(3-BROMOBENZYL)METHYLAMINE
- Product Name
- (3-BROMOBENZYL)METHYLAMINE
- CAS No.
- 67344-77-8
- Chemical Name
- (3-BROMOBENZYL)METHYLAMINE
- Synonyms
- (3-BROMOBENZYL)METHY;3-BROMO-N-METHYLAMINE;(3-BROMOBENZYL)METHYLAMINE;N-Methyl-3-bromobenzylamine;3-BROMO-N-METHYLBENZYLAMINE;(3-Bromobenzyl)methylamine95%;(3-Bromobenzyl)Methylamine 95%;3-Bromo-N-methylbenzylamine;(3-BroMophenyl)-N-MethylMethanaMine;[(3-bromophenyl)methyl](methyl)amine
- CBNumber
- CB1329230
- Molecular Formula
- C8H10BrN
- Formula Weight
- 200.08
- MOL File
- 67344-77-8.mol
(3-BROMOBENZYL)METHYLAMINE Property
- Boiling point:
- 231-232 °C(lit.)
- Density
- 1.461 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.5650(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- liquid
- pka
- 9.32±0.10(Predicted)
- color
- colourless
- Sensitive
- Air Sensitive
- InChIKey
- QCEANFBGRBLXHN-UHFFFAOYSA-N
- CAS DataBase Reference
- 67344-77-8
N-Bromosuccinimide Price
- Product number
- 631159
- Product name
- 3-Bromo-N-methylbenzylamine
- Purity
- 97%
- Packaging
- 1g
- Price
- $34.7
- Updated
- 2023/01/07
- Product number
- 631159
- Product name
- 3-Bromo-N-methylbenzylamine
- Purity
- 97%
- Packaging
- 5g
- Price
- $104
- Updated
- 2023/01/07
- Product number
- B680878
- Product name
- (3-Bromobenzyl)methylamine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B680878
- Product name
- (3-Bromobenzyl)methylamine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR307051
- Product name
- 3-Bromo-N-methylbenzylamine
- Packaging
- 5g
- Price
- $63
- Updated
- 2021/12/16
(3-BROMOBENZYL)METHYLAMINE Chemical Properties,Usage,Production
Uses
(3-Bromobenzyl)methylamine is a useful intermediate used in the preparation of 2,4-diamino-6-(benzylmethylamino)quinazolines with antimalarial and antitumor activities.
Synthesis
3132-99-8
74-89-5
67344-77-8
Step B: At room temperature, 3-bromobenzaldehyde (47.5 mL, 0.4 mol) was dissolved in methanol (460 mL), followed by the addition of an aqueous solution of methylamine (35 mL, 0.4 mol, 40 wt% solution). The reaction mixture was cooled to 0 °C and sodium borohydride (22 g, 0.6 mol) was added in batches. The reaction mixture was kept stirred at 0 °C for 3.5 h and then gradually warmed up to room temperature. After completion of the reaction, the mixture was concentrated under reduced pressure and subsequently partitioned with dichloromethane and water. The aqueous layer was separated and washed with dichloromethane (3×). The organic phases were combined and washed sequentially with saturated sodium bicarbonate solution and brine, then dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure to afford the target product N-methyl-3-bromobenzylamine (76 g, 81%) as a clear oil. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.48 (d, J = 1.5 Hz, 1H), 7.40-7.37 (m, 1H), 7.24-7.16 (m, 2H), 3.73 (s, 2H), 2.45 (s, 3H).
References
[1] Patent: US2007/21408, 2007, A1. Location in patent: Page/Page column 94; 103
[2] Journal of Medicinal Chemistry, 1981, vol. 24, # 2, p. 140 - 145
[3] Patent: WO2009/149258, 2009, A2. Location in patent: Page/Page column 21; 48
[4] Patent: US2014/275101, 2014, A1. Location in patent: Paragraph 0072; 0145; 0146
[5] Patent: WO2015/127559, 2015, A1. Location in patent: Page/Page column 55; 56
(3-BROMOBENZYL)METHYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (3-BROMOBENZYL)METHYLAMINE manufacturers
- Product
- (3-BROMOBENZYL)METHYLAMINE 67344-77-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-04
- Product
- (3-BROMOBENZYL)METHYLAMINE 67344-77-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01