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STATIL

Product Name
STATIL
CAS No.
72702-95-5
Chemical Name
STATIL
Synonyms
STATIL;MK-538;ICI-plc;ICI-128436;Ponalrestat;Ponalrestat (MK-538;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID;Ponalrestat Statil;3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL);2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid
CBNumber
CB6193847
Molecular Formula
C17H12BrFN2O3
Formula Weight
391.19
MOL File
72702-95-5.mol
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STATIL Property

Melting point:
184-186℃ (DEC.)
Density 
1.60
storage temp. 
Store at RT
solubility 
DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL
form 
A crystalline solid
color 
White to off-white
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19189
Product name
Statil
Purity
≥98%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19189
Product name
Statil
Purity
≥98%
Packaging
10mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
19189
Product name
Statil
Purity
≥98%
Packaging
25mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
19189
Product name
Statil
Purity
≥98%
Packaging
50mg
Price
$139
Updated
2024/03/01
TRC
Product number
S684550
Product name
Statil
Packaging
25mg
Price
$95
Updated
2021/12/16
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STATIL Chemical Properties,Usage,Production

Description

Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.

Uses

Inhibitor (aldose reductase).

Uses

Statil is a knon aldose reductase inhibitor which blocks the conversion of glucose to sorbitol. In addition it suppresses cell cancer growth

Definition

ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines.

Biological Activity

Potent aldose reductase inhibitor.

STATIL Preparation Products And Raw materials

Raw materials

Preparation Products

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STATIL Suppliers

China 68 Europe 2 Germany 2 India 1 United Kingdom 2 United States 11 Global 86
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View Lastest Price from STATIL manufacturers

Career Henan Chemical Co
Product
STATIL;[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID; 72702-95-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-24

72702-95-5, STATILRelated Search:

STATIL BENZYL-(2-FLUORO-BENZYL)-AMINE 4-BROMO-2-FLUOROBENZYLAMINE 1,1-Dibenzylhydrazine (4-BROMOBENZYL)METHYLAMINE (2-FLUORO-BENZYL)-HYDRAZINE (3-METHYL-4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID (4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETIC ACID 3-(2-FORMYLPHENYL)PROPANOIC ACID CHEMBRDG-BB 5937785 4-BROMO-BENZYL-HYDRAZINE 4-Bromo-2-fluorotoluene 4-ETHYL-2H-PHTHALAZIN-1-ONE

  • STATIL
  • [3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID
  • Ponalrestat
  • 3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL)
  • 3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid
  • ICI-128436
  • ICI-plc
  • MK-538
  • 2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid
  • Ponalrestat Statil
  • Ponalrestat (MK-538
  • ICI128436,ICI 128436,glucose,ALR,AKR1B1,Ponalrestat,Inhibitor,Aldose Reductase,conversion,inhibit,sorbitol,ICI-128436,orally,noncompetitive,ALR2,ALR1
  • 72702-95-5
  • C17H12BrFN2O3
  • Inhibitors