(-)-3,4-Dihydroxynorephedrine Property

Melting point:

212-215°C dec.

alpha 

D25 -31.0° (c = 0.5 in 0.01N HCl)

Boiling point:

431.6±40.0 °C(Predicted)

Density 

1.328±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

DMSO: soluble5mg/mL, clear (warmed)

pka

9.59±0.10(Predicted)

form 

powder

color 

white to light brown

Merck 

13,6725

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

RIDADR 

UN 2811 6.1 / PGII

WGK Germany 

3

HS Code 

2922504500

Toxicity

LD50 in mice (mg/kg): 12.6 i.v. (Luduena)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

(-)-3,4-Dihydroxynorephedrine Chemical Properties,Usage,Production

Chemical Properties

White Powder

Uses

A vasoconstrictor which also increases the potency and duration of anesthesia produced by local anesthetics

Uses

Vasoconstrictor;Adrenergic receptor agonist

Definition

ChEBI: Alpha-methylnoradrenaline is a catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It has a role as an alpha-adrenergic agonist, a vasoconstrictor agent and a nasal decongestant.

brand name

Neo-Cobefrin (Cook-Waite).