STATIL

Product Name: STATIL
CAS No.: 72702-95-5
Chemical Name: STATIL
Synonyms: STATIL;MK-538;ICI-plc;ICI-128436;Ponalrestat;Ponalrestat (MK-538;Ponalrestat - Bio-X ?;Ponalrestat, 10 mM in DMSO;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID;Ponalrestat Statil
CBNumber: CB6193847
Molecular Formula: C17H12BrFN2O3
Formula Weight: 391.19
MOL File: 72702-95-5.mol

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STATIL Property

Melting point:: 184-186℃ (DEC.)
Density: 1.60
storage temp.: Store at RT
solubility: DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL
form: A crystalline solid
color: White to off-white
InChI: InChI=1S/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23)
InChIKey: LKBFFDOJUKLQNY-UHFFFAOYSA-N
SMILES: C12C=CC=CC=1C(=O)N(CC1=CC=C(Br)C=C1F)N=C2CC(=O)O

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3079
Product name: Ponalrestat
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $91.96
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3079
Product name: Ponalrestat
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $392
Updated: 2025/07/31

Cayman Chemical

Product number: 19189
Product name: Statil
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19189
Product name: Statil
Purity: ≥98%
Packaging: 10mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 19189
Product name: Statil
Purity: ≥98%
Packaging: 25mg
Price: $116
Updated: 2024/03/01

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STATIL Chemical Properties,Usage,Production

Description

Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with K_i values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F_2α by human cultured preadipocytes.

Uses

Inhibitor (aldose reductase).

Uses

Statil is a knon aldose reductase inhibitor which blocks the conversion of glucose to sorbitol. In addition it suppresses cell cancer growth

Definition

ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines.

Biological Activity

Potent aldose reductase inhibitor.

in vivo

Ponalrestat (ICI 128436; 10, 50 mg/kg; orally; daily; 8 weeks) reduces sorbitol accumulation indicating efficacy of aldose reductase inhibition^[3].

Animal Model:	Adult female Sprague-Dawley rats^[3]
Dosage:	10, 50 mg/kg
Administration:	Orally; daily; 8 weeks
Result:	Reduced sorbitol accumulation.

References

[1] WALTER H.J. WARD . Ponalrestat: A potent and specific inhibitor of aldose reductase[J]. Biochemical pharmacology, 1990, 39 2: Pages 337-346. DOI: 10.1016/0006-2952(90)90033-h
[2] DONNA J. OTTER Russell C W. The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats[J]. British Journal of Pharmacology, 1994, 113 2: 576-580. DOI: 10.1111/j.1476-5381.1994.tb17028.x
[3] ANDRéANNE MICHAUD. Prostaglandin (PG) F2 alpha synthesis in human subcutaneous and omental adipose tissue: modulation by inflammatory cytokines and role of the human aldose reductase AKR1B1.[J]. PLoS ONE, 2014: e90861. DOI: 10.1371/journal.pone.0090861

STATIL Preparation Products And Raw materials

Raw materials

Preparation Products

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STATIL Suppliers

China 81 Europe 2 Germany 2 India 1 United Kingdom 2 United States 11 Global 99

Suzhou Ran enzyme Biotechnology Co., Ltd.

Tel: 0512-0512-62793604 18015430729
Fax: 0512-62793604
Email: 116667374@qq.com
Country: China
ProdList: 127
Advantage: 58

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
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ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9119
Advantage: 58

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View Lastest Price from STATIL manufacturers

Career Henan Chemical Co

Product: STATIL;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID; 72702-95-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

72702-95-5, STATILRelated Search:

STATIL BENZYL-(2-FLUORO-BENZYL)-AMINE 4-BROMO-2-FLUOROBENZYLAMINE 1,1-Dibenzylhydrazine (4-BROMOBENZYL)METHYLAMINE (2-FLUORO-BENZYL)-HYDRAZINE (3-METHYL-4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID (4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETIC ACID 3-(2-FORMYLPHENYL)PROPANOIC ACID CHEMBRDG-BB 5937785 4-BROMO-BENZYL-HYDRAZINE 4-Bromo-2-fluorotoluene 4-ETHYL-2H-PHTHALAZIN-1-ONE

STATIL

[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID

Ponalrestat

3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL)

3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid

ICI-128436

ICI-plc

MK-538

2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid

Ponalrestat Statil

Ponalrestat (MK-538

ICI128436,ICI 128436,glucose,ALR,AKR1B1,Ponalrestat,Inhibitor,Aldose Reductase,conversion,inhibit,sorbitol,ICI-128436,orally,noncompetitive,ALR2,ALR1

Ponalrestat, 10 mM in DMSO

Ponalrestat - Bio-X ?

72702-95-5

C17H12BrFN2O3

Inhibitors