ChemicalBook > CAS DataBase List > N'-Nitro-L-arginine-methyl ester hydrochloride

N'-Nitro-L-arginine-methyl ester hydrochloride

Product Name
N'-Nitro-L-arginine-methyl ester hydrochloride
CAS No.
51298-62-5
Chemical Name
N'-Nitro-L-arginine-methyl ester hydrochloride
Synonyms
L-NAME;L-NAME HCL;H-Ala(NO2)-OMeHCl;H-Ala(No2)-Omecl;H-Arg(NO2)-OMe¤HC;H-Aeg(NO2)-OMe.HCL;L-Arg(NO2)-Ome·HCl;H-Arg(NOZ)-OMe.HCl;H-ARG(NO2)-OME HCL;H-L-Arg(NO2)-OMe*HCl
CBNumber
CB6350079
Molecular Formula
C7H16ClN5O4
Formula Weight
269.69
MOL File
51298-62-5.mol
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N'-Nitro-L-arginine-methyl ester hydrochloride Property

Melting point:
157-161 °C (dec.)
alpha 
14.5 º (c=3, CH3OH)
refractive index 
15 ° (C=3, MeOH)
RTECS 
RM2982570
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
white to off-white
Water Solubility 
almost transparency
BRN 
3744166
InChIKey
QBNXAGZYLSRPJK-JEDNCBNOSA-N
CAS DataBase Reference
51298-62-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
HS Code 
29299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N5751
Product name
Nω-Nitro-L-arginine methyl ester hydrochloride
Purity
≥98% (TLC), powder
Packaging
1g
Price
$53.6
Updated
2024/03/01
Sigma-Aldrich
Product number
483125-M
Product name
NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem
Packaging
100mg
Price
$68.4
Updated
2024/03/01
TCI Chemical
Product number
N0661
Product name
Nomega-Nitro-L-arginine Methyl Ester Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$85
Updated
2024/03/01
TCI Chemical
Product number
N0661
Product name
Nomega-Nitro-L-arginine Methyl Ester Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$227
Updated
2024/03/01
Alfa Aesar
Product number
H63666
Product name
Nomega-Nitro-L-arginine methyl ester hydrochloride, 98%
Packaging
5g
Price
$105
Updated
2024/03/01
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N'-Nitro-L-arginine-methyl ester hydrochloride Chemical Properties,Usage,Production

Description

L-NAME requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor (L-NNA). L-NNA exhibits some selectivity for inhibition of neuronal and endothelial isoforms. It exhibits Ki values of 15 nM, 39 nM, and 4.4 μM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively. The reported Ki value for the inhibition of iNOS ranges from 4-65 μM. L-NAME inhibits cGMP formation in endothelial cells with an IC50 of 3.1 μM (in the presence of 30 μM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC50 of 0.54 μM.

Chemical Properties

Crystalline

Uses

Nitroarginine Methyl Ester Hydrochloride is used in the synthesis of N/CD13 inhibitors playing an important role in tumor invasion, metastatsis and angiogenesis. Also used in the preparation of spirocyclic lactam as a type II’ β-turn inducer.

Definition

ChEBI: A hydrochloride obtained by combining Ngamma-nitro-L-arginine methyl ester with one equivalent of hydrochloric acid.

General Description

More soluble analog of arginine and a competitive, slowly reversible inhibitor of endothelial nitric oxide synthase (IC50 = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC50 = 400 nM).

Biological Activity

NO synthase inhibitor.

Biochem/physiol Actions

Primary TargeteNOS

storage

Room temperature

N'-Nitro-L-arginine-methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N'-Nitro-L-arginine-methyl ester hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
N'-Nitro-L-arginine-methyl ester hydrochloride 51298-62-5
Price
US $0.00/g/Bag
Min. Order
1g
Purity
98%min
Supply Ability
1000g
Release date
2021-08-23
Shaanxi Dideu Medichem Co. Ltd
Product
N'-Nitro-L-arginine-methyl ester hydrochloride 51298-62-5
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13
Career Henan Chemical Co
Product
N'-Nitro-L-arginine-methyl ester hydrochloride 51298-62-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15

51298-62-5, N'-Nitro-L-arginine-methyl ester hydrochlorideRelated Search:

L-Alanine methyl ester hydrochloride L-Arginine hydrochloride Bensulfuron methyl L(+)-Arginine Topotecan hydrochloride ARGINASE Methyl acrylate Kresoxim-methyl Methylparaben Arginine Methyl Parathion-methyl arginine aspirin penoxalin (wssa former name) Methyl bromide CHEMICAL NAME: 1,3,5-UNDECATRIENE Lanolin, ethoxylated propoxylated mittlere Molmasse 5000 - 5400 g/mol (Generic CA index name for polymer) chlorthion (common name not adopted by ISO) O-(3-chloro-4-nitrophenyl) O,O-dimethyl phosphorothioate

