22(R)-HYDROXYCHOLESTEROL

Product Name: 22(R)-HYDROXYCHOLESTEROL
CAS No.: 22348-64-7
Chemical Name: 22(R)-HYDROXYCHOLESTEROL
Synonyms: C05502;22(R)-OH-CH;22BF-HYDROXYCHOLESTEROL;22β-Hydroxy Cholesterol;Chlorambucil Impurity 9;22(S)-HYDROXYCHOLESTEROL;22BETA-HYDROXYCHOLESTEROL;(5-Cholestene-322(S)-diol);5-CHOLESTEN-3β, 22(S)-DIOL;22-HYDROXYCHOLESTEROL (22R)
CBNumber: CB6350291
Molecular Formula: C27H46O2
Formula Weight: 402.65
MOL File: 22348-64-7.mol

More

Less

22(R)-HYDROXYCHOLESTEROL Property

storage temp.: Store at -20°C
solubility: DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
form: A crystalline solid

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H5884
Product name: 22(S)-Hydroxycholesterol
Packaging: 5mg
Price: $196
Updated: 2025/07/31

Sigma-Aldrich

Product number: H5884
Product name: 22(S)-Hydroxycholesterol
Packaging: 10mg
Price: $338
Updated: 2023/06/20

Cayman Chemical

Product number: 21399
Product name: 22(S)-hydroxy Cholesterol
Purity: ≥95%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 21399
Product name: 22(S)-hydroxy Cholesterol
Purity: ≥95%
Packaging: 5mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 21399
Product name: 22(S)-hydroxy Cholesterol
Purity: ≥95%
Packaging: 10mg
Price: $257
Updated: 2024/03/01

More

Less

22(R)-HYDROXYCHOLESTEROL Chemical Properties,Usage,Production

Uses

The 22S-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity.

Definition

ChEBI: An oxysterol that is the 22S-hydroxy derivative of cholesterol.

Biological Activity

22(S)-Hydroxycholesterol modulates the lipid and glucose metabolism by acting on liver X receptors. It has the potential to reduce lipogenesis and the accumulation of lipid in hepatocytes, myotubes and non-adipose tissue.

in vivo

Cholest-5-ene-3?,22(S)-diol (30 mg/kg; p.o.; added in diet, treated for 3 weeks) reduces body weight gain and abolishes high-fat diet-induced increase of triacylglycerol (TAG) levels in serum^[2].

Pharmacokinetic Analysis in Rats^[2]

Route	Dose (mg/kg)	C_max (ng/mL)	T_max (h)	AUC_t (ng·h/mL)	AUC (ng·h/mL)	T_1/2 (h)	Extent of tritium exchange (%)
i.v.	50	22.4	0.08	174	195	8.1	2.8
p.o.	50	7.5	4	95.2	104	6.4	1.2

Animal Model:	Male rats injected with Pentobarbital (20 mg, 50 mg/mL; i.p.)^[2]
Dosage:	30 mg/kg/day
Administration:	Oral gavage; 3 weeks consecutively
Result:	Decreased body weight gain significantly after 1 week treatment. Increased gene expression of Ucp3 and Cpt2 in liver and skeletal muscle, and increased protein level of Ucp3 in skeletal muscle after 3 weeks treatment.

22(R)-HYDROXYCHOLESTEROL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

22(R)-HYDROXYCHOLESTEROL Suppliers

Canada 1 China 47 France 1 Switzerland 1 United States 12 Global 62

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Avanti Polar Lipids, Inc.

Tel: --
Fax: --
Email: info@avantilipids.com
Country: United States
ProdList: 610
Advantage: 79

American Radiolabeled Chemicals, Inc.

Tel: --
Fax: --
Email: arcinc@arc-inc.com
Country: United States
ProdList: 2608
Advantage: 60

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

Research Plus, Inc.

Tel: --
Fax: --
Email: respls@aol.com
Country: United States
ProdList: 3674
Advantage: 51

Novus Biologicals, Inc.

Tel: --
Fax: --
Email: novus@novusbio.com
Country: United States
ProdList: 175
Advantage: 77

Medical Isotopes

Tel: --
Fax: --
Email: stohler@medicalisotopes.com
Country: United States
ProdList: 6181
Advantage: 68

Steraloids Inc.

Tel: --
Fax: --
Email: sales@steraloids.com
Country: United States
ProdList: 2357
Advantage: 68

22348-64-7, 22(R)-HYDROXYCHOLESTEROLRelated Search:

5-CHOLESTENE 22(R)-HYDROXYCHOLESTEROL 27-Hydroxycholesterol

CHOLEST-5-ENE-3BETA,22R-DIOL

5-CHOLESTENE-3BETA,22[R]-DIOL

5-CHOLESTENE-3BETA,22[S]-DIOL

5-CHOLESTEN-3-BETA, 22(R)-DIOL

5-CHOLESTEN-3-BETA, 22(S)-DIOL

3BETA,22BETA-DIHYDROXY-5-CHOLESTENE

22[S]-Hydroxycholesterol (not deuterated)

(3S,8S,9S,10R,13R,14S,17R)-17-[(2S,3R)-3-hydroxy-6-methyl-heptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

(5-Cholestene-322(S)-diol)

22(S)-HYDROXYCHOLESTEROL

22(R)-OH-CH

22BETA-HYDROXYCHOLESTEROL

22BF-HYDROXYCHOLESTEROL

22-HYDROXYCHOLESTEROL (22R)

22ALPHA-DIHYDROXY-5-CHOLESTENE

22-ALPHA-HYDROXYCHOLESTEROL

22β-Hydroxycholesterol, 5-Cholestene-3β,22(S)-diol

C05502

(20S,22S)-Cholest-5-ene-3β,22-diol

(22S)-22-Hydroxycholesterol

(22S)-Cholest-5-ene-3β,22-diol

(3β,22S)-Cholest-5-ene-3,22-diol

Cholest-5-ene-3β,22(S)-diol

CHOLEST-5-ENE-3,22(S)-DIOL;22(S)-HYDROXYCHOLESTEROL

Cholest-5-ene-3,22-diol, (3β,22S)-

22β-Hydroxy Cholesterol

5-CHOLESTEN-3β, 22(S)-DIOL

22(S)-hydroxy Cholesterol (22β-hydroxy Cholesterol)

Chlorambucil Impurity 9

Cholest-5-ene-3?,22(S)-diol

22348-64-7

71954-98-2

BioChemical

Biochemicals and Reagents

Sterols

Lipids

Cholesterol and Derivatives

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Steroids

Hydroxycholesterol