Triethylene glycol dimethyl ether Property

Melting point:

−45 °C(lit.)

Boiling point:

216 °C(lit.)

Density 

0.986 g/mL at 25 °C(lit.)

vapor density 

>4.7 (vs air)

vapor pressure 

1.2 hPa (20 °C)

refractive index 

n20/D 1.423(lit.)

Flash point:

231 °F

storage temp. 

Store below +30°C.

solubility 

>1000g/l soluble

form 

Liquid

color 

APHA: ≤20

explosive limit

0.7%(V)

Water Solubility 

Soluble

Sensitive 

Hygroscopic

Merck 

14,9692

BRN 

1700630

Dielectric constant

7.5

InChIKey

YFNKIDBQEZZDLK-UHFFFAOYSA-N

LogP

-0.52 at 20℃

CAS DataBase Reference

112-49-2(CAS DataBase Reference)

NIST Chemistry Reference

2,5,8,11-Tetraoxadodecane(112-49-2)

EPA Substance Registry System

Triethylene glycol dimethyl ether (112-49-2)

Safety

Hazard Codes 

T

Risk Statements 

61-19-62

Safety Statements 

53-45

WGK Germany 

1

RTECS 

XF0665000

F 

3

Autoignition Temperature

375 °F

TSCA 

Yes

HS Code 

29094990

Toxicity

LD50 orally in Rabbit: 5390 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Triethylene glycol dimethyl ether Chemical Properties,Usage,Production

Chemical Properties

Water-white liquid; mild ether odor. D 0.9862 (20/20C), refr index 1.4233 (20C), flash p 232F (111C), bp 216.0C (760mmHg), 153.6C (100 mm Hg), fp ?46C. Completely soluble in water and hydrocarbons at 20C. May contain peroxides. Combustible.

Uses

Triethylene glycol dimethyl ether is used as a solvent for gases and coupling immiscible liquid. It is also used to prepare perfluoro-triethyleneglycoldimethylether.

Uses

Triethylene glycol dimethyl ether may be used as an analytical standard for the quantification of the analyte in water samples using in vitro bioassays and chemical screening technique.

Uses

Labelled Triglyme. It is used as a solvent.

Definition

ChEBI: A polyether that consists of dodecane in which the carbon atoms at positions 2, 5, 8 and 11 are replaced by oxygen atoms.

Application

Triethylene glycol dimethyl ether is a member of the glycol ether class of industrial solvents. These solvents are widely used to manufacture protective coatings such as lacquers, metal coatings, baking enamels, phenolic varnishes, epoxy resin coatings, and alkyl resins[1].

Reactivity Profile

TRIETHYLENE GLYCOL DIMETHYL ETHER forms explosive peroxides on prolonged exposure to air. Its decomposition products may be sensitive to shock. The bulk chemical is stable for 2 weeks at temperatures up to 140° F when protected from light. TRIETHYLENE GLYCOL DIMETHYL ETHER is incompatible with strong oxidizers. TRIETHYLENE GLYCOL DIMETHYL ETHER is also incompatible with strong acids. TRIETHYLENE GLYCOL DIMETHYL ETHER may react with peroxides, oxygen, nitric acid and sulfuric acid. .

Flammability and Explosibility

Non flammable

Toxicology

Triethylene glycol dimethyl ether (triEGdiME) is a widely used organic solvent. It is structurally related to several compounds that produce reproductive and developmental toxicity, including teratogenicity in laboratory animals. In the present studies, triEGdiME (0, 75, 125, 175, or 250 mg/kg/day) is administered by gavage in distilled water to timed-pregnant New Zealand white rabbits (15-25 dams/group) during major organogenesis [Gestational Days (gd) 6-19]. In the triEGdiME study, clinical signs of toxicity were minimal, and there was no increased maternal mortality. Maternal body weight and gravid uterine weight were significantly reduced at 250 mg/kg/day, whereas maternal weight gain during treatment was significant. They were depressed at doses of 175 mg/kg/day and above. Prenatal mortality was significantly increased at 250 mg triEGdiME/kg/day. TriEGdiME at doses of 175 and 250 mg/kg/day caused a significant increase in the incidence of malformed fetuses per litter. Malformations noted most frequently in fetuses of normal size included anonychia (missing toenails with no digital abnormalities), abnormally small spleen, and hydronephrosis[1].

Purification Methods

Reflux it with, and distil it from sodium hydride or LiAlH4. [Beilstein 1 IV 2401.]