ChemicalBook > CAS DataBase List > 4-(2-Pyridinyl)benzaldehyde

4-(2-Pyridinyl)benzaldehyde

Product Name
4-(2-Pyridinyl)benzaldehyde
CAS No.
127406-56-8
Chemical Name
4-(2-Pyridinyl)benzaldehyde
Synonyms
4-(PYRIDIN-2-YL)BENZALDEHYDE;4-(2-PYRIDYL)BENZALDEHYDE;AKOS BAR-0490;4-Pyridylenzaldehyde;Atazanavir Impurity 12;Pyridinyl Benzaldehyde;Azanavir EP Impurity B;Atazanavir EP Impurity B;-(2-Pyridyl)benzaldehyde;Atazanavir EP Impurity 6
CBNumber
CB6351081
Molecular Formula
C12H9NO
Formula Weight
183.21
MOL File
127406-56-8.mol
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4-(2-Pyridinyl)benzaldehyde Property

Melting point:
50-52 °C(lit.)
Boiling point:
340.4±25.0 °C(Predicted)
Density 
1.147±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in Chloroform
pka
3.97±0.25(Predicted)
form 
Solid
color 
White to Off-White Waxy
CAS DataBase Reference
127406-56-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37-36/37/39-22
WGK Germany 
3
Hazard Note 
Harmful
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
489387
Product name
4-(2-Pyridyl)benzaldehyde
Purity
97%
Packaging
5g
Price
$73.6
Updated
2023/06/20
Sigma-Aldrich
Product number
572411
Product name
4-(2-Pyridyl)benzaldehyde
Purity
99%
Packaging
5g
Price
$51.5
Updated
2022/05/15
TCI Chemical
Product number
P1671
Product name
4-(2-Pyridyl)benzaldehyde
Purity
>95.0%(GC)(T)
Packaging
1g
Price
$16
Updated
2025/07/31
TCI Chemical
Product number
P1671
Product name
4-(2-Pyridyl)benzaldehyde
Purity
>95.0%(GC)(T)
Packaging
5g
Price
$63
Updated
2025/07/31
TRC
Product number
P992125
Product name
4-(2-Pyridinyl)benzaldehyde
Packaging
10g
Price
$235
Updated
2021/12/16
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4-(2-Pyridinyl)benzaldehyde Chemical Properties,Usage,Production

Chemical Properties

White Waxy Solid

Uses

Reactive metabolite of atazanavir. Atazanavir Impurity; Pyridinyl Benzaldehyde impurity

General Description

4-(2-Pyridyl)benzaldehyde is a p-substituted benzaldehyde.

Synthesis

109-04-6

87199-17-5

127406-56-8

General procedure for the synthesis of 4-(2-pyridyl)-benzaldehyde from 2-bromopyridine and 4-formylphenylboronic acid: 1.1 equiv. of the brominated derivatives (13- of 2-bromopyridine and 14- of 1-bromo-4-nitrobenzene) of 4-formylphenylboronic acid, Pd(OAc)2 (2 mol%), and PPh3 (4 mol%) were added to a Schlenk flask. Methanol/THF (1:1, 2 mL/mmol) and 2 eq. of KOH were added under an inert atmosphere. the reaction system was stirred at 60 °C for 24 h. The reaction system was then purified by column chromatography. The target compounds were purified by column chromatography (eluent: cyclohexane/EtOAc, 9:1) to afford the products 13a and 14a in 80% and 75% yields, respectively.

