3-Cyanocinnamic acid
- Product Name
- 3-Cyanocinnamic acid
- CAS No.
- 16642-93-6
- Chemical Name
- 3-Cyanocinnamic acid
- Synonyms
- AKOS BAR-2476;3-cyanocinnamicaci;RARECHEM BK HW 0149;3-CYANOCINNAMIC ACID;3-CyanocinnaMic acid, 98%+;3-(3-Cyanophenyl)acrylic acid;3-Cyanocinnamic acid USP/EP/BP;(E)-3-(3-cyanophenyl)acrylic acid;2-PROPENOIC ACID, 3-(3-CYANOPHENYL)-;2-Propenoic acid, 3-(3-cyanophenyl)-, (2E)-
- CBNumber
- CB6361226
- Molecular Formula
- C10H7NO2
- Formula Weight
- 173.17
- MOL File
- 16642-93-6.mol
3-Cyanocinnamic acid Property
- Boiling point:
- 357.9±25.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.20±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2918290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C962520
- Product name
- 3-CyanocinnamicAcid
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC46306
- Product name
- 3-Cyanocinnamic acid
- Packaging
- 5G
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FC46306
- Product name
- 3-Cyanocinnamic acid
- Packaging
- 2g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- FC46306
- Product name
- 3-Cyanocinnamic acid
- Packaging
- 10g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 4937-1-02
- Product name
- 3-Cyanocinnamic acid
- Packaging
- 1g
- Price
- $264
- Updated
- 2021/12/16
3-Cyanocinnamic acid Chemical Properties,Usage,Production
Uses
3-Cyanocinnamic Acid was used to synthesize triazoles with antifungal activities. It was also used to prepare aminocyclohexylethyl-substituted methylsulfonyloxy and methylsulfonyl tetrahydrobenzazepines as dopamine receptor antagonists and antipsychotics.
Synthesis
141-82-2
24964-64-5
16642-93-6
GENERAL METHOD: 3-cyanobenzaldehyde (11a) or 4-cyanobenzaldehyde (11b) (15 mmol) and malonic acid (30 mmol) were dissolved in pyridine (30 mL). Piperidine (3.0 mmol) was added to the solution and the reaction mixture was subsequently heated to reflux at 100 °C for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and acidified by slow addition of 5 M hydrochloric acid solution (25 mL). The precipitated white precipitate was collected by filtration, washed well with water and dried to give the target products (E)-3-cyanocinnamic acid (12a) or (E)-4-cyanocinnamic acid (12b) in 81% and 78% yields, respectively.
References
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 10, p. 5162 - 5174
[2] Journal of the American Chemical Society, 1948, vol. 70, p. 1560
[3] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 9, p. 2021 - 2034
[4] Patent: WO2006/123725, 2006, A1. Location in patent: Page/Page column 40
3-Cyanocinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Cyanocinnamic acid Suppliers
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
- Tel
- --
- Fax
- --
- akos@akosgmbh.de
- Country
- Germany
- ProdList
- 6717
- Advantage
- 72
- Tel
- --
- Fax
- --
- sales@rarechem.de
- Country
- Germany
- ProdList
- 6297
- Advantage
- 38
View Lastest Price from 3-Cyanocinnamic acid manufacturers
- Product
- 3-Cyanocinnamic acid 16642-93-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 25kg
- Release date
- 2019-07-10