5-BROMOSALICYLAMIDE
Application- Product Name
- 5-BROMOSALICYLAMIDE
- CAS No.
- 6329-74-4
- Chemical Name
- 5-BROMOSALICYLAMIDE
- Synonyms
- Nsc 14278;Brn 3530373;Einecs 228-704-5;bromo-salicylamid;BROMOSALICYLAMIDE;5-BROMOSALICYLAMIDE;Salicylamide, bromo-;bromo-2-hydroxybenzamide;5-BROMO-2-HYDROXYBENZAMIDE;5-broMo-2-hydeoxybenzaMide
- CBNumber
- CB6345495
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 6329-74-4.mol
5-BROMOSALICYLAMIDE Property
- Melting point:
- 241-245 °C(lit.)
- Boiling point:
- 316.6±32.0 °C(Predicted)
- Density
- 1.759±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 7.79±0.18(Predicted)
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- 631205
- Product name
- 5-Bromosalicylamide
- Purity
- 97%
- Packaging
- 5g
- Price
- $104
- Updated
- 2023/06/20
- Product number
- 631205
- Product name
- 5-Bromosalicylamide
- Purity
- 97%
- Packaging
- 25g
- Price
- $331
- Updated
- 2023/06/20
- Product number
- B688788
- Product name
- 5-Bromosalicylamide
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB36899
- Product name
- 5-Bromosalicylamide
- Packaging
- 5G
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB36899
- Product name
- 5-Bromosalicylamide
- Packaging
- 25g
- Price
- $200
- Updated
- 2021/12/16
5-BROMOSALICYLAMIDE Chemical Properties,Usage,Production
Application
5-Bromosalicylate is an amide organic compound that can be used as a pharmaceutical synthesis intermediate.
Synthesis
89-55-4
6329-74-4
A. Procedure for the synthesis of 5-bromo-2-hydroxybenzamide: 1. In a 100 mL round-bottom flask, 5-bromosalicylic acid (30 g, 135.5 mmol) was dissolved in n-butanol (60 mL) and concentrated sulfuric acid (95.6%, 289 μL, 5.42 mmol) was added. The unit was equipped with a Dean-Stark manifold and reflux condenser and 12 mL of n-butanol was added. 2. Reflow the reaction mixture under heat for 2 days. Upon completion of the reaction, it was cooled to room temperature and concentrated to give a light yellow oil. 3. Methanol (50 mL) was added to the above oil, followed by the slow addition of a methanol solution of ammonia (7 N, 116 mL). 4. The reaction mixture was stirred at room temperature for 2 days and the progress of the reaction was monitored by HPLC. 5. 5. After completion of the reaction, the reaction mixture was concentrated to give a white solid. 6. The crude product was washed with a small amount of ethyl acetate and hexane to give 24 g of white crystalline solid in 82% yield.
References
[1] Patent: WO2005/95326, 2005, A2. Location in patent: Page/Page column 253
[2] Patent: US2018/64726, 2018, A1. Location in patent: Paragraph 0360; 0361
[3] Chemical and Pharmaceutical Bulletin, 1996, vol. 44, # 4, p. 734 - 745
[4] Patent: US2006/14737, 2006, A1. Location in patent: Page/Page column 25
5-BROMOSALICYLAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
5-BROMOSALICYLAMIDE Suppliers
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View Lastest Price from 5-BROMOSALICYLAMIDE manufacturers
- Product
- 5-BROMOSALICYLAMIDE 6329-74-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-03