Irofulven
- Product Name
- Irofulven
- CAS No.
- 920014-72-8
- Chemical Name
- Irofulven
- Synonyms
- RM-493;BIM-22493;IRC-022493);Setmelanodide;Sermelanotide;Setmelanotide (RM-493);RM-493; BIM-22493; IRC-022493);Setmelanotide (RM-493) trifluoroacetate salt;Ac-Arg-c(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2;L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2→8)-disulfide
- CBNumber
- CB63159918
- Molecular Formula
- C49H68N18O9S2
- Formula Weight
- 1117.32
- MOL File
- 920014-72-8.mol
Irofulven Property
- Density
- 1.54±0.1 g/cm3(Predicted)
- pka
- 12.82±0.70(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Ac-Arg-Cys-D-Ala-His-D-Phe-Arg-Trp-Cys-NH2(Disulfide bond)
- InChIKey
- HDHDTKMUACZDAA-JFHGRQLZNA-N
N-Bromosuccinimide Price
- Product number
- DC10323
- Product name
- Setmelanotide
- Purity
- >98%
- Packaging
- 1g
- Price
- $2100
- Updated
- 2021/12/16
Irofulven Chemical Properties,Usage,Production
Uses
Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively[1].
in vivo
Inhibition of refeeding after an overnight fast by Setmelanotide is dependent on functional MC4R, and does not require MC3R. BIM-22493 acutely improves glucose homeostasis. Lepob/Lepob mice treated with BIM-22493 exhibits significantly improved glucose clearance when compared to controls. Chronic BIM-22493 treatment was associated with significantly lower levels of serum glucose and HOMA-IR values[1].
Treatment with setmelanotide results in transient decreases in food intake (35%), with persistent weight loss over 8 weeks of treatment (13.5%) in a diet-induced obese nonhuman primate model[2].
References
[1] Kumar KG, et al. Analysis of the therapeutic functions of novel melanocortin receptor agonists in MC3R- and MC4R-deficient C57BL/6J mice. Peptides. 2009 Oct;30(10):1892-900. DOI:10.1016/j.peptides.2009.07.012
[2] Kievit P, et al. Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes. 2013 Feb;62(2):490-7. DOI:10.2337/db12-0598
Irofulven Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Irofulven manufacturers
- Product
- Setmelanotide 920014-72-8
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-29
- Product
- Irofulven 920014-72-8
- Price
- US $1.00-1.00/kg
- Min. Order
- 0.0001kg
- Purity
- 99%
- Supply Ability
- 50kg
- Release date
- 2025-01-01
- Product
- Setmelanotide 920014-72-8
- Price
- US $12.00/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100KG
- Release date
- 2025-02-26