ChemicalBook > CAS DataBase List > Z-VDVAD-FMK

Z-VDVAD-FMK

Product Name: Z-VDVAD-FMK
CAS No.: 210344-92-6
Chemical Name: Z-VDVAD-FMK
Synonyms: Z-VDVAD-FMK;CASPASE-2 INHIBITOR I;Z-VD(OME)VAD(OME)-FMK;Z-VDVAD-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FMK;Z-VD(OME)VAD(OME)-FLUOROMETHYLKETONE;Z-VAL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;Z-VAL-ASP(OME)-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE;BENZYLOXYCARBONYL-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
CBNumber: CB6364843
Molecular Formula: C32H46FN5O11
Formula Weight: 695.73
MOL File: Mol file

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Z-VDVAD-FMK Property

storage temp.: −20°C
solubility: DMSO/DMF: 20 mM
form: powder
color: white
biological source: synthetic (organic)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 218744
Product name: Caspase-2 Inhibitor I
Purity: The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging: 250μG
Price: $207
Updated: 2025/07/31

Sigma-Aldrich

Product number: C1605
Product name: Z-Val-Asp(O-Me)-Val-Ala-Asp(O-Me) fluoromethyl ketone
Purity: powder, ≥95% (TLC)
Packaging: 1mg
Price: $547
Updated: 2025/07/31

Sigma-Aldrich

Product number: 218744
Product name: Caspase-2 Inhibitor I
Purity: The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging: 1MG
Price: $577
Updated: 2025/07/31

Chem-Impex

Product number: 32785
Product name: Z-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-fluoromethylketone
Packaging: 1MG
Price: $402.5
Updated: 2021/12/16

ApexBio Technology

Product number: A1922
Product name: Z-VDVAD-FMK
Packaging: 10mg
Price: $500
Updated: 2021/12/16

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Z-VDVAD-FMK Chemical Properties,Usage,Production

Uses

Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][2][3].

Biological Activity

Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells.

Biochem/physiol Actions

A cell-permeable inhibitor of caspase-2, which exhibits competitive and irreversible inhibition.

IC 50

Caspase-2

References

1. j. d. robertson, m. enoksson et al. caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. the journal of biological chemistry. 277, :29803–29809, 2002 2. t. meguro, b. chen et al. caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells, stroke. 2001; 32:561-566. 3. talanian, r. v., quinlan, c., trautz, s., hackett, m. c., mankovich, j. a., banach, d., ghayur, t., brady, k. d., and wong, w. w. (1997). substrate speciﬁcity of caspase family proteases. j. biol. chem. 272, 9677–9682. 4. gamen et al (2000) doxorubicin treatment activates a z-vad-sensitive caspase, which causes dym loss, caspase-9 activity, and apoptosis in jurkat cells. exp.cell res. 258 223.

Z-VDVAD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

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210344-92-6, Z-VDVAD-FMKRelated Search:

CASPASE-6 INHIBITOR I Z-VAD-FMK (2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanamido]-3-hydroxypropanoic acid Z-VAL-ALA-OH Z-VAL-TRP-OH CBZ-L-VALINE METHYL ESTER Z-VAL-VAL-ARG-AMC Z-VAL-VAL-OH Z-VAL-OET Z-VAL-PRO-OH MVPQJUFFTWWKBT-LBDWYMBGSA-N Z-VAL-ILE-OH Z-VAL-PHE-OH CASPASE INHIBITOR III Z-VRPR-FMK (trifluoroacetate salt) N-CBZ-VAL-GLY-ARG P-NITROANILIDE ACETATE SALT Caspase-6 Inhibitor Z-VEID-FMK CASPASE-10 SUBSTRATE AEVD-AFC

BENZYLOXYCARBONYL-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE

CASPASE-2 INHIBITOR I

Z-VAL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE

Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE

Z-VAL-ASP(OME)-VAL-ALA-ASP(OME)-FMK

Z-VAL-ASP(OME)-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE

Z-VDVAD-FLUOROMETHYLKETONE

Z-VDVAD-FMK

Z-VD(OME)VAD(OME)-FLUOROMETHYLKETONE

Z-VD(OME)VAD(OME)-FMK

L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-α-aspartyl-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester

210344-92-6

C32H46N5O11F

C32H46FN5O11

Caspases/Apoptosis

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