Bisindolylmaleimide V
- Product Name
- Bisindolylmaleimide V
- CAS No.
- 113963-68-1
- Chemical Name
- Bisindolylmaleimide V
- Synonyms
- RO 31-6045;BISINDOLYLMALEIMIDE V;Sotrastaurin Impurity 12;n-methylbis(indol-3-yl)maleimide;BisindolylMaleiMide V [Ro 31-6045];1-METHYL-3,4-BIS(3-INDOLYL)MALEIMIDE;1-METHYL-3,4-BIS(INDOL-3-YL)MALEIMIDE;2,3-Di(1H-Indol-3-yl)-N-methylmaleimide;2,3-BIS(1H-INDOL-3-YL)-N-METHYLMALEIMIDE;3,4-Di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione
- CBNumber
- CB6329851
- Molecular Formula
- C21H15N3O2
- Formula Weight
- 341.36
- MOL File
- 113963-68-1.mol
Bisindolylmaleimide V Property
- Melting point:
- >260 °C
- Boiling point:
- 655.7±55.0 °C(Predicted)
- Density
- 1.450±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: soluble
- form
- solid
- pka
- 15.89±0.30(Predicted)
- color
- Orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- CAS DataBase Reference
- 113963-68-1(CAS DataBase Reference)
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 203303
- Product name
- Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem
- Purity
- A cell-permeable negative control compound for protein kinase C inhibition studies (IC?? >100 μM).
- Packaging
- 400μG
- Price
- $68.9
- Updated
- 2023/01/07
- Product number
- 203303
- Product name
- Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem
- Packaging
- 1mg
- Price
- $223
- Updated
- 2023/01/07
- Product number
- 13300
- Product name
- Bisindolylmaleimide V
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $64
- Updated
- 2024/03/01
- Product number
- 13300
- Product name
- Bisindolylmaleimide V
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $280
- Updated
- 2024/03/01
- Product number
- 13300
- Product name
- Bisindolylmaleimide V
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $497
- Updated
- 2024/03/01
Bisindolylmaleimide V Chemical Properties,Usage,Production
Description
Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1?Does not inhibit PKC (at concentrations <100?mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2?such as GF 109203X3?and other structurally related inhibitors4.
Definition
ChEBI: Ro 31-6045 is a member of indoles.
References
1) Marmy-Conus?et al.?(2002),?Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling; FEBS Lett.,?519?135 2) Harmon?et al.?(1997),?Bisindolylmaleimide protein-kinase C inhibitors delay in the decline in DNA synthesis in mouse hair follicle organ cultures; Skin Pharmacol.,?10?71 3) Toullec?et al.?(1991),?The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C; J. Biol. Chem.,?266?15771 4) Davis?et al. (1992),?Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides; J. Med. Chem.,?35?177