4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide

Product Name: 4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide
CAS No.: 1855006-12-0
Chemical Name: 4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide
Synonyms: Regorafenib Dipyrimidine;Regorafenib Impurities69;Regorafenib Impurities11;Regorafenib Impurities04;Azilsartan medoxomil impurity263;1-chloro-3-isocyanato-2-(trifluoromethyl)benzene;4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide;4-(3-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide formate;4-[3-Fluoro-4-[[2-(methylcarbamoyl)pyridin-4- yl]amino]phenoxy]-N-methylpyridine-2-carboxamide;2-Pyridinecarboxamide, 4-[3-fluoro-4-[[2-[(methylamino)carbonyl]-4-pyridinyl]amino]phenoxy]-N-methyl-
CBNumber: CB63660630
Molecular Formula: C20H18FN5O3
Formula Weight: 395.39
MOL File: 1855006-12-0.mol

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4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide Property

Boiling point:: 631.8±55.0 °C(Predicted)
Density: 1.329±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 13.92±0.46(Predicted)
InChIKey: USLJNRHZMUHXEP-UHFFFAOYSA-N
SMILES: Fc1c(ccc(c1)Oc3cc(ncc3)C(=O)NC)Nc2cc(ncc2)C(=O)NC

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0002091
Product name: Regorafenib impurity C
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 10 mg
Price: $127
Updated: 2026/04/30

ChemScene

Product number: CS-M2814
Product name: 4-(3-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide
Purity: 98.60%
Packaging: 5mg
Price: $1500
Updated: 2021/12/16

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4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide Chemical Properties,Usage,Production

Uses

Regorafenib Dipyrimidine is an impurity of Regorafenib(R143000); which inhibits PDGFR tyrosine kinase with IC50=83nM. Also useful for the treatment of inflammation and as an anti-proliferative agent.

4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide Suppliers

China 34 India 1 Global 35

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1855006-12-0, 4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamideRelated Search:

2-Pyridinecarboxamide, 4-[2-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl- N-Desmethyl Regorafenib N-Oxide (M5 Metabolite) Regorafenib Impurity 13 Regorafenib Impurity 9 Regorafenib Impurity 10 N-Desmethyl Regorafenib 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE 4-(4-(3-(4-chloro-3-(trifluoroMethyl)phenyl)ureido)-3-fluorophenoxy)-2-(MethylcarbaMoyl)pyridine 1-oxide Regorafenib Impurity 6 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]phenoxy]-N-methyl- Regorafenib Impurity 17 4-(4-amino-3-(4-amino-3-(4-amino-3-fluorophenoxy)phenoxy)phenoxy)-N-methylpicolinamide INDEX NAME NOT YET ASSIGNED Regorafenib Impurity 16

4-[2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yl]oxyanilino]-N-methylpyridine-2-carboxamide

2-Pyridinecarboxamide, 4-[3-fluoro-4-[[2-[(methylamino)carbonyl]-4-pyridinyl]amino]phenoxy]-N-methyl-

Regorafenib Dipyrimidine

4-(3-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide formate

Regorafenib Impurities69

Azilsartan medoxomil impurity263

Regorafenib Impurities04

Regorafenib Impurities11

Regorafenib Impurity 4Q: What is Regorafenib Impurity 4 Q: What is the CAS Number of Regorafenib Impurity 4 Q: What is the storage condition of Regorafenib Impurity 4 Q: What are the applications of Regorafenib Impurity 4

4-[3-Fluoro-4-[[2-(methylcarbamoyl)pyridin-4- yl]amino]phenoxy]-N-methylpyridine-2-carboxamide

1-chloro-3-isocyanato-2-(trifluoromethyl)benzene

1855006-12-0