GSK-626616

Product Name: GSK-626616
CAS No.: 1025821-33-3
Chemical Name: GSK-626616
Synonyms: GSK-626616;(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone;(Z)-2-((2,6-Dichlorophenyl)amino)-5-(quinoxalin-6-ylmethylene)thiazol-4(5H)-one;4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-;GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase
CBNumber: CB63303333
Molecular Formula: C18H10Cl2N4OS
Formula Weight: 401.27
MOL File: 1025821-33-3.mol

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GSK-626616 Property

Melting point:: 281 - 282oC
Boiling point:: 574.8±60.0 °C(Predicted)
Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: Refrigerator, under inert atmosphere
solubility: Chloroform (Slightly, Heated), Methanol (Slightly)
pka: -0.94±0.20(Predicted)
form: Solid
color: Pale Yellow to Light Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3355
Product name: GSK626616
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $87
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3355
Product name: GSK626616
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $350
Updated: 2024/03/01

Tocris

Product number: 6638
Product name: GSK626616
Purity: ≥98%(HPLC)
Packaging: 50
Price: $861
Updated: 2021/12/16

Tocris

Product number: 6638
Product name: GSK626616
Purity: ≥98%(HPLC)
Packaging: 10
Price: $205
Updated: 2021/12/16

TRC

Product number: G797853
Product name: GSK-626616
Packaging: 10mg
Price: $160
Updated: 2021/12/16

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GSK-626616 Chemical Properties,Usage,Production

Uses

GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.

storage

Store at +4°C

GSK-626616 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-626616 Suppliers

China 28 United Kingdom 1 United States 6 Global 35

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(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone

GSK-626616

4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-

GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase

(Z)-2-((2,6-Dichlorophenyl)amino)-5-(quinoxalin-6-ylmethylene)thiazol-4(5H)-one

1025821-33-3