ChemicalBook > CAS DataBase List > 3-Hydroxy-N-methyl-3-phenyl-propylamine

3-Hydroxy-N-methyl-3-phenyl-propylamine

Product Name
3-Hydroxy-N-methyl-3-phenyl-propylamine
CAS No.
42142-52-9
Chemical Name
3-Hydroxy-N-methyl-3-phenyl-propylamine
Synonyms
3-(METHYLAMINO)-1-PHENYLPROPAN-1-OL;3-METHYLAMINO-1-PHENYLPROPANOL;N-METHYL-3-PHENYL-3-HYDROXYPROPYLAMINE;α-[2-(MethyL;Compound PDK0217;Atomoxetine EP Imp H;Atomoxetine USP RC A;Fluoxetine Impurity 1;Fluoxetine EP IMpurity A;Fluoxertine EP impurity A
CBNumber
CB6345561
Molecular Formula
C10H15NO
Formula Weight
165.23
MOL File
42142-52-9.mol
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3-Hydroxy-N-methyl-3-phenyl-propylamine Property

Melting point:
64 °C
Boiling point:
170 °C / 31mmHg
Density 
1.017±0.06 g/cm3(Predicted)
vapor pressure 
0.037Pa at 25℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Soluble), Methanol (Slightly)
pka
14.24±0.20(Predicted)
form 
Solid
color 
Off-White to Pale Yellow
InChI
InChI=1S/C10H15NO/c1-11-8-7-10(12)9-5-3-2-4-6-9/h2-6,10-12H,7-8H2,1H3
InChIKey
XXSDCGNHLFVSET-UHFFFAOYSA-N
SMILES
C(C1C=CC=CC=1)(O)CCNC
LogP
0.98
CAS DataBase Reference
42142-52-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36/37
WGK Germany 
3
HS Code 
2922199695
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0002201
Product name
Fluoxetine impurity A
Purity
CRS, European Pharmacopoeia (EP) Reference Standard
Packaging
15 mg
Price
$167
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR2840
Product name
Atomoxetine Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
25MG
Price
$585.2
Updated
2025/07/31
Sigma-Aldrich
Product number
463477
Product name
α-[2-(Methylamino)ethyl]benzyl alcohol
Purity
97%
Packaging
1g
Price
$32.3
Updated
2025/07/31
Sigma-Aldrich
Product number
1044470
Product name
Atomoxetine Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
10mg
Price
$1200
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0002201
Product name
Fluoxetine impurity A
Purity
CRS, European Pharmacopoeia (EP) Reference Standard
Packaging
Y0002201
Price
$156
Updated
2024/03/01
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3-Hydroxy-N-methyl-3-phenyl-propylamine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

α-[2-(Methylamino)ethyl]benzyl Alcohol (Fluoxetine EP Impurity A(Atomoxetine Related Compound A)) is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.This compound is found as an impurity in fluoxetine (F597100).

Uses

3-Hydroxy-N-methyl-3-phenyl-propylamine is an aromatic amino alcohol used as an initiator in radical addition reactions with tetrahalomethanes.

Synthesis

3-Hydroxy-N-methyl-3-phenyl-propylamine is one of important intermediate of preparation fluoxetine Hydrochloride. Up to now, the method for preparing N-methyl-3-phenyl-3-hydroxy-propylamine is mainly divided into three kinds; the first kind of be replace (halogen with 3-, dialkylamine, amido or ethoxycarbonyl) Propiophenone be starting raw material, earlier after reduction, the 1-phenylpropyl alcohol that 3-is replaced is converted into 3-Hydroxy-N-methyl-3-phenyl-propylamine again; Second kind and being: the different azoles alkane of 2-methyl-5-phenyl is carried out reductive ring open makes target compound; The third be: with getting the 1-phenylpropyl alcohol that 3-replaces behind epoxy styrene and the derivative reductive ring open thereof, be translated into target compound earlier.

References

[1] Patent: CN103992236, 2016, B. Location in patent: Paragraph 0051;0054; 0055
[2] Angewandte Chemie - International Edition, 2005, vol. 44, # 11, p. 1687 - 1689

3-Hydroxy-N-methyl-3-phenyl-propylamine Preparation Products And Raw materials

Raw materials

Preparation Products

Fluoxetine
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3-Hydroxy-N-methyl-3-phenyl-propylamine Suppliers

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View Lastest Price from 3-Hydroxy-N-methyl-3-phenyl-propylamine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-Hydroxy-N-methyl-3-phenyl-propylamine 42142-52-9
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000KG
Release date
2021-07-22
Hebei Chuanghai Biotechnology Co., Ltd
Product
3-Hydroxy-N-methyl-3-phenyl-propylamine 42142-52-9
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-29
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
3-Hydroxy-N-methyl-3-phenyl-propylamine 42142-52-9
Price
US $99.00-66.00/kg
Min. Order
0.001kg
Purity
99%
Supply Ability
5000
Release date
2024-08-09

