5-Fluoroorotic acid
- Product Name
- 5-Fluoroorotic acid
- CAS No.
- 703-95-7
- Chemical Name
- 5-Fluoroorotic acid
- Synonyms
- foa;fo;5-FOA;5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyriMidine-4-carboxylic acid;5' FOA;ro2-9945;nsc31712;Fluoxydin;ent-26398;WR 152520
- CBNumber
- CB6325772
- Molecular Formula
- C5H3FN2O4
- Formula Weight
- 174.09
- MOL File
- 703-95-7.mol
5-Fluoroorotic acid Property
- Melting point:
- 278 °C (dec.)(lit.)
- Boiling point:
- 143°C (rough estimate)
- Density
- 1.6154 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- NH4OH 4 M: 50 mg/mL, clear, faintly yellow
- pka
- 2.04±0.20(Predicted)
- form
- solid
- color
- Pale yellow
- Merck
- 14,4176
- InChIKey
- LODRRYMGPWQCTR-UHFFFAOYSA-N
- CAS DataBase Reference
- 703-95-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36-36/37/39-27
- WGK Germany
- 3
- RTECS
- UV7800000
- F
- 10
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F0382
- Product name
- 5-Fluoroorotic Acid Monohydrate
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- F0382
- Product name
- 5-Fluoroorotic Acid Monohydrate
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 100mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- PC408010
- Product name
- 5-Fluorooroticacid
- Packaging
- 1g
- Price
- $42
- Updated
- 2021/12/16
- Product number
- 4H53-3-25
- Product name
- 5-Fluoroorotic acid
- Purity
- 99%
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- PC408010
- Product name
- 5-Fluorooroticacid
- Packaging
- 5g
- Price
- $77
- Updated
- 2021/12/16
5-Fluoroorotic acid Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Crystalline Solid
Uses
Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.
Uses
5-FOA(5-Fluoroorotic acid ) has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.
5-Fluoroorotic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Fluoroorotic acid Suppliers
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View Lastest Price from 5-Fluoroorotic acid manufacturers
- Product
- 5-Fluoroorotic acid 703-95-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-18
- Product
- 5-Fluoroorotic Acid 703-95-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10 ton
- Release date
- 2024-08-21
- Product
- 5-Fluoroorotic acid 703-95-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10