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Sodium phosphate dibasic dodecahydrate

Product Name
Sodium phosphate dibasic dodecahydrate
CAS No.
10039-32-4
Chemical Name
Sodium phosphate dibasic dodecahydrate
Synonyms
dodecahydrate;lisnuanerqingna;DISODIUM PHOSPHATE (DSP);SODIUM PFAT 2BAS 12HYD XTL;DISODIUM HYDROGEN PHOSPHATE;di-Sodiumhydrogenphosphate,d;SodiumPhosphateDibasic12H2OAr;SodiumPhosphateDibasic12H2OBp;SodiumPhosphateDibasic12H2OIp;SODIUM MONOHYDROGEN PHOSPHATE
CBNumber
CB1324215
Molecular Formula
H25Na2O16P
Formula Weight
358.14
MOL File
10039-32-4.mol
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Sodium phosphate dibasic dodecahydrate Property

Melting point:
35 °C
Density 
1,52 g/cm3
storage temp. 
Store at +15°C to +25°C.
solubility 
H2O: 0.1 M at 20 °C, clear, colorless
form 
Crystals
color 
White
Odor
Odorless
PH
9.0-9.3 (25℃, 50mg/mL in H2O)
PH Range
8.4 - 9.6 at 36 g/l at 25 °C
Water Solubility 
218 g/L (20 ºC)
λmax
λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
InChIKey
DGLRDKLJZLEJCY-UHFFFAOYSA-L
CAS DataBase Reference
10039-32-4(CAS DataBase Reference)
EPA Substance Registry System
Disodium phosphate dodecahydrate (10039-32-4)
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Safety

Safety Statements 
24/25
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
1
RTECS 
TC5725000
HS Code 
28352200
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1.06579
Product name
di-Sodium hydrogen phosphate dodecahydrate
Purity
for analysis EMSURE? ISO,Reag. Ph Eur
Packaging
500 g
Price
$43.66
Updated
2021/12/16
Sigma-Aldrich
Product number
1.06573
Product name
di-Sodium hydrogen phosphate dodecahydrate
Purity
cryst., Emprove? Essential, Ph. Eur., BP, ChP, JP, USP
Packaging
1 kg
Price
$48.2
Updated
2021/12/16
Sigma-Aldrich
Product number
04273
Product name
Sodium phosphate dibasic dodecahydrate
Purity
meets analytical specification of Ph. Eur., BP, E339, 98.5-101% (calc. to the dried substance)
Packaging
1kg
Price
$56.6
Updated
2021/12/16
Sigma-Aldrich
Product number
1.06585
Product name
di-Sodium hydrogen phosphate
Purity
anhydrous EMPROVE? ESSENTIAL Ph Eur,BP,USP,JPE,E 339
Packaging
1 kg
Price
$66.4
Updated
2021/12/16
Sigma-Aldrich
Product number
1.06579
Product name
di-Sodium hydrogen phosphate dodecahydrate
Purity
for analysis EMSURE? ISO,Reag. Ph Eur
Packaging
1 kg
Price
$66.88
Updated
2021/12/16
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Sodium phosphate dibasic dodecahydrate Chemical Properties,Usage,Production

Chemical Properties

white crystals

Chemical Properties

The USP 32 states that dibasic sodium phosphate is dried or contains, 1, 2, 7, or 12 molecules of water of hydration. Anhydrous dibasic sodium phosphate occurs as a white powder. The dihydrate occurs as white or almost white, odorless crystals.
The heptahydrate occurs as colorless crystals or as a white granular or caked salt that effloresces in warm, dry air. The dodecahydrate occurs as strongly efflorescent, colorless or transparent crystals.

Uses

Laxative.

Uses

Sodium Phosphate Dibasic Dodecahydrate is used in method for preparing self-supporting membrane.

Production Methods

Either bone phosphate (bone ash), obtained by heating bones to whiteness, or the mineral phosphorite is used as a source of tribasic calcium phosphate, which is the starting material in the industrial production of dibasic sodium phosphate.
Tribasic calcium phosphate is finely ground and digested with sulfuric acid. This mixture is then leached with hot water and neutralized with sodium carbonate, and dibasic sodium phosphate is crystallized from the filtrate.

