Uses
ChemicalBook > CAS DataBase List > 1-N-CBZ-3-HYDROXY-PIPERIDINE

1-N-CBZ-3-HYDROXY-PIPERIDINE

Uses
Product Name
1-N-CBZ-3-HYDROXY-PIPERIDINE
CAS No.
95798-22-4
Chemical Name
1-N-CBZ-3-HYDROXY-PIPERIDINE
Synonyms
BUTTPARK 99\04-58;N-Cbz-3-hydroxypiperidine;1-Cbz-3-hydroxy-piperidine;1-N-CBZ-3-HYDROXY-PIPERIDINE;1-Cbz-3-hydroxy-piperidine - [H12297];1-BENZYLOXYCARBONYL-3-HYDROXYPIPERIDINE;1-N-CBZ-3-HYDROXY-PIPERIDINE ISO 9001：2015 REACH;3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;BENZYL 3-HYDROXYTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;1-Piperidinecarboxylic acid, 3-hydroxy-, phenylMethyl ester
CBNumber
CB6365486
Molecular Formula
C13H17NO3
Formula Weight
235.28
MOL File
95798-22-4.mol
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1-N-CBZ-3-HYDROXY-PIPERIDINE Property

Boiling point:
196 °C
Density 
1.220±0.06 g/cm3(Predicted)
storage temp. 
Store at room temperature
pka
14.72±0.20(Predicted)
Appearance
Light yellow to yellow Liquid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
B297058
Product name
Benzyl3-Hydroxypiperidine-1-carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
119286
Product name
Benzyl 3-hydroxypiperidine-1-carboxylate
Purity
95+%
Packaging
5g
Price
$233
Updated
2021/12/16
AK Scientific
Product number
W9773
Product name
N-Cbz-3-Hydroxypiperidine
Packaging
100g
Price
$424
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0028568
Product name
BENZYL 3-HYDROXYTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
Purity
95.00%
Packaging
5G
Price
$1437.98
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0028568
Product name
BENZYL 3-HYDROXYTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
Purity
95.00%
Packaging
10G
Price
$2073.23
Updated
2021/12/16
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1-N-CBZ-3-HYDROXY-PIPERIDINE Chemical Properties,Usage,Production

Uses

Benzyl 3-hydroxytetrahydropyridinecarboxylate is a carboxylic acid ester organic compound that can be used as a pharmaceutical intermediate.

Synthesis

64051-79-2

501-53-1

95798-22-4

General procedure for the synthesis of N-Benzyloxycarbonyl-3-hydroxypiperidine from 3-hydroxypiperidine hydrochloride and benzyl chloroformate: Na2CO3 (23.10 g, 218 mmol) was added to a solution of THF/H2O (50 mL/50 mL) containing 3-hydroxypiperidine hydrochloride (10.00 g, 73 mmol). Benzyl chloroformate (14.90 g, 87 mmol) was added dropwise at room temperature and the reaction mixture was stirred for 5 hours. After the reaction was completed, the mixture was extracted with EtOAc (100 mL x 3). The organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated. The resulting residue was purified by silica gel column chromatography with EtOAc/petroleum ether (1/100~1/4, v/v) as eluent to afford N-benzyloxycarbonyl-3-hydroxypiperidine (16.50 g, 96%) as a colorless oil. detected by TLC: Rf = 0.65 (silica gel plate, EtOAc/petroleum ether = 1/1, v/v).

References

[1] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 44; 45
[2] Patent: WO2014/68527, 2014, A1. Location in patent: Page/Page column 75; 15

1-N-CBZ-3-HYDROXY-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-N-CBZ-3-HYDROXY-PIPERIDINE Suppliers

Belgium 1 China 77 Germany 2 India 1 United Kingdom 3 United States 10 Global 94
Maybridge Chemical Co., Ltd.
Tel
--
Fax
--
Country
Belgium
ProdList
6293
Advantage
73
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View Lastest Price from 1-N-CBZ-3-HYDROXY-PIPERIDINE manufacturers

Dideu Industries Group Limited
Product
1-N-CBZ-3-HYDROXY-PIPERIDINE 95798-22-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-26
Career Henan Chemical Co
Product
1-N-CBZ-3-HYDROXY-PIPERIDINE 95798-22-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-08

95798-22-4, 1-N-CBZ-3-HYDROXY-PIPERIDINERelated Search:

Benzyl formate 3-Hydroxypiperidine (R)-1-N-Cbz-3-hydroxy-piperidine T-BUTYL-3-(N-CBZ-PIPERIDINOXY) ACETATE 3-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 2,3-Bis(acetyloxy)-1-piperidinecarboxylic Acid Phenylmethyl Ester 3-(2,2-DIETHOXY-ETHOXY)-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER benzyl 3-methoxy-4-oxopiperidine-1-carboxylate trans-3,4-Dihydroxypiperidine-1-carboxylic acid benzyl ester METHYL-3-(N-CBZ-PIPERIDINOXY) ACETATE N-Benzyloxycarbonyl-2,3-dihydroxypiperidine 1-N-CBZ-3-HYDROXY-PIPERIDINE METHYL (2S,5R)-1-CBZ-5-HYDROXY-6-METHOXYPIPECOLINATE

  • BENZYL 3-HYDROXYTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
  • BUTTPARK 99\04-58
  • 3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
  • 1-N-CBZ-3-HYDROXY-PIPERIDINE
  • 1-BENZYLOXYCARBONYL-3-HYDROXYPIPERIDINE
  • 1-Cbz-3-hydroxy-piperidine
  • 1-Piperidinecarboxylic acid, 3-hydroxy-, phenylMethyl ester
  • N-Cbz-3-hydroxypiperidine
  • 1-N-CBZ-3-HYDROXY-PIPERIDINE ISO 9001：2015 REACH
  • 1-Cbz-3-hydroxy-piperidine - [H12297]
  • 95798-22-4