GRANISETRON-D3

Product Name: GRANISETRON-D3
CAS No.: 34252-44-3
Chemical Name: GRANISETRON-D3
Synonyms: Granisetron ImpurityCl;Granisetron EP impurity G;3-Carboxy-2-methyl-2H-indazole;2-Methylindazole-3-carboxylicAci;2-Methylindazole-3-carboxylic acid;2-Methyl-2H-indazole-3-carboxylic A;Granisetron Hydrochloride Impurity G;2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID;2H-Indazole-3-carboxylic acid,2-methyl-;Granisetron Hydrochloride EP Impurity G
CBNumber: CB6324078
Molecular Formula: C9H8N2O2
Formula Weight: 176.17
MOL File: 34252-44-3.mol

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GRANISETRON-D3 Property

Melting point:: 217-219
Boiling point:: 417.4±18.0 °C(Predicted)
Density: 1.35
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.02±0.10(Predicted)
color: White to Off-White

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Safety

Hazard Codes: Xn
Risk Statements: 22-36-36/37/38-20/21/22
Safety Statements: 26-36/37/39-22
RIDADR: 2811
Hazard Note: Harmful
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M313460
Product name: 2-Methylindazole-3-carboxylicAcid
Packaging: 100mg
Price: $175
Updated: 2021/12/16

TRC

Product number: M313460
Product name: 2-Methylindazole-3-carboxylicAcid
Packaging: 250mg
Price: $460
Updated: 2021/12/16

TRC

Product number: M313460
Product name: 2-Methylindazole-3-carboxylicAcid
Packaging: 1g
Price: $1275
Updated: 2021/12/16

Matrix Scientific

Product number: 126173
Product name: 2-Methyl-2H-indazole-3-carboxylicacid
Purity: >95%
Packaging: 5g
Price: $630
Updated: 2021/12/16

AK Scientific

Product number: Y5387
Product name: 2-Methyl-2H-indazole-3-carboxylicacid
Packaging: 25g
Price: $659
Updated: 2021/12/16

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GRANISETRON-D3 Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

2-Methyl-2H-indazole-3-carboxylic acid can be used as a reagent used to synthesize 5-HT2A and 5-HT3 receptor ligands for use in treating CNS-related disorders.

Synthesis

109216-61-7

34252-44-3

(Step 1) Synthesis of 2-methyl-2H-indazole-3-carboxylic acid: 2-methyl-2H-indazole-3-carboxylic acid methyl ester (1.59 g, 8.36 mmol) was dissolved in tetrahydrofuran (85 mL), followed by addition of 0.25 N sodium hydroxide solution (50 mL, 12.5 mmol). The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Water (appropriate amount) was added to the residue, which was then acidified with 1 N hydrochloric acid (50 mL). The precipitate precipitated was collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give 2-methyl-2H-indazole-3-carboxylic acid (1.34 g, 91% yield) as a colorless solid.1H-NMR (DMSO-d6) δ: 4.43 (s, 3H), 7.29 (m, 1H), 7.35 (m, 1H), 7.74 (dd, J = 8.1, 1.0 Hz, 1H), 7.98 (d, J = 8.5 Hz, 1H), 13.59 (broad s, 1H).MS (ESI) m/z 177 (M++1).

References

[1] Journal of Medicinal Chemistry, 1987, vol. 30, # 9, p. 1535 - 1537
[2] Patent: EP1346982, 2003, A1
[3] Letters in Organic Chemistry, 2011, vol. 8, # 10, p. 722 - 727
[4] Patent: WO2008/61688, 2008, A1. Location in patent: Page/Page column 21

GRANISETRON-D3 Preparation Products And Raw materials

Raw materials

Tetrahydrofuran Indazole Iodomethane n-Butyllithium

Preparation Products

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GRANISETRON-D3 Suppliers

Belgium 1 Canada 1 China 107 Germany 1 India 6 United Kingdom 1 United States 10 Global 127

J & K SCIENTIFIC LTD.

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Thermo Fisher Scientific

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Shanghai T&W Pharmaceutical Co., Ltd.

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View Lastest Price from GRANISETRON-D3 manufacturers

Career Henan Chemical Co

Product: 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID 34252-44-3
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-02-04

34252-44-3, GRANISETRON-D3Related Search:

N-METHYL-(1H)INDAZOLE-3-CARBOXYLIC ACID,1-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID Granisetron Hydrochloride Granisetron Impurity F 1-Methyl-1H-indazole-3-carboxylic Acid Anhydride N-[(1R,3r,5S)-9-azabicyclo[3.3.1]non-3-yl]-1-Methyl-1H-indazole-3-carboxaMide hydrochloride exo-Granisetron (Granisetron Impurity F) Granisetron nitrogen oxide Endo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane GRANISETRON IMPURITY B Indazole-3-carboxylic acid 5-FLUORO-1-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID 5-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID ethyl 6-(trifluoromethyl)-1H-indazole-3-carboxylate Lonidamine 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID 2-METHYL-2H-INDAZOLE-3-CARBALDEHYDE (2-METHYL-2H-INDAZOL-3-YL)METHANOL ETHYL 2-METHYL-2H-INDAZOL-3-YL CARBOXYLATE

Granisetron Impurity 7（Granisetron EP Impurity G）

2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID

2-Methylindazole-3-carboxylic acid

2H-Indazole-3-carboxylic acid,2-methyl-

Granisetron EP impurity G

3-Carboxy-2-methyl-2H-indazole

2-Methylindazole-3-carboxylic acid 2-Methyl-2H-indazole-3-carboxylic acid

2-Methyl-2H-indazole-3-carboxylicacid97%

2-Methylindazole-3-carboxylic acid 2-Methyl-2H-indazole

2-Methyl-2H-indazole-3-carboxylic A

2-Methylindazole-3-carboxylicAci

1-methyl-N-[(1R,3s,5S)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide (exo-granisetron)

Granisetron Hydrochloride Impurity G

Granisetron Hydrochloride EP Impurity G

Granisetron ImpurityCl

34252-44-3

Chemical Amines

Amines

Aromatics

Heterocycles