4-BENZYLOXY-3-METHOXYPHENYLACETONITRILE
- Product Name
- 4-BENZYLOXY-3-METHOXYPHENYLACETONITRILE
- CAS No.
- 1700-29-4
- Chemical Name
- 4-BENZYLOXY-3-METHOXYPHENYLACETONITRILE
- Synonyms
- 4-Benzyloxy-3-methoxybenzyl cyanide;4-BENZYLOXY-3-METHOXYPHENYLACETONITRILE;4-(Benzyloxy)-3-methoxyphenylacetonitrile 98%;2-(4-(Benzyloxy)-3-Methoxyphenyl)acetonitrile;3-Methoxy-4-(Phenylmethoxy)-Benzeneacetonitrile;2-(3-methoxy-4-phenylmethoxyphenyl)acetonitrile;Benzeneacetonitrile, 3-methoxy-4-(phenylmethoxy)-;4-Benzyloxy-3-methoxybenzyl cyanide, 2-(Benzyloxy)-5-(cyanomethyl)anisole
- CBNumber
- CB6367314
- Molecular Formula
- C16H15NO2
- Formula Weight
- 253.3
- MOL File
- 1700-29-4.mol
4-BENZYLOXY-3-METHOXYPHENYLACETONITRILE Property
- Melting point:
- 68-70°C
- Boiling point:
- 195°C 1mm
- Density
- 1.129±0.06 g/cm3(Predicted)
- Flash point:
- 195°C/1mm
- storage temp.
- Sealed in dry,Room Temperature
- BRN
- 2702492
- CAS DataBase Reference
- 1700-29-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P321Specific treatment (see … on this label).
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B286888
- Product name
- 4-Benzyloxy-3-methoxyphenylacetonitrile
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B286888
- Product name
- 4-Benzyloxy-3-methoxyphenylacetonitrile
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR7895
- Product name
- 4-(Benzyloxy)-3-methoxyphenylacetonitrile
- Purity
- 98%
- Packaging
- 250mg
- Price
- $18
- Updated
- 2021/12/16
- Product number
- 4637-1-N8
- Product name
- 4-Benzyloxy-3-methoxyphenylacetonitrile
- Packaging
- 250mg
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 018224
- Product name
- 4-Benzyloxy-3-methoxyphenylacetonitrile
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
4-BENZYLOXY-3-METHOXYPHENYLACETONITRILE Chemical Properties,Usage,Production
Synthesis
4468-59-1
100-39-0
1700-29-4
4-Phenylmethoxy-3-methoxyphenylacetonitrile was prepared by reaction of 4-hydroxy-3-methoxyphenylacetonitrile (1.08 g, 6.60 mmol, 1.0 eq.) and benzyl bromide (1.24 g, 7.26 mmol, 1.1 eq.) in acetone (14 mL) according to the modified method of Imbri et al. First, K2CO3 (1.10 g, 7.92 mmol, 1.2 eq.) was added to the acetone solution of 4-hydroxy-3-methoxyphenylacetonitrile and the suspension was stirred for 10 min. Subsequently, benzyl bromide was added slowly dropwise via syringe. The reaction mixture was heated to reflux for 4 hours. Upon completion of the reaction, the suspension was separated by filtration and the precipitated solid was washed with acetone (10 mL). The filtrate was concentrated under reduced pressure and diluted with dichloromethane (DCM, 50 mL). The organic layer was washed sequentially with 2N NaOH (30 mL) and brine (30 mL) and then dried with Na2SO4. Finally, the solvent was removed by vacuum to afford the target product, 4-phenylmethoxy-3-methoxyphenylacetonitrile, as a yellow solid (1.67 g, 6.59 mmol, quantitative yield). The thin layer chromatography (TLC) Rf value of the product was 0.43 (cyclohexane/ethyl acetate, 2:1). The melting point was 65-66 °C. Nuclear magnetic resonance hydrogen (1H NMR, 400 MHz, CDCl3) and carbon (13C NMR, 100.6 MHz, CDCl3) data were consistent with the literature reports, confirming the structure of the product.
References
[1] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 22, p. 6137 - 6148
[2] Chemistry - A European Journal, 2013, vol. 19, # 45, p. 15080 - 15083
4-BENZYLOXY-3-METHOXYPHENYLACETONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
4-BENZYLOXY-3-METHOXYPHENYLACETONITRILE Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
- Tel
- --
- Fax
- --
- info@abcr.de
- Country
- Germany
- ProdList
- 6831
- Advantage
- 75
View Lastest Price from 4-BENZYLOXY-3-METHOXYPHENYLACETONITRILE manufacturers
- Product
- 2-(4-(benzyloxy)-3-methoxyphenyl) acetonitrile 1700-29-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25