1-N-CBZ-3-HYDROXY-PIPERIDINE
Uses- Product Name
- 1-N-CBZ-3-HYDROXY-PIPERIDINE
- CAS No.
- 95798-22-4
- Chemical Name
- 1-N-CBZ-3-HYDROXY-PIPERIDINE
- Synonyms
- BUTTPARK 99\04-58;N-Cbz-3-hydroxypiperidine;1-Cbz-3-hydroxy-piperidine;1-N-CBZ-3-HYDROXY-PIPERIDINE;1-Cbz-3-hydroxy-piperidine - [H12297];1-BENZYLOXYCARBONYL-3-HYDROXYPIPERIDINE;1-N-CBZ-3-HYDROXY-PIPERIDINE ISO 9001：2015 REACH;3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;BENZYL 3-HYDROXYTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;1-Piperidinecarboxylic acid, 3-hydroxy-, phenylMethyl ester
- CBNumber
- CB6365486
- Molecular Formula
- C13H17NO3
- Formula Weight
- 235.28
- MOL File
- 95798-22-4.mol
1-N-CBZ-3-HYDROXY-PIPERIDINE Property
- Boiling point:
- 196 °C
- Density
- 1.220±0.06 g/cm3(Predicted)
- storage temp.
- Store at room temperature
- pka
- 14.72±0.20(Predicted)
- Appearance
- Light yellow to yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B297058
- Product name
- Benzyl3-Hydroxypiperidine-1-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 119286
- Product name
- Benzyl 3-hydroxypiperidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $233
- Updated
- 2021/12/16
- Product number
- W9773
- Product name
- N-Cbz-3-Hydroxypiperidine
- Packaging
- 100g
- Price
- $424
- Updated
- 2021/12/16
- Product number
- CHM0028568
- Product name
- BENZYL 3-HYDROXYTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1437.98
- Updated
- 2021/12/16
- Product number
- CHM0028568
- Product name
- BENZYL 3-HYDROXYTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $2073.23
- Updated
- 2021/12/16
1-N-CBZ-3-HYDROXY-PIPERIDINE Chemical Properties,Usage,Production
Uses
Benzyl 3-hydroxytetrahydropyridinecarboxylate is a carboxylic acid ester organic compound that can be used as a pharmaceutical intermediate.
Synthesis
64051-79-2
501-53-1
95798-22-4
General procedure for the synthesis of N-Benzyloxycarbonyl-3-hydroxypiperidine from 3-hydroxypiperidine hydrochloride and benzyl chloroformate: Na2CO3 (23.10 g, 218 mmol) was added to a solution of THF/H2O (50 mL/50 mL) containing 3-hydroxypiperidine hydrochloride (10.00 g, 73 mmol). Benzyl chloroformate (14.90 g, 87 mmol) was added dropwise at room temperature and the reaction mixture was stirred for 5 hours. After the reaction was completed, the mixture was extracted with EtOAc (100 mL x 3). The organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated. The resulting residue was purified by silica gel column chromatography with EtOAc/petroleum ether (1/100~1/4, v/v) as eluent to afford N-benzyloxycarbonyl-3-hydroxypiperidine (16.50 g, 96%) as a colorless oil. detected by TLC: Rf = 0.65 (silica gel plate, EtOAc/petroleum ether = 1/1, v/v).
References
[1] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 44; 45
[2] Patent: WO2014/68527, 2014, A1. Location in patent: Page/Page column 75; 15
1-N-CBZ-3-HYDROXY-PIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-N-CBZ-3-HYDROXY-PIPERIDINE manufacturers
- Product
- 1-N-CBZ-3-HYDROXY-PIPERIDINE 95798-22-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-26
- Product
- 1-N-CBZ-3-HYDROXY-PIPERIDINE 95798-22-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-08