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BROMOPRIDE

Product Name
BROMOPRIDE
CAS No.
4093-35-0
Chemical Name
BROMOPRIDE
Synonyms
Emoril;Viadil;Artomey;Praiden;Plesium;Opridan;Emepride;val13081;BROMOPRID;VAL 13081
CBNumber
CB8288660
Molecular Formula
C14H22BrN3O2
Formula Weight
344.25
MOL File
4093-35-0.mol
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BROMOPRIDE Property

Melting point:
148-150?C
Boiling point:
435.8±45.0 °C(Predicted)
Density 
1.4132 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
13.84±0.46(Predicted)
color 
White to Off-White
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
RTECS 
BZ3280000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29329
Product name
Bromopride
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29329
Product name
Bromopride
Packaging
25mg
Price
$456
Updated
2024/03/01
Cayman Chemical
Product number
29329
Product name
Bromopride
Packaging
5mg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
29329
Product name
Bromopride
Packaging
10mg
Price
$214
Updated
2024/03/01
TRC
Product number
B686645
Product name
Bromopride
Packaging
1mg
Price
$45
Updated
2021/12/16
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BROMOPRIDE Chemical Properties,Usage,Production

Description

Bromopride is a dopamine D2 receptor antagonist (Ki = 14 nM). It binds to bovine anterior pituitary membranes with an IC50 value of 2.13 μM. Bromopride inhibits cholinesterase activity in vitro in rat plasma and striatum homogenate (IC50s = 67.8 and 38.4 μM, respectively). It increases serum prolactin levels in rats by 100% when used at a dose of 0.02 mol/kg. Bromopride (2.5 mg/kg) decreases locomotion and rearing in an open field test and impairs acquistion, but not retention, of a conditioned avoidance response in a two-way active conditioned avoidance test in rats.

Chemical Properties

White Solid

Originator

Praiden,Italchemi,Italy,1977

Uses

An antiemetic.Bromopride is used in method and a system for analyzing neuropharmacology of a drug.

Definition

ChEBI: 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide is a member of benzamides.

Manufacturing Process

To 119 g (0.45 mol) of N-(2-diethylaminoethyl)-2-methoxy-4-aminobenzamide dissolved in 200 cc of acetic acid are added in the cold in small portions 69 g of acetic anhydride (0.45 mol + 50% excess). The starting material is made by esterifying 4-aminosalicylic acid with methanol, then acetylating with acetic anhydride and then methylating with dimethyl sulfate. The solution obtained is heated for 2 hours on a water bath and then boiled for 15 minutes. It is cooled at 25°C. While agitating constantly and maintaining the temperature between 25° and 30°C, there is added to the solution drop by drop 72 g of bromine dissolved in 60 cc of acetic acid. It is agitated for one hour. The mixture obtained is added to one liter of water and the base is precipitated by the addition of 30% soda, The precipitated base is extracted with 40 cc of methylene chloride. After evaporation of the solvent, the residue is boiled for two hours with 390 g of concentrated hydrochloric acid in 780 cc of water. It is cooled, diluted with one liter of water, 12 g of charcoal are added, and the mixture filtered. The base is precipitated with 30% soda. The N-(2- diethylaminoethyl)-2-methoxy-4-amino-5-bromobenzamide formed crystallizes, is centrifuged and washed with water. A yield of 85 g of base having a melting point of 129°-130°C is obtained.
To produce the dihydrochloride, the free base is dissolved in 110 cc of absolute alcohol, 9.6 g of dry hydrochloric acid dissolved in 35 cc of alcohol are added, followed by 2.8 cc of water. The dihydrochloride precipitates, is centrifuged, washed, and dried at 40°C. It was a solid white material having a melting point of 134°-135°C.

Therapeutic Function

Antiemetic

BROMOPRIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BROMOPRIDE Suppliers

Canada 1 China 72 Germany 1 India 6 Spain 1 Switzerland 1 United Kingdom 2 United States 16 Global 100
Shaoxing Hongda Medical Technology Co.,Ltd
Tel
18072995930
Email
sales001@hongdabova.com
Country
China
ProdList
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58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shanghai Fuhe Chemistry Technology Co., Ltd.
Tel
0086-21-67651709
Fax
0086-21-67651705
Email
cfx759@hotmail.com
Country
China
ProdList
410
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Wisdom Pharmaceutical Co., Ltd.
Tel
0086-15189180296
Fax
0086-513-81292226
Email
l_xu@wisdompharma.com
Country
China
ProdList
221
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60
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16684
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50
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
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50

4093-35-0, BROMOPRIDERelated Search:

Bromopride Hydrochloride BROMOPRIDE N-Ethyl-3-bromobenzylamine 3-Bromo-N-ethylbenzamide 3-Bromo-N-methylbenzamide 98% 5-BROMOSALICYLAMIDE Saletamide 5-BROMO-2-METHOXYBENZYLAMINE 5-BROMO-2-HYDROXYBENZYLAMINE N-(5-BROMO-2-METHOXYBENZYL)-N-METHYLAMINE 2-BROMO-5-METHOXYANILINE HCL (3-BROMOBENZYL)METHYLAMINE 5-Bromo-2-chlorobenzoic acid procainamide 5-Bromosalicylaldehyde

  • 4-Amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide,Emepride,Emoril,Viadil
  • BROMOPRID
  • 2-Methoxy-4-aMino-5-broMo-N,N-diethylaMinoethylbenzaMide
  • Opridan
  • Plesium
  • Praiden
  • 4-azanyl-5-bromo-N-(2-diethylaminoethyl)-2-methoxy-benzamide
  • 4-amino-5-bromo-n-(2-(diethylamino)ethyl)-2-methoxy-benzamid
  • 4-amino-5-bromo-n-(2-(diethylamino)ethyl)-o-anisamid
  • 4-Amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
  • Artomey
  • Benzamide, 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxy-
  • Bromoprida
  • Emepride
  • Emoril
  • n-(diethylaminoethyl)-2-methoxy-4-amino-5-bromobenzamide
  • o-Anisamide, 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-
  • VAL 13081
  • val13081
  • Valopride
  • Viadil
  • 4-AMINO-5-BROMO-N-[2-(DIETHYL-AMINO)ETHYL-O-ANISAMIDE
  • BROMOPRIDE
  • BromoprideQ: What is Bromopride Q: What is the CAS Number of Bromopride Q: What is the storage condition of Bromopride Q: What are the applications of Bromopride
  • Inhibitor,Bromopride,Dopamine Receptor,inhibit
  • Bromopride in methanol
  • 4093-35-0
  • C14H22BrN3O2
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