Tolfenamic acid
- Product Name
- Tolfenamic acid
- CAS No.
- 13710-19-5
- Chemical Name
- Tolfenamic acid
- Synonyms
- CLOTAM;gea6414;Tolfedine;Tolfenamic;olfenamicaci;Toxamic acid;Tofenamic acid;TOLFENAMIC ACID;TOLEFNAMIC ACID;Tolfenamic acid CRS
- CBNumber
- CB6365693
- Molecular Formula
- C14H12ClNO2
- Formula Weight
- 261.7
- MOL File
- 13710-19-5.mol
Tolfenamic acid Property
- Melting point:
- 210-214°C
- Boiling point:
- 405.4±40.0 °C(Predicted)
- Density
- 1.2037 (rough estimate)
- refractive index
- 1.5270 (estimate)
- storage temp.
- 2-8°C
- solubility
- Practically insoluble in water, soluble in dimethylformamide, sparingly soluble in ethanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.
- pka
- 3.66±0.36(Predicted)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Soluble in water (slightly), acetone (~10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (~10 mg/ml) and ethanol (50 mg/ml).
- Merck
- 14,9513
- InChIKey
- YEZNLOUZAIOMLT-UHFFFAOYSA-N
- CAS DataBase Reference
- 13710-19-5(CAS DataBase Reference)
- EPA Substance Registry System
- Benzoic acid, 2-[(3-chloro-2-methylphenyl)amino]- (13710-19-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 34073
- Product name
- Tolfenamic acid
- Purity
- VETRANAL , analytical standard
- Packaging
- 100mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- PHR1629
- Product name
- Tolfenamic acid
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500mg
- Price
- $82.8
- Updated
- 2022/05/15
- Product number
- C2064
- Product name
- N-(3-Chloro-2-methylphenyl)anthranilic Acid
- Purity
- >97.0%(T)
- Packaging
- 25g
- Price
- $140
- Updated
- 2024/03/01
- Product number
- J61256
- Product name
- Tolfenamic acid, 99+%
- Packaging
- 5g
- Price
- $67.65
- Updated
- 2024/03/01
- Product number
- J61256
- Product name
- Tolfenamic acid, 99+%
- Packaging
- 10g
- Price
- $125.65
- Updated
- 2024/03/01
Tolfenamic acid Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
antiinflammatory, analgesia
Uses
Amidated GRF fragment equipotent to GRF in release of somatotropin from anterior pituitary
Uses
A non steroidal anti-inflammatory agent found to inhibit COX-2 isoenzymes
Uses
Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.
Uses
Non-steroidal anti-inflammatory drugs (NSAIDs).
Definition
ChEBI: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.
General Description
Tolfenamic Acid is an anthranilic acid derivative and a non-steroidal anti-inflammatory drug (NSAID). Its applications in treating pancreatic, esophageal, colorectal and lung cancer is being investigated.
Biochem/physiol Actions
Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor.
Clinical Use
NSAID:
Treatment of migraine
Synthesis
Tolfenamic acid is obtained by
condensation of 2-chlorobenzoic acid with 3-
chloro-2-methyl-phenylamine using CuBr2 in
diethylenglycol dimethyl ether .
Veterinary Drugs and Treatments
Tolfenamic acid may be useful for the treatment of acute or chronic pain and/or inflammation in dogs and acute pain/inflammation in cats. In Europe, it is also approved for use in cattle.
Drug interactions
Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists:
antagonism of hypotensive effect; increased risk of
nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more
NSAIDs, including aspirin (increased side effects);
avoid with ketorolac (increased risk of side effects
and haemorrhage).
Antibacterials: possibly increased risk of convulsions
with quinolones.
Anticoagulants: effects of coumarins and
phenindione enhanced; possibly increased risk of
bleeding with heparins, dabigatran and edoxaban.
Antidepressants: increased risk of bleeding with
SSRIs and venlafaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin
concentration.
Antivirals: increased risk of haematological toxicity
with zidovudine; concentration possibly increased by
ritonavir.
Ciclosporin: may potentiate nephrotoxicity.
Cytotoxics: reduced excretion of methotrexate;
increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity;
antagonism of diuretic effect; hyperkalaemia with
potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity
Metabolism
Tolfenamic acid is metabolised in the liver; the metabolites and unchanged drug are conjugated with glucuronic acid. About 90
% of an ingested dose is excreted in the urine and the remainder in the faeces.
Tolfenamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tolfenamic acid manufacturers
- Product
- Tolfenamic acid 13710-19-5
- Price
- US $200.00-170.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20Tons
- Release date
- 2023-10-09
- Product
- Tolfenamic acid 13710-19-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- Tolfenamic acid 13710-19-5
- Price
- US $40.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-15