats. Low-dosage Cibinetide (35 μg/kg, i.p.) treatment slightly attenuates the EAE severity in rats. Cibinetide-treating group (70 μg/kg, i.p.) significantly delays the onset, decreases the neurologic severity, and shortens the duration of EAE in a dose-dependent way.

References

[1] YAOMING. Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand.[J]. Transplantation, 2020. DOI:10.1097/TP.0000000000003284.
[2] AWIDAZAMZAM. The Non-Erythropoietic EPO Analogue Cibinetide Inhibits Osteoclastogenesis In Vitro and Increases Bone Mineral Density in Mice.[J]. International Journal of Molecular Sciences, 2021. DOI:10.3390/ijms23010055.
[3] LOISNOEMI. A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema.[J]. Journal of Clinical Medicine, 2020. DOI:10.3390/jcm9072225.
[4] NAIRZMANFRED. Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis.[J]. Scientific Reports, 2017. DOI:10.1038/s41598-017-13046-3.
[5] BRINESMICHAEL CeramiAnthony. The receptor that tames the innate immune response.[J]. Molecular Medicine, 2012. DOI:10.2119/molmed.2011.00414.
[6] BRINESMICHAEL CeramiAnthony. Erythropoietin and engineered innate repair activators.[J]. Methods in molecular biology, 2013. DOI:10.1007/978-1-62703-308-4_1.
[7] Noemi Lois. “A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema.” Journal of Clinical Medicine (2020).

Cibinetide Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Cibinetide Suppliers

China 109 United States 5 Global 114

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Fax: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 6968
Advantage: 58

Sichuan Taihui Biotechnology Co., Ltd

Tel: 028-87189093 18599944286
Email: 272503470@qq.com
Country: China
ProdList: 99
Advantage: 58

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Fax: 0551-65326641
Email: info@cellmano.com
Country: China
ProdList: 1011
Advantage: 55

Sichuan Takele Biotechnology Co., Ltd.

Tel: +86-028-64348587 15680781153
Email: sales@takelepeptide.com
Country: China
ProdList: 86
Advantage: 58

Nanjing Yuanpeptide Biotech Co.，Ltd.

Tel: 18168071971
Email: support@yuan-peptide.com
Country: China
ProdList: 2980
Advantage: 58

Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd

Tel: 13770887460
Email: wenxi@jszkhy.com
Country: China
ProdList: 1351
Advantage: 58

Hubei Zhaoke BIO-CHEMICAL Co., Ltd.

Tel: 18271904430
Email: 1070737105@qq.com
Country: China
ProdList: 217
Advantage: 58

Guangdong Tuoyuan Biotechnology

Tel: 13593819282
Email: 1721167903@qq.com
Country: China
ProdList: 28
Advantage: 58

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Hangzhou Peptide Biochem Co.,Ltd

Tel: 0571-89197072; 18668118770
Fax: 0571-89197072
Email: linda@peptide-china.com
Country: China
ProdList: 248
Advantage: 56

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303 +86-17380623303
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4813
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83778895 18602735115
Fax: 027-51119224
Email: 18602735115@163.com
Country: China
ProdList: 1998
Advantage: 64

Sichuan Jisheng Biopharmaceutical Co.,Ltd.

Tel: +86-0833-2598983 +86-18086877136
Fax: +86-833-2598903
Email: Nyx-peptide@jsjpharm.cn
Country: China
ProdList: 309
Advantage: 58

Shanghai UCHEM Inc.

Tel: +862156762820 +86-13564624040
Email: sales@myuchem.com
Country: China
ProdList: 7629
Advantage: 58

Shanghai Yunao International Trade Co., Ltd

Tel: +8617621705551
Email: asdf@shanghaihg.cn
Country: China
ProdList: 264
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 0571-88211921
Email: sales1@gotopbio.com
Country: CHINA
ProdList: 2609
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 8913
Advantage: 58

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Fax: 0551-65326641
Email: info@cellmano.com
Country: China
ProdList: 999
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29811
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569266 15319487004
Fax: 029-88380327
Email: 1015@dideu.com
Country: China
ProdList: 3942
Advantage: 58

Nanjing chengqimei Biotechnology Co., Ltd

Tel: 19850819832
Email: 2173594524@qq.com
Country: China
ProdList: 2638
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Xi'an Lyna Bio-Tech Co., Ltd.

Tel: 029-84161958 18629577295
Fax: 029-84161958
Email: magic@lynabio.com
Country: China
ProdList: 1062
Advantage: 55

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Wuhan Dingxintong Pharmaceutical Co. , Ltd.

