(4-BROMOBENZYL)METHYLAMINE
Uses- Product Name
- (4-BROMOBENZYL)METHYLAMINE
- CAS No.
- 699-03-6
- Chemical Name
- (4-BROMOBENZYL)METHYLAMINE
- Synonyms
- Aids107181;Aids-107181;(4-BROMOBENZYL)METHY;874-73-7 (Hydrochloride);(4-BROMOBENZYL)METHYLAMINE;4-BROMO-N-METHYLBENZYLAMINE;N-Methyl-4-bromobenzylamine;(4-Bromobenzyl)methylamine95%;(4-Bromobenzyl)Methylamine 95%;4-Bromo-N-methylbenzylamine 97%
- CBNumber
- CB3478655
- Molecular Formula
- C8H10BrN
- Formula Weight
- 200.08
- MOL File
- 699-03-6.mol
(4-BROMOBENZYL)METHYLAMINE Property
- Boiling point:
- 218-219 °C(lit.)
- Density
- 1.00 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.5650(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 9.52±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- Sensitive
- Air Sensitive
- InChIKey
- URFJXIULELMVHV-UHFFFAOYSA-N
- CAS DataBase Reference
- 699-03-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 631140
- Product name
- 4-Bromo-N-methylbenzylamine
- Purity
- 97%
- Packaging
- 1g
- Price
- $76.3
- Updated
- 2025/07/31
- Product number
- 631140
- Product name
- 4-Bromo-N-methylbenzylamine
- Purity
- 97%
- Packaging
- 5g
- Price
- $256
- Updated
- 2025/07/31
- Product number
- B700243
- Product name
- 1-(4-Bromophenyl)-N-methylmethanamine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB129598
- Product name
- (4-Bromobenzyl)methylamine hydrochloride
- Packaging
- 100mg
- Price
- $58
- Updated
- 2021/12/16
- Product number
- 071762
- Product name
- (4-Bromobenzyl)methylamine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
(4-BROMOBENZYL)METHYLAMINE Chemical Properties,Usage,Production
Uses
N-Methyl-4-bromobenzylamine is an important chemical raw material and pharmaceutical intermediate, such as being used to prepare benzofuran-based poly(ADP-ribose) polymerase (PARP) inhibitors.
Synthesis
1122-91-4
74-89-5
699-03-6
General procedure for the synthesis of N-methyl-4-bromobenzylamine: In an autoclave, 4-bromobenzaldehyde (2.08 g, 11.55 mmol) was mixed with a methanolic solution of 2 M methylamine (25 mL, 33.44 mmol) and the reaction was stirred at 65 °C for 4 hours. After completion of the reaction, cooled to room temperature, sodium borohydride (633 mg, 16.72 mmol) was added in batches. Stirring was continued for 30 minutes at room temperature, followed by vacuum concentration. The residue was dissolved in ethyl acetate (30 mL) and the organic layer was washed with saturated aqueous sodium bicarbonate. The aqueous phase was adjusted to pH 13 with a few drops of 1 N sodium hydroxide solution and then extracted twice with ethyl acetate. The organic extracts were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give N-methyl-4-bromobenzylamine as a colorless oil (2.04 g, 91% yield), which was used directly in the next step of the reaction.LC-MS analysis (Analytical Condition A, Zorbax SB-AQ columns, Acidic conditions): retention time t R = 0.61 min; [M + H]+ = 241.06 (acetonitrile adduct).
References
[1] Patent: WO2010/58353, 2010, A1. Location in patent: Page/Page column 77-78
[2] Patent: US2011/224210, 2011, A1. Location in patent: Page/Page column 54
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 78, # 1-4, p. 141 - 152
[4] Organic Letters, 2014, vol. 16, # 2, p. 358 - 361
(4-BROMOBENZYL)METHYLAMINE Preparation Products And Raw materials
Raw materials
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View Lastest Price from (4-BROMOBENZYL)METHYLAMINE manufacturers
- Product
- (4-BROMOBENZYL)METHYLAMINE 699-03-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01