1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID

Product Name: 1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID
CAS No.: 139755-99-0
Chemical Name: 1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID
Synonyms: TIMTEC-BB SBB010494;CHEMBRDG-BB 4402460;Sildenafil Impurity 57;ASINEX-REAG BAS 02107705;Methisosildenafil Impurity 14;2-methyl-5-propyl-3-pyrazolecarboxylate;1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID;2-methyl-5-propylpyrazole-3-carboxylic acid;1-METHYL-3-PROPYL-5-PYRAZOLE CARBOXYLIC ACID;1-Methyl-3-propyl-1H-pyrazole-5-carboxylicaci
CBNumber: CB6337087
Molecular Formula: C8H12N2O2
Formula Weight: 168.19
MOL File: 139755-99-0.mol

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1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID Property

Melting point:: 150-154 °C
Boiling point:: 330.3±30.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Sightly), Methanol (Slightly)
form: Solid
pka: 3.10±0.25(Predicted)
color: Off-White to Pale Beige
CAS DataBase Reference: 139755-99-0(CAS DataBase Reference)

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Safety

Risk Statements: 20/21/22
Safety Statements: 3/9-24/25-36/37
HazardClass: IRRITANT
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H290May be corrosive to metals

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P331Do NOT induce vomiting.

P363Wash contaminated clothing before reuse.

P390Absorb spillage to prevent material damage.

P402Store in a dry place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

TRC

Product number: M320655
Product name: 1-Methyl-3-propyl-1H-pyrazole-5-carboxylicAcid
Packaging: 1g
Price: $325
Updated: 2021/12/16

TRC

Product number: M320655
Product name: 1-Methyl-3-propyl-1H-pyrazole-5-carboxylicAcid
Packaging: 2g
Price: $640
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0021404
Product name: 2-METHYL-5-PROPYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 500MG
Price: $739.2
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0021404
Product name: 2-METHYL-5-PROPYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5G
Price: $2044.35
Updated: 2021/12/16

Matrix Scientific

Product number: 032788
Product name: 2-Methyl-5-propyl-2H-pyrazole-3-carboxylic acid
Packaging: 1g
Price: $378
Updated: 2021/12/16

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1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Intermediate in the production of Sildenafil and respective analogs.

Synthesis

133261-07-1

139755-99-0

Preparation of Intermediate I-04a: Ethyl 1-methyl-3-n-propyl-pyrazole-5-carboxylate (11 g, 56.12 mmol) was dissolved in 6 M hydrochloric acid solution (121 mL) and heated to 100°C for overnight reaction. Upon completion of the reaction, the mixture was concentrated under vacuum and subsequently extracted with ethyl acetate (EA) and the organic layer was washed with water. Finally, the organic layer was concentrated in vacuum to afford the target product 1-methyl-3-propyl-1H-pyrazole-5-carboxylic acid (I-04a) (9.4 g, 98% yield).ESI-MS (M + 1): 169; calculated value C8H12N2O2: 168.1.

References

[1] Patent: WO2014/131855, 2014, A1. Location in patent: Page/Page column 80
[2] Patent: WO2016/20307, 2016, A1. Location in patent: Page/Page column 50
[3] Patent: US2008/194529, 2008, A1. Location in patent: Page/Page column 56-57
[4] Patent: WO2015/114647, 2015, A1. Location in patent: Page/Page column 46; 47
[5] Patent: US5250534, 1993, A

1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Ethanol Diethyl oxalate Sodium Methylhydrazine 2-Pentanone

Preparation Products

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1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID Suppliers

Canada 1 China 115 Europe 1 Hungary 1 India 4 Russia 1 United Kingdom 6 United States 21 Global 150

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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Nanjing Habo Medical Technology Co., Ltd.

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Adamas Reagent, Ltd.

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Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
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View Lastest Price from 1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID 139755-99-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-22

139755-99-0, 1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACIDRelated Search:

2-Ethoxybenzoyl chloride 1-METHYL-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 1-Piperazinesulfonicacid,4-methyl-(9CI) 2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]BENZOIC ACID 5-CHLOROSULFONYL-2-ETHOXYBENZOIC ACID KF31327 5-chloro-2-ethoxybenzoic acid Sildenafil Impurity F Sulfosalicylic acid Sildenafil Chlorosulfonyl 4-(2-Ethoxy benzamido)-1-methyl-3-n-propyl pyrazole-5-carboxamide. 5-chloro-2-ethoxybenzoyl chloride Propoxyphenyl ThiohoMosidenafil 1-Methyl-4-nitro-3-propyl-(1H)-pyrazole-5-carboxamide 5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO[4,3-D]-7-PYRIMIDINONE 5-DIMETHOXYMETHYL-BENZO[1,3]DIOXOLE 1H-Pyrazolo[4,3-d]pyriMidine, 3-(2-Methylpropyl)- N-Des[2-(1-methyl-2-pyrrolidinyl)ethyl] Udenafil

TIMTEC-BB SBB010494

ASINEX-REAG BAS 02107705

CHEMBRDG-BB 4402460

2-METHYL-5-PROPYL-2H-PYRAZOLE-3-CARBOXYLIC ACID

1-METHYL-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID

1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID

1-METHYL-3-PROPYL-5-PYRAZOLE CARBOXYLIC ACID

2-Methyl-5-propyl-2H-pyrazole-3-carboxboxylic acid

1H-Pyrazole-5-carboxylicacid,1-methyl-3-propyl-(9CI)

2-methyl-5-propyl-3-pyrazolecarboxylate

1-methyl-3-propyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE)

1-Methyl-3-propylpyrazole-5-carboxylic acid ,98%

Methisosildenafil Impurity 14

1H-Pyrazole-5-carboxylic acid, 1-methyl-3-propyl-

Sildenafil Impurity 57

1-Methyl-3-propyl-1H-pyrazole-5-carboxylicaci

2-methyl-5-propylpyrazole-3-carboxylic acid

139755-99-0

139756-99-0

139775-99-0

C8H12N2O2

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

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