Tel: 027-52344656 15871722230
Fax: 2796190295
Email: 15871722230@163.com
Country: China
ProdList: 4907
Advantage: 58

Wuhan Wiseman Bioengineering Co.,Ltd

Tel: 027-59506022 13419526507
Fax: 027-59506022
Email: 13419526507@163.com
Country: China
ProdList: 2991
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 0571-88211921 13735575465
Email: sales1@gotopbio.com
Country: China
ProdList: 2890
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7977
Advantage: 58

Shanghai tingchong biology science and technology co., ltd

Tel: 18964309092 18964309092
Email: 2769493375@qq.com
Country: China
ProdList: 2634
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: 0755-66853366; 13670046396
Email: ORDERS@QCSRM.COM
Country: China
ProdList: 24342
Advantage: 58

Wuhan DKY Technology Co.,Ltd.

Tel: 027-81302411 15377658509
Email: zs@dkybpc.com
Country: China
ProdList: 2208
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Chengdu Jinglin Biotechnology Co., Ltd.

Tel: 17711399154
Email: 3211919385@qq.com
Country: China
ProdList: 1815
Advantage: 58

Shaoxing Junyu Biotechnology Co., LTD

Tel: 0571-88211921 15572296305
Email: sales4@gotopbio.com
Country: China
ProdList: 5178
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9956
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Tel: 0571-87213919 17306812703
Email: 3007955328@qq.com
Country: China
ProdList: 6659
Advantage: 58

Hubei Wanye Zhongcheng Chemical Reagent Co., Ltd.

Tel: 18671296875 18671296875
Email: 1205035102@qq.com
Country: China
ProdList: 4302
Advantage: 58

Hangzhou Yijing Technology Co., Ltd

Tel: 15068777134
Email: 1289372011@qq.com
Country: China
ProdList: 207
Advantage: 58

Combio (Suzhou) Ltd.

Tel: 0512-51886999 17706251929
Email: office@combiosz.com
Country: China
ProdList: 2981
Advantage: 58

Wuhan DingCheng Biochemical Co.Ltd

Tel: 13545255233 13545255233
Email: 2851686513@qq.com
Country: China
ProdList: 913
Advantage: 58

Nanjing Yushengkang Biotechnology Co., Ltd

Tel: 13327808530
Email: 2670965693@qq.com
Country: China
ProdList: 2179
Advantage: 58

Zhejiang Jiekun Biotechnology Co., Ltd

Tel: 0571-88211951 13735575465
Email: sales1@gotopbio.com
Country: China
ProdList: 4904
Advantage: 58

Guangzhou Xinyanze Biotechnology Co., LTD

Tel: 18120340188
Email: 3239311947@qq.com
Country: China
ProdList: 278
Advantage: 58

Taiyuan Bailihengkang Biotechnology Co., Ltd

Tel: 19135651983 19135651983
Email: 18611134419@163.com
Country: China
ProdList: 4416
Advantage: 58

Less

View Lastest Price from Cibinetide manufacturers

Hebei Jiafan Trading Company Limited

Product: Ara-290 1208243-50-8
Price: US $5.00/Box
Min. Order: 1Box
Purity: 99.99%
Supply Ability: 20000 boxes
Release date: 2024-12-12

hebei hongtan Biotechnology Co., Ltd

Product: ARA290(Cibinetide) 1208243-50-8
Price: US $30.00/box
Min. Order: 1box
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-03-21

Shandong Huizhihan Supply Chain Co., Ltd

Product: Ara-290 1208243-50-8
Price: US $0.00-0.00/BOX
Min. Order: 1BOX
Purity: 99.99%
Supply Ability: 1000
Release date: 2024-10-31

1208243-50-8, CibinetideRelated Search:

H-SER-ILE-LYS-VAL-ALA-VAL-OH Kisspeptin 10 (human) Hexapeptide 9 cilengitide PalMitoyl Tripeptide-1 Glutathione Irofulven glucagon-like peptide 1 Palmitoyl Hexapeptide-12 Acetyl Dipeptide-1 cetyl ester IRL-1620 Hexapeptide-11 DERMASEPTIN PHYLLOMEDUSA SAUVAGII

ARA-290 (Cibinetide)

ARA290, >98%

ARA290,Cibinetide, >98%

ARA290

WZTIQQBMSJTRBR-MUZUOSMHSA-N

ara290/Poziotinib

L-Serine, 5-oxo-L-prolyl-L-α-glutamyl-L-glutaminyl-L-leucyl-L-α-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-

ARA-290(Cibinetide) acetate

Poziotinib、Cibinetide、ARA-290

inhibit,ARA 290,Cibinetide,Inhibitor,ARA-290

ARA209(Cibinetide)

Cibinetide Acetate

Cibinetide

Cibinetide(ARA-290)

1208243-50-8

1208243-50-7

C51H84N16O21