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Disodium hydrogen phosphate dihydrate

Product Name
Disodium hydrogen phosphate dihydrate
CAS No.
10028-24-7
Chemical Name
Disodium hydrogen phosphate dihydrate
Synonyms
DISODIUM PHOSPHATE;DISODIUM HYDROGEN PHOSPHATE;DSP;DIBASIC SODIUM PHOSPHATE;DSPA;BUFFER SOLUTION;SODIUM PHOSPHATE, DIBASIC;Sodium phosphate dibasic dihydrate;SODIUM MONOHYDROGEN PHOSPHATE;FEMA 2398
CBNumber
CB4852564
Molecular Formula
2Na.HO4P.2H2O
Formula Weight
177.99
MOL File
10028-24-7.mol
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Disodium hydrogen phosphate dihydrate Property

Melting point:
92,5°C
Density 
1.064 g/mL at 20 °C
vapor density 
4.9 (vs air)
storage temp. 
Store at +5°C to +30°C.
solubility 
H2O: 0.5 M at 20 °C, clear, colorless
form 
powder
color 
White
Odor
Odorless
PH Range
9.1
PH
8.9-9.2 (25℃, 0.5M in H2O)
Water Solubility 
Soluble in water
λmax
λ: 260 nm Amax: 0.03
λ: 280 nm Amax: 0.03
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
KDQPSPMLNJTZAL-UHFFFAOYSA-L
CAS DataBase Reference
10028-24-7(CAS DataBase Reference)
EPA Substance Registry System
Disodium phosphate dihydrate (10028-24-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25-22
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
WC4500000
3
HS Code 
28352200
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1.37036
Product name
di-Sodium hydrogen phosphate dihydrate
Purity
EMPROVE? EXPERT, Ph. Eur., BP, USP
Packaging
1KG
Price
$81
Updated
2024/03/01
Sigma-Aldrich
Product number
1.37036
Product name
di-Sodium hydrogen phosphate dihydrate
Purity
EMPROVE? EXPERT Ph Eur,BP,USP
Packaging
5kg
Price
$230
Updated
2024/03/01
Sigma-Aldrich
Product number
1.37036
Product name
di-Sodium hydrogen phosphate dihydrate
Purity
EMPROVE? EXPERT Ph Eur,BP,USP
Packaging
12kg
Price
$621
Updated
2024/03/01
Sigma-Aldrich
Product number
1.37036
Product name
di-Sodium hydrogen phosphate dihydrate
Purity
EMPROVE? EXPERT Ph Eur,BP,USP
Packaging
25kg
Price
$682
Updated
2024/03/01
Sigma-Aldrich
Product number
1.06580
Product name
di-Sodium hydrogen phosphate dihydrate
Purity
for analysis EMSURE?
Packaging
500g
Price
$104
Updated
2024/03/01
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Disodium hydrogen phosphate dihydrate Chemical Properties,Usage,Production

Chemical Properties

solid

Chemical Properties

The USP 32 states that dibasic sodium phosphate is dried or contains, 1, 2, 7, or 12 molecules of water of hydration. Anhydrous dibasic sodium phosphate occurs as a white powder. The dihydrate occurs as white or almost white, odorless crystals.
The heptahydrate occurs as colorless crystals or as a white granular or caked salt that effloresces in warm, dry air. The dodecahydrate occurs as strongly efflorescent, colorless or transparent crystals.

Uses

Laxative.

Uses

Sodium Phosphate Dibasic Dihydrate is a treatment of Ischemic stroke with aptamers targeting toll-like receptor 4 (TLR-4).

Uses

Sodium phosphate dibasic dihydrate has been used for isolating DNA and RNA from bacterial samples of human gastrointestinal (GI) tract.

Production Methods

Either bone phosphate (bone ash), obtained by heating bones to whiteness, or the mineral phosphorite is used as a source of tribasic calcium phosphate, which is the starting material in the industrial production of dibasic sodium phosphate.
Tribasic calcium phosphate is finely ground and digested with sulfuric acid. This mixture is then leached with hot water and neutralized with sodium carbonate, and dibasic sodium phosphate is crystallized from the filtrate.

Definition

ChEBI: A hydrate that is the dihydrate form of disodium hydrogenphosphate

Pharmaceutical Applications

Dibasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, dibasic sodium phosphate is used as a mild laxative and in the treatment of hypophosphatemia.
Dibasic sodium phosphate is also used in food products; for example as an emulsifier in processed cheese.

Biochem/physiol Actions

Sodium phosphate dibasic dehydrate is an important component of running buffer of denaturing gel electrophoresis.

Safety

Dibasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations. Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia (phosphate deficiency) virtually unknown except for certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces.
Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally. Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of dibasic sodium phosphate as an excipient in oral formulations. However, the level of dibasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, oral): 17 g/kg

storage

The anhydrous form of dibasic sodium phosphate is hygroscopic. When heated to 40℃, the dodecahydrate fuses; at 100℃ it loses its water of crystallization; and at a dull-red heat (about 240℃) it is converted into the pyrophosphate, Na4P2O7. Aqueous solutions of dibasic sodium phosphate are stable and may be sterilized by autoclaving.
The bulk material should be stored in an airtight container, in a cool, dry place.

Incompatibilities

Dibasic sodium phosphate is incompatible with alkaloids, antipyrine, chloral hydrate, lead acetate, pyrogallol, resorcinol and calcium gluconate, and ciprofloxacin. Interaction between calcium and phosphate, leading to the formation of insoluble calcium-phosphate precipitates, is possible in parenteral admixtures.

Regulatory Status

GRAS listed. Accepted in Europe for use as a food additive. Included in the FDA Inactive Ingredients Database (injections; infusions; nasal, ophthalmic, oral, otic, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Disodium hydrogen phosphate dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Disodium hydrogen phosphate dihydrate Suppliers

Lianyungang Kexin Chemical Co., Ltd.
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View Lastest Price from Disodium hydrogen phosphate dihydrate manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Disodium hydrogen phosphate dihydrate 10028-24-7
Price
US $35.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
30 tons
Release date
2023-10-13
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Disodium hydrogen phosphate dihydrate 10028-24-7
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-16
Shaanxi Haibo Biotechnology Co., Ltd
Product
Disodium hydrogen phosphate dihydrate 10028-24-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-08

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