1-Methylindazole-3-carboxylic acid
- Product Name
- 1-Methylindazole-3-carboxylic acid
- CAS No.
- 50890-83-0
- Chemical Name
- 1-Methylindazole-3-carboxylic acid
- Synonyms
- 1-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID;Granisetron Related CoMpound D;AKOS BB-9979;3-Dicyclohexylurea;TIMTEC-BB SBB000193;N'-Dicyclohexylurea;N-methylindazolic acid;Granisetron Impurity D;1-Methyl-indazole-3-acid;Granisetron EP impurity D
- CBNumber
- CB2730011
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 50890-83-0.mol
1-Methylindazole-3-carboxylic acid Property
- Melting point:
- 213 °C
- Boiling point:
- 383.7±15.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.14±0.10(Predicted)
- form
- Solid
- color
- White to Off White
- Water Solubility
- Insoluble in water. Soluble in DMSO and Methanol.
- InChI
- InChI=1S/C9H8N2O2/c1-11-7-5-3-2-4-6(7)8(10-11)9(12)13/h2-5H,1H3,(H,12,13)
- InChIKey
- OVVDFORZEGKEJM-UHFFFAOYSA-N
- SMILES
- N1(C)C2=C(C=CC=C2)C(C(O)=O)=N1
- CAS DataBase Reference
- 50890-83-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36-36/37/38
- Safety Statements
- 26-36/37/39-22
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHR2871
- Product name
- Granisetron Related Compound D
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 50MG
- Price
- $576
- Updated
- 2024/03/01
- Product number
- 1298140
- Product name
- Granisetron Related Compound D
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 15mg
- Price
- $1500
- Updated
- 2024/03/01
- Product number
- M2143
- Product name
- 1-Methylindazole-3-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $116
- Updated
- 2023/06/20
- Product number
- M2143
- Product name
- 1-Methylindazole-3-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $278
- Updated
- 2024/03/01
- Product number
- H26879
- Product name
- 1-Methylindazole-3-carboxylic acid, 97%
- Packaging
- 1g
- Price
- $32.65
- Updated
- 2024/03/01
1-Methylindazole-3-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
Off White Solid
Uses
1-Methylindazole-3-carboxylic acid is used as important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. It is also used as a pharmaceutical adjuvant, Granisetron Impurity D.
Uses
Granisetron Impurity D.
Synthesis Reference(s)
The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o
Synthesis
Calcium oxide (7.0 g, 0.124 mol, 2.0 molar equiv.) was added to technical methanol (150 ml), and the mixture was heated under reflux for 2 hours in a nitrogen atmosphere Indazole-3-carboxylic acid (10 g, 0.062 mol) was then added, and the reflux was continued for 2 hours. Dimethyl sulfate (15.6 g, 11.8 ml, 0.124 mole, 2.0 molar equiv.) was added dropwise under reflux for 2 hours, and the reflux continued for 2 hours. Water (100 ml) and 46% aqueous sodium hydroxide solution were added to produce a pH of about 14. Then, conc. hydrochloric acid was added to the reaction mixture to produce a pH of about 4. Calcium sulfate was collected by filtration and washed on a filter with hot methanol (3×30 ml). The methanol was removed under reduced pressure from the filtrate. The residuary mixture was stirred vigorously for 6 hours with a controlled pH of about 4. The solid product was collected by filtration, washed with water (3×30 ml), and dried in an oven at 50° C. overnight to give crude 1-Methylindazole-3-carboxylic acid.
Purification Methods
The crude 1-Methylindazole-3-carboxylic acid (1-MICA) (10.4 g) was treated by slurry in a methanol-water (3:7) mixture heated under reflux for 4 hours. The suspension was cooled to room temperature, and the solid product was collected by filtration, washed with the methanol-water (3:7) mixture (3×10 ml), and dried in an oven at 50° C. overnight to give pure 1-MICA (9.3 g, 85.6% yield, purity by HPLC: 99.70%).
1-Methylindazole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Methylindazole-3-carboxylic acid manufacturers
- Product
- 1-Methylindazole-3-carboxylic acid 50890-83-0
- Price
- US $60.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/week
- Release date
- 2024-05-23
- Product
- 1-Methylindazole-3-carboxylic acid 50890-83-0
- Price
- US $2380.00/KG
- Min. Order
- 1KG
- Purity
- assay 97---102.0%
- Supply Ability
- 50KG
- Release date
- 2021-06-05
- Product
- 1-Methylindazole-3-carboxylic acid 50890-83-0
- Price
- US $25.00/ASSAYS
- Min. Order
- 100ASSAYS
- Purity
- 99.5%
- Supply Ability
- 100 mt
- Release date
- 2024-11-18