Trimethylsilyl 2-(fluorosulfonyl)difluoroacetate
- Product Name
- Trimethylsilyl 2-(fluorosulfonyl)difluoroacetate
- CAS No.
- 120801-75-4
- Chemical Name
- Trimethylsilyl 2-(fluorosulfonyl)difluoroacetate
- Synonyms
- TFDA;TRIMETHYLSILYL 2,2-DIFLUORO-2-(FLUOROSULFONYL)ACETATE;TRIMETHYLSILYL FLUOROSULFONYLDIFLUOROACETATE;trimethylsilyl-2,2-difluoro-2-(fluorosulphonyl)acetate;TRIMETHYLSILYL 2,2-DIFLUORO-2-(FLUOROSUL;TriMethylsilyl Difluoro(fluorosulfonyl)acetate;TRIMETHYLSILYL 2-(FLUOROSULFONYL)DIFLUOROACETATE;TRIMETHYLSILYL 2-(FLUOROSULPHONYL)DIFLUOROACETATE;Trimethylsilyl2-(fluorosulphonyl)difluoroacetate97%;Trimethylsilyl 2-(fluorosulphonyl)difluoroacetate 97%
- CBNumber
- CB6328324
- Molecular Formula
- C5H9F3O4SSi
- Formula Weight
- 250.27
- MOL File
- 120801-75-4.mol
Trimethylsilyl 2-(fluorosulfonyl)difluoroacetate Property
- Boiling point:
- 156 °C (lit.)
- Density
- 1.27 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.367(lit.)
- Flash point:
- 80 °F
- storage temp.
- 2-8°C, stored under nitrogen, away from moisture
- solubility
- Soluble in ether, toluene, and diglyme.
- form
- clear liquid
- color
- Colorless to Almost colorless
- Specific Gravity
- 1.28
- Water Solubility
- Reacts with water.
- Hydrolytic Sensitivity
- 7: reacts slowly with moisture/water
- InChI
- InChI=1S/C5H9F3O4SSi/c1-14(2,3)12-4(9)5(6,7)13(8,10)11/h1-3H3
- InChIKey
- XHVSCKNABCCCAC-UHFFFAOYSA-N
- SMILES
- C(O[Si](C)(C)C)(=O)C(F)(F)S(F)(=O)=O
- CAS DataBase Reference
- 120801-75-4(CAS DataBase Reference)
- EPA Substance Registry System
- Acetic acid, 2,2-difluoro-2-(fluorosulfonyl)-, trimethylsilyl ester (120801-75-4)
Safety
- Hazard Codes
- C,F,Xi
- Risk Statements
- 10-34
- Safety Statements
- 16-26-27-36/37/39-45
- RIDADR
- UN 2920 8/PG 2
- WGK Germany
- 2
- Hazard Note
- Flammable/Corrosive
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 531421
- Product name
- Trimethylsilyl 2,2-difluoro-2-(fluorosulfonyl)acetate
- Packaging
- 25g
- Price
- $209
- Updated
- 2025/07/31
- Product number
- T3022
- Product name
- Trimethylsilyl Difluoro(fluorosulfonyl)acetate
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $150
- Updated
- 2025/07/31
- Product number
- T3022
- Product name
- Trimethylsilyl Difluoro(fluorosulfonyl)acetate
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $591
- Updated
- 2025/07/31
- Product number
- T798170
- Product name
- Trimethylsilyl 2,2-difluoro-2-(fluorosulfonyl)acetate
- Packaging
- 50g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- 006192
- Product name
- Trimethylsilyl 2-(fluorosulfonyl)difluoroacetate
- Purity
- 90%
- Packaging
- 100g
- Price
- $440
- Updated
- 2021/12/16
Trimethylsilyl 2-(fluorosulfonyl)difluoroacetate Chemical Properties,Usage,Production
Physical properties
73–74 °C at 35mm Hg.
Uses
Fluoroalkylation agent. Reactant for Preparation of difluorocyclopropenes and Preparation of difluorocarbene reagents.
Uses
- Fluoroalkylation agent
Reactant for:
- Preparation of difluorocyclopropenes
- Preparation of difluorocarbene reagents
Uses
Trimethylsilyl Fluorosulfonyldifluoroacetate is a reagent used in Synthesis of gem-Difluorocyclopropanes, Synthesis of gem-Difluorocyclopropenes, etc.
Preparation
Prepared by treatment of FO2SCF2CO2H with (CH3)3SiCl.
reaction suitability
reaction type: C-C Bond Formation
Synthesis
107-46-0
677-67-8
420-56-4
120801-75-4
In this embodiment, trimethylsilyl chloride was included in the initial feed to the reactor to reduce the RSUA content in the product RSUTMS. Hexamethyldisiloxane (28.3 g, 0.174 mol) and trimethylchlorosilane (CTMS, 2.8 g, 0.0258 mol) were added to the C oscillation tube. After sealing the reaction tube, it was cooled in dry ice, evacuated and subsequently RSU (33 g, 0.183 mol) was added. The reaction tube was heated at 105°C for 6 hours to a maximum pressure of 67 psig (0.56 MPa) during the reaction. Upon completion of the reaction, the mixture was cooled to room temperature and the yellow-brown liquid product was transferred to a distillation flask. Analysis of the crude product by 1H NMR showed a conversion of about 93% based on the limiting reactant hexamethyldisiloxane.19F NMR analysis of the reaction mixture indicated that the concentration of RSUA relative to RSUTMS was about 8.6 mol%. The low-boiling components (RSU and fluorotrimethylsilane) were first removed by distillation at atmospheric pressure until the tank temperature reached 103 °C. The reaction was carried out at a pressure of 0.5 mmHg (4 mmHg). Subsequent distillation of RSUTMS at a pressure of 34 mmHg (4.5 kPa) yielded 34.6 g (0.138 mol) of product containing about 2 mole % of RSUA. the distillation product had a yield of 84% over a 6 hour reaction time. The lower RSUA content compared to Example 1 without added CTMS demonstrates the effectiveness of adding trimethylmethylsilyl chloride at the beginning of the reaction.
References
[1] Patent: US2007/270602, 2007, A1. Location in patent: Page/Page column 4
Trimethylsilyl 2-(fluorosulfonyl)difluoroacetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Trimethylsilyl 2-(fluorosulfonyl)difluoroacetate manufacturers
- Product
- Trimethylsilyl 2-(fluorosulfonyl)difluoroacetate 120801-75-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09
- Product
- Trimethylsilyl 2-(fluorosulfonyl)difluoroacetate 120801-75-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98-100%
- Supply Ability
- 1000kg
- Release date
- 2018-08-20