42142-52-9, 3-Hydroxy-N-methyl-3-phenyl-propylamineRelated Search:

Benzyl benzoate Methyl acrylate Ethyl acetate Trimethylamine Benzyl bromide 1-Propanol Ethanol PHENYL VALERATE Ethylparaben Benzhydrylamine CHLOROPHOSPHONAZO III Benzyl alcohol Methylparaben trimethylamine oxide 1-Phenyl-1-propanol Kresoxim-methyl 3-Phenyl-1-propanol Flunixin meglumine

  • ALPHA-(2-METHYLAMINO)-ETHYLBENZENEMETHANOL
  • ALPHA-[2-(METHYLAMINO)ETHYL]BENZYL ALCOHOL
  • 3-HYDROXY-N-METHYL-3-PHENYLPROPYLAMINE
  • 3-METHYLAMINO-1-PHENYLPROPANOL
  • 3-(METHYLAMINO)-1-PHENYLPROPAN-1-OL
  • 3-METHYLAMINO-1-PHENYL-1-PROPANOL
  • N-METHYL-3-PHENYL-3-HYDROXYPROPYLAMINE
  • N-METHYL-3-HYDROXY-3-PHENYL PROPYLAMINE
  • (RS)-3-MethylaMino-1-Phenyl-Propan-1-ol
  • 3-Hydroxy-N-Methyl-3-phenyl-propylaMin
  • alpha-[2-(MethylaMino)ethyl]benzyl alcohol 97%
  • Fluoxertine EP impurity A -C
  • (RS)-3-Methylamino-1-phenyl-1-propanol
  • Fluoxertine EP impurity A
  • 3-(methylamino)-1-phenylpropan-1-ol Oxalate
  • Fluoxetine Impurity 1(EP-A)
  • Atomoxetine Impurity 8(Atomoxetine EP Impurity H)
  • Fluoxetine Hydrochloride Impurity Ⅰ：Fluoxetine EP Impurity A
  • Fluoxetine Impurity 1
  • Atomoxetine EP Imp H
  • A-[2-(Methylamino)Ethyl]Benzenemethanol
  • 3-N-methyl-1-phenyl-propanol
  • BENZENEMETHANOL,A-[2-(METHYLAMINO)ETHYL]
  • 3-methylamino-1-phenylpropano
  • α-[2-(Methylamino)ethyl]benzenemethanol
  • N-Methyl-3-Phenyl-3-Hydroxypropylamin
  • 3-Methylamino-1-phenylpropane-1-ol
  • 3-Hydroxy-N-methyl-3-phenyl-pr
  • α-[2-(methylamino)ethyl]benzyl alcohol
  • 1-PHENYL-3-METHYLAMINO-1-PROPANOL
  • PHENYL METHYL AMINO PROPANOL
  • Propanol, 3-methylamino-1-phenyl
  • Benzenemethanol, α-[2-(methylamino)ethyl]-
  • Benzenemethanol, alpha-[2-(methylamino)ethyl]-
  • 1-Phenyl-3-(methylamino)propane-1-ol
  • N-Methyl-3-hydroxy-3-phenyl-1-propanamine
  • N-Methyl-3-phenyl-3-hydroxypropylamine,97%
  • N-Methyl 3-phenyl-3-hydroxy-1-propanaMine
  • N-(3-Hydroxy-3-phenylpropyl)MethylaMine
  • N-Methyl-N-(3-hydroxy-3-phenylpropyl)aMine
  • 3-Hydroxy-N-methyl-3-phenylpropylamine 3-(Methylamino)-1-phenylpropanol
  • Fluoxetine EP IMpurity A
  • Methyl({3-[3-(2-Methylphenoxy)phenyl]propyl})aMine
  • 3-(Methylamino)-1-Phenyl-1-Ppropanol
  • α-[2-(Methylamino)ethyl]benzylAlcohol&gt
  • Fluoxetine EP Impurity A (Atomoxetine EP Impurity H)
  • Atomoxetine USP RC A
  • α-[2-(MethyL
  • 3-Hydroxy-N-methyl-3-phenyl-propylamine USP/EP/BP
  • Fluoxetine intermediate，3-Hydroxy-N-methyl-3-phenyl- propylamine
  • Hydroxy-N-methyl-3-phenyl-propylamine
  • ALPHA-[2-(METHYLAMINO)ETHYL]BENZYL
  • Atomoxetine EP Impurity H/ Atomoxetine Related Compound A
  • 3-Hydroxy-N-Methyl-3-Phenyl-Propylamine(42142-52-9)
  • (1RS)-3-(Methylamino)-1-phenylpropan-1-ol
  • Atomoxetine Related Compound A (3-(Methylamino)-1-phenylpropan-1-ol) (1044470)
  • Compound PDK0217
  • Atomoxetine EP impurity H（Fluoxetine EP Impurity A）