  • L-NG-Nitroarginine Methyl Ester (L-NAME)
  • Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME)
  • L-Arg(NO2)-Ome·HCl
  • H-Aeg(NO2)-OMe.HCL
  • (S)-Methyl 2-amino-5-(3-nitroguanidino)-pentanoate hydrochloride
  • NG-nitro-L-Arg-OMe*HCl
  • L-Ornithine, N5-[imino(nitroamino)methyl]-, methyl ester, hydrochloride (1:1)
  • 2-(4-amino-5-oxohexyl)-1-nitroguanidine hydrochloride
  • N5-NITRO-L-ARGININE METHYL ESTER DIHYDROCHLORIDE
  • Nitro-L-arginineMethylEsterHCl
  • NW-NITRO-L-ARGININEMETHYLESTERHYDROCHLORIDE
  • H-Ala(NO2)-OMe hydrochloride
  • NITROARGININEMETHYLESTERHYDROCHLORIDE
  • H-L-Arg(NO2)-OMe*HCl
  • H-Arg(NOZ)-OMe.HCl
  • methyl N5-[imino(nitroamino)methyl]-L-ornithine monohydrochloride
  • H-Ala(NO2)-OMeHCl
  • H-Ala(No2)-Omecl
  • ω-Nitro-L-arginine methyl·hydrochloric acid
  • NG-Nitro-L-arginine-methyl ester hydrochloride,98%
  • Nω-Nitro-L-arginine methyl ester hydrochloride ,98%
  • Nω-Nitro-L-arginine methyl ester hydrochloride,L-NAME hydrochloride
  • L-Ornithine, N5-[iMino(nitroaMino)Methyl]-, Methyl ester, Monohydrochloride
  • H-Arg(NO2)-OMe·HCl N-ω-Nitro-L-arginine Methyl ester hydrochloride
  • NG-Nitro-L-arginine-Methyl ester hydrochloride, 98% 5GR
  • N(gamma)-nitro-L-arginine methyl ester hydrochloride
  • Nω-Nitro-L-Arginine Methyl ester hydrochloride, 98%, a nonselective inhibitor of nitric oxide synthetases (NOS)
  • NG-Nitro-L-arginine Methyl Ester, Hydrochloride - CAS 51298-62-5 - Calbiochem
  • L-NAME hydrochloride (NG-Nitroarginine methyl ester hydrochloride)
  • NG-Nitroarginine methyl ester hydrochloride
  • methyl (2S)-2-amino-5-(N'-nitrocarbamimidamido)pentanoate hydrochloride
  • H-Arg(NO2)-OMe¤HC
  • L-NAME hydrochloride H-Arg(NO2)-OMe·HCl
  • L-NAME
  • L-NAME HCL
  • L-NAME HYDROCHLORIDE
  • L-NG-NITROARGININE METHYL ESTER HCL
  • L-NG-NITROARGININE METHYL ESTER HYDROCHLORIDE
  • H-ARG(NO2)-OME HCL
  • H-ARG(NO2)-OME HYDROCHLORIDE
  • ARGININE(NO2)-OME HCL
  • H-Arg(NO<SUB>2</SUB>)-OMe·HCl
  • N<SUB>ω</SUB>-Nitro-L-arginine methyl ester hydrochloride
  • S(+)-N5-[IMINO(NITROAMINO)METHYL]-L-ORNITHINE METHYL ESTER HYDROCHLORIDE
  • N-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE
  • N-OMEGA-NO2-L-ARG-OME, HCL
  • N-OMEGA-NO2-L-ARG-OME, HYDROCHLORIDE
  • N-OMEGA-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE
  • NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE
  • NG-NO2-L-ARG-OME, HCL
  • NG-NO2-L-ARG-OME, HYDROCHLORIDE
  • NG-NITRO-L-ARGININE-METHYL ESTER HCL
  • NG-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE
  • N(G)-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE SALT
  • N5-[IMINO(NITROAMINO)METHYL]-L-ORNITHINE, METHYL ESTER, MONOHYDROCHLORIDE
  • Nω-Nitro-L-arginineMethylEsterHydrochloride&gt
  • N'-Nitro-L-arginine-methyl ester hydrochloride USP/EP/BP
  • Argatroban Impurity 75 HCl