STATIL
- Product Name
- STATIL
- CAS No.
- 72702-95-5
- Chemical Name
- STATIL
- Synonyms
- STATIL;MK-538;ICI-plc;ICI-128436;Ponalrestat;Ponalrestat (MK-538;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID;Ponalrestat Statil;3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL);2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid
- CBNumber
- CB6193847
- Molecular Formula
- C17H12BrFN2O3
- Formula Weight
- 391.19
- MOL File
- 72702-95-5.mol
STATIL Property
- Melting point:
- 184-186℃ (DEC.)
- Density
- 1.60
- storage temp.
- Store at RT
- solubility
- DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL
- form
- A crystalline solid
- color
- White to off-white
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19189
- Product name
- Statil
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19189
- Product name
- Statil
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 19189
- Product name
- Statil
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 19189
- Product name
- Statil
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- S684550
- Product name
- Statil
- Packaging
- 25mg
- Price
- $95
- Updated
- 2021/12/16
STATIL Chemical Properties,Usage,Production
Description
Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.
Uses
Inhibitor (aldose reductase).
Uses
Statil is a knon aldose reductase inhibitor which blocks the conversion of glucose to sorbitol. In addition it suppresses cell cancer growth
Definition
ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines.
Biological Activity
Potent aldose reductase inhibitor.
STATIL Preparation Products And Raw materials
Raw materials
Preparation Products
STATIL Suppliers
- Tel
- --
- Fax
- --
- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
- 66
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from STATIL manufacturers
- Product
- STATIL;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID; 72702-95-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24