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Balsalazide disodium

Product Name
Balsalazide disodium
CAS No.
213594-60-6
Chemical Name
Balsalazide disodium
Synonyms
BALSALAZIDE SODIUM;BALSALZIDE DISODIUM;Balsalazide disodium;BALSALAZIDE SODIUM 98+%;Balsalazide disodium salt hydrate;5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic acid disodium salt hydrate;(3E)-3-[[4-(2-carboxylatoethylcarbamoyl)phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylate;Disodium (3E)-3-[[4-[(3-oxido-3-oxopropyl)carbamoyl]phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylate
CBNumber
CB6367031
Molecular Formula
C17H13N3Na2O6
Formula Weight
401.28
MOL File
213594-60-6.mol
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Balsalazide disodium Property

storage temp. 
2-8°C
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Safety

WGK Germany 
nwg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B5438
Product name
Balsalazide disodium salt hydrate
Purity
≥99% (HPLC)
Packaging
25mg
Price
$297
Updated
2023/06/20
TRC
Product number
B116323
Product name
BalsalazideDisodium
Packaging
1000mg
Price
$1850
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB164189
Product name
Balsalazide disodium
Packaging
10g
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB164189
Product name
Balsalazide disodium
Packaging
5G
Price
$120
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000414
Product name
BALSALAZIDE DISODIUM
Purity
95.00%
Packaging
1G
Price
$168
Updated
2021/12/16
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Balsalazide disodium Chemical Properties,Usage,Production

Originator

Colazal,Salix Pharmaceuticals,,USA

Manufacturing Process

125 g finely powdered 4-nitrobenzoyl chloride were added portionwise, while stirring, to a solution of 70 g β-alanine in 500 ml water containing 65 g sodium hydroxide and cooled to 5°C. The reaction mixture was stirred for 3 hours and then added to a mixture of ice and hydrochloric acid. The precipitate obtained was filtered off, washed with water and dried by suction. After crystallisation of the dried product from hot acetone, there were obtained 130 g 4-nitrobenzoyl-β-alanine, M.P. 164°-166°C.
A suspension of 15 g finely powdered 4-nitrobenzoyl-β-alanine in 200 ml ethanol was stirred in an atmosphere of hydrogen in the presence of 1 g of palladium-charcoal (5%), while cooling gently. When the absorption of hydrogen had ceased, the reaction mixture was filtered and the filtrate concentrated to a small volume. Upon adding diethyl ether and cooling 4- aminobenzoyl-β-alanine was obtained. The yield was 11.5 g, M.P. 156°-158°C.
8.8 g 4-aminobenzoyl-β-alanine were triturated with 12 ml hydrochloric acid and the paste obtained was dissolved in 100 ml water. The solution was cooled to -5°C and a solution of 3 g sodium nitrite in 20 ml water, cooled to 0°C, was added dropwise, while stirring. The diazotised solution was left for 1 hour at 0°C and was then added dropwise at -5°C to a solution of 6 g salicylic acid in 70 ml water containing 3.6 g sodium hydroxide and 7 g sodium carbonate. The final reaction mixture was adjusted to a pH of about 8, stirred for 2 to 3 hours and added to a mixture of dilute hydrochloric acid and ice. The precipitate obtained was filtered off, washed with water and suction dried. Crystallisation from hot ethanol gave 11.9 g 5-[(2-carboxy-ethylcarbamoyl)- phenylazo]-2-hydroxy-benzoic acid, M.P. 254°-255°C.
10.7 g of the free acid were dissolved in 300 ml warm ethanol and treated with a solution of 2.4 g sodium hydroxide in 25 ml ethanol. The precipitate obtained was filtered off, washed with ethanol and diethyl ether and dried in a vacuum at 50°C to give 11.5 g of the disodium salt of 5-[(2-carboxyethylcarbamoyl)- phenylazo]-2-hydroxy-benzoic acid, M.P. >350°C.

Therapeutic Function

Antiinflammatory

Balsalazide disodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Balsalazide disodium Suppliers

Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25363
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
info@afinechem.com
Country
China
ProdList
15396
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49391
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44843
Advantage
58
Joyman BIOTECH (Lianyungang) Co., Ltd.
Tel
0518-85817797 18661269107
Email
info@joy-man.com
Country
China
ProdList
41
Advantage
58

213594-60-6, Balsalazide disodiumRelated Search:


  • BALSALZIDE DISODIUM
  • BALSALAZIDE SODIUM
  • BALSALAZIDE SODIUM 98+%
  • Disodium (3E)-3-[[4-[(3-oxido-3-oxopropyl)carbamoyl]phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylate
  • 5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic acid disodium salt hydrate
  • Balsalazide disodium salt hydrate
  • Balsalazide disodium
  • (3E)-3-[[4-(2-carboxylatoethylcarbamoyl)phenyl]hydrazinylidene]-6-oxocyclohexa-1,4-diene-1-carboxylate
  • 213594-60-6
  • C17H15N3O62Na