Definition

ChEBI: A hydrate that is the dodecahydrate form of disodium hydrogenphosphate

General Description

Sodium phosphate is a colorless crystalline sodium salt. It is widely used as a buffer in molecular biology, biochemistry, and chromatographic studies. It exists in three forms: monobasic (NaH2PO4), dibasic (Na2HPO4), and tribasic (Na3PO4). Monobasic and dibasic forms in varying ratios are commonly used to compose the neutral sodium phosphate buffer solution.

Pharmaceutical Applications

Dibasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, dibasic sodium phosphate is used as a mild laxative and in the treatment of hypophosphatemia.
Dibasic sodium phosphate is also used in food products; for example as an emulsifier in processed cheese.

Safety

Dibasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations. Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia (phosphate deficiency) virtually unknown except for certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces.
Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally. Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of dibasic sodium phosphate as an excipient in oral formulations. However, the level of dibasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, oral): 17 g/kg

storage

The anhydrous form of dibasic sodium phosphate is hygroscopic. When heated to 40℃, the dodecahydrate fuses; at 100℃ it loses its water of crystallization; and at a dull-red heat (about 240℃) it is converted into the pyrophosphate, Na4P2O7. Aqueous solutions of dibasic sodium phosphate are stable and may be sterilized by autoclaving.
The bulk material should be stored in an airtight container, in a cool, dry place.

Incompatibilities

Dibasic sodium phosphate is incompatible with alkaloids, antipyrine, chloral hydrate, lead acetate, pyrogallol, resorcinol and calcium gluconate, and ciprofloxacin. Interaction between calcium and phosphate, leading to the formation of insoluble calcium-phosphate precipitates, is possible in parenteral admixtures.

Regulatory Status

GRAS listed. Accepted in Europe for use as a food additive. Included in the FDA Inactive Ingredients Database (injections; infusions; nasal, ophthalmic, oral, otic, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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Sodium phosphate dibasic dodecahydrate Suppliers

Ningbo Yinzhou Chaoyang Shengda Chemical Plant
Tel
0574-88463601-
Email
18069051118@126.com
Country
China
ProdList
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-62063333-1
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
Advantage
65
VWR(Shanghai) Co., Ltd
Tel
400-821-8006
Fax
+86-21-58558801
Email
info_china@vwr.com
Country
China
ProdList
3044
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Nanjing chemical reagent co. LTD
Fax
025-85312034
Email
3511588639@qq.com
Country
China
ProdList
3507
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58
Xuzhou Sunyu Chemical Technology Co., Ltd.
Tel
0516-82282337-
Fax
0516-82282337
Email
luqs@songyucn.com
Country
China
ProdList
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J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-021-61259100
Fax
86-21-61259102
Email
int02@meryer.com
Country
China
ProdList
40264
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Beijing dtftchem Technology Co., Ltd.
Tel
13651141086; 86(10)60275028、60275820
Fax
86 (10) 60270825
Email
dtftchem@sina.com
Country
China
ProdList
3392
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BeiJing Hwrk Chemicals Limted
Tel
0757-86329057- ;021-51691807-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com;peter.shi@hwrkchemical.com
Country
China
ProdList
17295
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Beijing Ouhe Technology Co., Ltd
Tel
010-82967028-
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12270
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60
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View Lastest Price from Sodium phosphate dibasic dodecahydrate manufacturers

Hebei Dongdu Import and Export Co. LTD
Product
Disodium Phosphate 10039-32-4
Price
US $0.60/Kg/Bag
Min. Order
1KG
Purity
98%
Supply Ability
800tons/month
Release date
2020-11-27
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Sodium phosphate dibasic dodecahydrate 10039-32-4
Price
US $0.00/KG
Min. Order
1KG
Purity
97.0%
Supply Ability
20tons/month
Release date
2021-07-19
Shijiazhuang tongyang Import and Export Co., LTD
Product
Sodium phosphate dibasic dodecahydrate 10039-32-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99
Supply Ability
100 mt
Release date
2021-08-13

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