References

[1] European Journal of Organic Chemistry, 2008, # 12, p. 2049 - 2055
[2] Angewandte Chemie - International Edition, 2015, vol. 54, # 47, p. 14103 - 14107
[3] Angew. Chem., 2015, vol. 127, # 47, p. 14309 - 14313,5
[4] Organic and Biomolecular Chemistry, 2013, vol. 11, # 39, p. 6806 - 6813
[5] European Journal of Organic Chemistry, 2014, vol. 2014, # 27, p. 5901 - 5905

4-(2-Pyridinyl)benzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(2-Pyridinyl)benzaldehyde manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
4-(2-Pyridinyl)benzaldehyde 127406-56-8
Price
US $0.23/KG
Min. Order
1KG
Purity
99
Supply Ability
3000ton
Release date
2021-11-23
Dideu Industries Group Limited
Product
4-(2-Pyridinyl)benzaldehyde 127406-56-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-(2-Pyridinyl)benzaldehyde 127406-56-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

127406-56-8, 4-(2-Pyridinyl)benzaldehydeRelated Search:

Benzaldehyde 2-Nitrobenzaldehyde 2-Pyridinecarboxaldehyde 4-Hydroxybenzaldehyde 4-Dimethylaminobenzaldehyde H-GAMMA-GLU-GLU-OH Nalpha-Cbz-L-Arginine DIANTIPYRYLMETHANE LDAO 1-Pyrrolidino-1-cyclopentene N-EPSILON-ACETYL-L-LYSINE N-ALPHA-BENZOYL-L-ARGININE 1-Methyl-2-pyrrolidineethanol OIL BLUE N N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) 2-(2-Aminoethyl)-1-methylpyrrolidine 4-(2-Pyridyl)benzoic acid N6-Cbz-L-Lysine

  • Atazanavir EP Impurity B
  • Pyridinyl Benzaldehyde
  • Atazanavir Impurity 12
  • Atazanavir Impurity 16 (Pyridinyl Benzaldehyde)
  • Benzaldehyde, 4-(2-pyridinyl)-
  • 4-(2-Pyridiyl)benzaldehyde
  • 4-(2-pyridinyl)phenylaldyhyde
  • (4-(pyridine-2-yl)benzaldehyde
  • 4-PYRIDIN-2-YL-BENZALDEHYDE, 95+%
  • 4-Pyridylenzaldehyde
  • 4-(2-Pyridyl)benzaldehyde,97%
  • 2-(p-ForMylphenyl)pyridine
  • 4-(pyridin-2-yl)-benzaldehyde, 2-(4-forMyl-phenyl)pyridine, 4-(pyrid-2-yl)-benzaldehyde, 4-α-pyridylbenzaldehyde, 4-(pyridin-2-yl)benzaldehyde, 2-(4-forMylphenyl)pyridine, 4-(2'-pyridyl)benzaldehyde
  • Atazanavir iMpurity (Pyridinyl benzaldehyde)
  • 4-(2-Pyridyl)benzaldehyde 97%
  • 2-(4-FORMYLPHENYL)PYRIDINE
  • 4-(PYRIDIN-2-YL)BENZALDEHYDE
  • 4-(2-PYRIDYL)BENZALDEHYDE
  • 4-(2-PYRIDINYL)BENZALDEHYDE
  • AKOS BAR-0490
  • 4-(2-Pyridyl)benzaldehyde&gt
  • 4-(2-Pyridinyl)benzaldehyde ISO 9001：2015 REACH
  • Atazanavir Related Compund E
  • -(2-Pyridyl)benzaldehyde
  • Atazanavir Sulfate EP Impurity B
  • Azanavir EP Impurity B
  • Atazanavir Sulfate Impurity B
  • 4-(2'-Pyridyl)Benzaldehyde
  • Atazanavir EP Impurity 6
  • 127406-56-8
  • 12406-56-8
  • 27406-56-8
  • Heterocyclic Building Blocks
  • Pyridines
  • Building Blocks
  • C9 to C46
  • pharmacetical
  • Aldehydes
  • Phenyls & Phenyl-Het
  • Pyridines
  • Bases & Related Reagents
  • Heterocycles
  • Nucleotides
  • Phenyls & Phenyl-Het
  • C9 to C46
  • Heterocyclic Building Blocks
  • Pyridine