Afzelin
- Product Name
- Afzelin
- CAS No.
- 482-39-3
- Chemical Name
- Afzelin
- Synonyms
- AFZELIN;KaeMpferin;KAEMPFEROL 3-O-RHAMNOSIDE;Afzeloside;Kaempferol 3-rhamnoside;Kaempferol 3-rhamnoside-RM;Kaempferol 3-O-α-L-Rhamnoside;KAEMPFEROL 3-O-GLUCORHAMNOSIDE;KAEMPFERIN; KAEMPFEROL-3-RHAMNOSIDE;Afzelin/Kaempferol 3-o-glucorhamnoside
- CBNumber
- CB6321426
- Molecular Formula
- C21H20O10
- Formula Weight
- 432.38
- MOL File
- 482-39-3.mol
Afzelin Property
- Melting point:
- 172-174 °C (decomp)(Solv: water (7732-18-5))
- Boiling point:
- 765.6±60.0 °C(Predicted)
- Density
- 1.70±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in methan
- form
- powder
- pka
- 6.20±0.40(Predicted)
- color
- Yellow
N-Bromosuccinimide Price
- Product number
- 300520
- Product name
- Kaempferin
- Packaging
- 10mg
- Price
- $433
- Updated
- 2021/12/16
- Product number
- K100005
- Product name
- Kaempferol3-O-α-L-Rhamnoside
- Packaging
- 25mg
- Price
- $1540
- Updated
- 2021/12/16
- Product number
- W1662
- Product name
- Afzelin
- Packaging
- 5mg
- Price
- $725
- Updated
- 2021/12/16
- Product number
- FK72069
- Product name
- Kaempferol-3-O-rhamnoside
- Packaging
- 5mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- orb594646
- Product name
- Kaempferol-3-O-glucorhamnoside
- Packaging
- 20mg
- Price
- $513.4
- Updated
- 2021/12/16
Afzelin Chemical Properties,Usage,Production
Description
Afzelin (Synonyms: Kaempferol-3-O-rhamnoside) is a flavonoid isolated from Thesium chinense Turcz. and widely distributed in Korea and China. It has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis Induced cardiotoxicity and scopolamine -induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin.
Uses
Kaempferol 3-O-α-L-Rhamnoside is found in Cornus macrophylla and has shown to have antibacterial activity against Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals.
Definition
ChEBI: Afzelin is a glycosyloxyflavone that is kaempferol attached to an alpha-L-rhamnosyl residue at position 3 via a glycosidic linkage. It has a role as a plant metabolite, an antibacterial agent and an anti-inflammatory agent. It is a glycosyloxyflavone, a trihydroxyflavone and a monosaccharide derivative. It is functionally related to a kaempferol. It is a conjugate acid of an afzelin(1-).
References
[1] SO-YOUNG OH. Central administration of afzelin extracted from Ribes fasciculatum improves cognitive and memory function in a mouse model of dementia.[J]. Scientific Reports, 2021: 9182. DOI:10.1038/s41598-021-88463-6.
[2] LEI XIA. Afzelin induces immunogenic cell death against lung cancer by targeting NQO2.[J]. BMC Complementary Medicine and Therapies, 2023, 23 1: 381. DOI:10.1186/s12906-023-04221-3.
[3] EVA RACHMI. Identification of afzelin potential targets in inhibiting triple-negative breast cancer cell migration using reverse docking.[J]. Porto biomedical journal, 2020, 5 6: e095. DOI:10.1097/j.pbj.0000000000000095.
[4] SIMPLICE JOEL NDENDOUNG TATSIMO. Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum.[J]. BMC Research Notes, 2012, 5: 158. DOI:10.1186/1756-0500-5-158.
[5] YOUNG-KYOON KIM. Isolation of flavonol rhamnosides fromloranthus tanakae and cytotoxic effect of them on human tumor cell lines[J]. Archives of Pharmacal Research, 2004, 27 1: 44-47. DOI:10.1007/BF02980044.
[6] VINIT RAJ. Antiviral activities of 4H-chromen-4-one scaffold-containing flavonoids against SARS–CoV–2 using computational and in vitro approaches[J]. Journal of Molecular Liquids, 2022, 353: Article 118775. DOI:10.1016/j.molliq.2022.118775.
[7] BORBáLA VERMES . The synthesis of afzelin, paeonoside and kaempferol 3-O-β-rutinoside[J]. Phytochemistry, 1976, 15 8: Pages 1320-1321. DOI:10.1016/0031-9422(76)85106-0.
Afzelin Preparation Products And Raw materials
Raw materials
Preparation Products
Afzelin Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@seqchem.com
- Country
- United Kingdom
- ProdList
- 3113
- Advantage
- 69
- Tel
- --
- Fax
- --
- info@apinchemicals.com
- Country
- United Kingdom
- ProdList
- 6807
- Advantage
- 42
View Lastest Price from Afzelin manufacturers
- Product
- Afzelin 482-39-3
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-01-02
- Product
- KAEMPFEROL 3-O-GLUCORHAMNOSIDE 482-39-3
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-18