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ISOTETRANDRINE

Product Name
ISOTETRANDRINE
CAS No.
477-57-6
Chemical Name
ISOTETRANDRINE
Synonyms
NSC 97338;isosinomenina;ISOTETRANDRINE;isosinomeninea;1-isotetrandrine;O-METHYLBERBAMINE;(r,s)-tetrandrine;1-Isotetrandrine(8CI);o,o’-dimethylobamegine;BERBAMINE METHYL ETHER
CBNumber
CB6376880
Molecular Formula
C38H42N2O6
Formula Weight
622.76
MOL File
477-57-6.mol
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ISOTETRANDRINE Property

Melting point:
180-182℃
Boiling point:
710.5±60.0 °C(Predicted)
Density 
1.172
RTECS 
NX7285000
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Off-white solid.
pka
7.70±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J67081
Product name
Isotetrandrine, 98%
Packaging
1mg
Price
$120
Updated
2023/06/20
TRC
Product number
I918015
Product name
Isotetrandrine
Packaging
50mg
Price
$685
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001324
Product name
ISOTETRANDRINE
Purity
98.00%
Packaging
25MG
Price
$1270.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001324
Product name
ISOTETRANDRINE
Purity
98.00%
Packaging
1MG
Price
$187.95
Updated
2021/12/16
Arctom
Product number
AS325629
Product name
Isotetrandrine
Packaging
5mg
Price
$226
Updated
2021/12/16
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ISOTETRANDRINE Chemical Properties,Usage,Production

Description

A bisbenzylisoquinoline alkaloid, shown to be identical with berbamine methyl ether, this base occurs in A therosperrna rnoschaturn, Berberis japonica and Stephania cephalantha. It is dextrorotatory with [α]17D + 146° or[α]20D + 150.7° (c 0.85, CHC13). When recrystallized from MeOH it forms colourless crystals and furnishes a crystalline dimethiodide, m.p. 242°C. Four methoxyl groups and two methylimino groups are present.

Uses

Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2.

target

IL Receptor | NF-kB | MAPK | Nrf2 | HO-1 | JNK

References

Kondo et al., J. Pharrn. Soc., Japan, 58,920 (1938)
Tomita, Fujita, Morai., ibid, 71,226,301 (1951)
Bick, Clezy, Crow., Austral. J. Chern., 9, III (1956)
Synthesis:
Inubushi et ai., Tetrahedron Lett., 3399 (1968)

ISOTETRANDRINE Preparation Products And Raw materials

Raw materials

Preparation Products

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ISOTETRANDRINE Suppliers

China 69 Germany 1 Switzerland 1 United Kingdom 7 United States 16 USA 1 Global 95
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View Lastest Price from ISOTETRANDRINE manufacturers

Career Henan Chemical Co
Product
ISOTETRANDRINE 477-57-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons
Release date
2020-03-12

477-57-6, ISOTETRANDRINERelated Search:

Demethyl tetrandrine N-Methyl-3-phenoxybenzylamine 2,3,4-Trimethoxybenzylamine (R)-(+)-Tetrahydropapaverine SALSOLIDINE (R)-1-(3,4-Dimethoxyphenyl)ethylamine 3-PHENOXYPHENETHYLAMINE N-METHYL-N-(2-PHENOXYBENZYL)AMINE 97+% (+/-)-Tetrahydropapaverine (S)-1-(3,4-Dimethoxyphenyl)ethylamine MAGNOLINE 2,2'-DIHYDROXYDIPHENYL ETHER BERBAMINE DL-LAUDANOSINE ISOTETRANDRINE CHEMBRDG-BB 5209105 3,4,5-TRIMETHOXYPHENETHYLAMINE, HYDROCHLORIDE Phenol, 4-(1-aminoethyl)-2-methoxy-, (R)- (9CI)

  • 1-isotetrandrine
  • 6,6’,7,12-tetramethoxy-2,2’-dimethyl-berbama
  • isosinomenina
  • isosinomeninea
  • o,o’-dimethylobamegine
  • o,o’-dimethylstepholine
  • O-METHYLBERBAMINE
  • BERBAMINE METHYL ETHER
  • ISOTETRANDRINE
  • (r,s)-tetrandrine
  • (4aS,16aR)-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline
  • NSC 97338
  • 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-, (4aS,16aR)-
  • 1-Isotetrandrine(8CI)
  • 477-57-6
  • C38H42N2O6
  • Alkaloids