Bisindolylmaleimide V
- Product Name
- Bisindolylmaleimide V
- CAS No.
- 113963-68-1
- Chemical Name
- Bisindolylmaleimide V
- Synonyms
- RO 31-6045;BISINDOLYLMALEIMIDE V;Sotrastaurin Impurity 12;n-methylbis(indol-3-yl)maleimide;BisindolylMaleiMide V [Ro 31-6045];1-METHYL-3,4-BIS(3-INDOLYL)MALEIMIDE;1-METHYL-3,4-BIS(INDOL-3-YL)MALEIMIDE;2,3-Di(1H-Indol-3-yl)-N-methylmaleimide;2,3-BIS(1H-INDOL-3-YL)-N-METHYLMALEIMIDE;3,4-Di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione
- CBNumber
- CB6329851
- Molecular Formula
- C21H15N3O2
- Formula Weight
- 341.36
- MOL File
- 113963-68-1.mol
Bisindolylmaleimide V Property
- Melting point:
- >260 °C
- Boiling point:
- 655.7±55.0 °C(Predicted)
- Density
- 1.450±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: soluble
- form
- solid
- pka
- 15.89±0.30(Predicted)
- color
- Orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- CAS DataBase Reference
- 113963-68-1(CAS DataBase Reference)
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 203303
- Product name
- Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem
- Purity
- A cell-permeable negative control compound for protein kinase C inhibition studies (IC?? >100 μM).
- Packaging
- 400μG
- Price
- $68.9
- Updated
- 2023/01/07
- Product number
- 203303
- Product name
- Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem
- Packaging
- 1mg
- Price
- $223
- Updated
- 2023/01/07
- Product number
- B6143
- Product name
- Bisindolylmaleimide V
- Packaging
- 10MG
- Price
- $127
- Updated
- 2025/07/31
- Product number
- B6143
- Product name
- Bisindolylmaleimide V
- Packaging
- 50MG
- Price
- $383
- Updated
- 2025/07/31
- Product number
- 13300
- Product name
- Bisindolylmaleimide V
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $64
- Updated
- 2024/03/01
Bisindolylmaleimide V Chemical Properties,Usage,Production
Description
Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1?Does not inhibit PKC (at concentrations <100?mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2?such as GF 109203X3?and other structurally related inhibitors4.
Uses
Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 μM[1]. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 μM[2].
Definition
ChEBI: Ro 31-6045 is a member of indoles.
References
[1] NELLY MARMY-CONUS Richard B P Katherine M Hannan. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70s6k/p85s6k: implications for the analysis of S6K signalling[J]. FEBS Letters, 2002, 519 1-3: 135-140. DOI:10.1016/s0014-5793(02)02738-2
[2] C S HARMON. Bisindolylmaleimide protein-kinase-C inhibitors delay the decline in DNA synthesis in mouse hair follicle organ cultures.[J]. Skin pharmacology : the official journal of the Skin Pharmacology Society, 1997, 10 2: 71-78. DOI:10.1159/000211471
[3] D. TOULLEC. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.[J]. The Journal of Biological Chemistry, 1991, 12 1: 15771-15781. DOI:10.1016/s0021-9258(18)98476-0
[4] PETER D. DAVIS. Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides[J]. Journal of Medicinal Chemistry, 1992, 35 1: 177-184. DOI:10.1021/jm00079a024
Bisindolylmaleimide V Preparation Products And Raw materials
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