3-Bromobenzyl bromide
- Product Name
- 3-Bromobenzyl bromide
- CAS No.
- 823-78-9
- Chemical Name
- 3-Bromobenzyl bromide
- Synonyms
- m-Bromobenzyl;3-BromobenzyL;α,3-dibromotoluene;à,3-dibromotoluene;3-Bromoben bromide;3-BroMobenl broMide;3-Brombenzyl bromide;3-Bromobenzyl bromid;BroMobenzyl chloride;Toluene,m,α-dibromo-
- CBNumber
- CB6381257
- Molecular Formula
- C7H6Br2
- Formula Weight
- 249.93
- MOL File
- 823-78-9.mol
3-Bromobenzyl bromide Property
- Melting point:
- 39-41 °C(lit.)
- Boiling point:
- 130 °C12 mm Hg
- Density
- 1,56 g/cm3
- refractive index
- 1.6066 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- Adhering Crystals or Crystalline Powder
- color
- White
- Water Solubility
- Insoluble in water.
- BRN
- 2078683
- InChI
- InChI=1S/C7H6Br2/c8-5-6-2-1-3-7(9)4-6/h1-4H,5H2
- InChIKey
- ZPCJPJQUVRIILS-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC=CC(CBr)=C1
- CAS DataBase Reference
- 823-78-9(CAS DataBase Reference)
- EPA Substance Registry System
- Benzene, 1-bromo-3-(bromomethyl)- (823-78-9)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-37
- Safety Statements
- 26-36/37/39-45-25
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- F
- 19
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29036990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 187062
- Product name
- 3-Bromobenzyl bromide
- Purity
- 99%
- Packaging
- 5g
- Price
- $43.5
- Updated
- 2025/07/31
- Product number
- 187062
- Product name
- 3-Bromobenzyl bromide
- Purity
- 99%
- Packaging
- 25g
- Price
- $60.1
- Updated
- 2025/07/31
- Product number
- B1570
- Product name
- 3-Bromobenzyl Bromide
- Packaging
- 5G
- Price
- $19
- Updated
- 2025/07/31
- Product number
- B1570
- Product name
- 3-Bromobenzyl Bromide
- Packaging
- 25G
- Price
- $40
- Updated
- 2025/07/31
- Product number
- B680508
- Product name
- 3-Bromobenzyl bromide
- Packaging
- 2.5g
- Price
- $60
- Updated
- 2021/12/16
3-Bromobenzyl bromide Chemical Properties,Usage,Production
Chemical Properties
White to yellow solid
Uses
3-Bromobenzyl bromide was used in the synthesis of, 1,7-di(3-bromobenzyl)cyclen and substituted 8-arylquinoline, phosphodiesterase 4 (PDE4) inhibitors.
Uses
3-Bromobenzyl bromide was used in the synthesis of:
- 1,7-di(3-bromobenzyl)cyclen
- substituted 8-arylquinoline, phosphodiesterase 4 (PDE4) inhibitors
General Description
3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.
Synthesis
591-17-3
823-78-9
General procedure for the synthesis of 3-bromobenzyl bromide from 3-bromomethylbenzene: To a mixture of N-bromosuccinimide (NXS) and substrate (1 or 6) in acetonitrile (CH3CN), silicon tetrachloride (SiCl4) was slowly added at room temperature, and the reaction mixture was stirred continuously until thin-layer chromatography (TLC) monitoring showed complete disappearance of the feedstock. Subsequently, the reaction mixture was poured into water and extracted with dichloromethane (CH2Cl2). All organic phase extracts were combined and dried with anhydrous magnesium sulfate (MgSO4), followed by concentration under reduced pressure to remove the solvent. The residue was purified by recrystallization (petroleum ether-ether, 3:1) to give the pure products 2b-2g or 3b; or by silica gel column chromatography (hexane-ethyl acetate, 10:1 or 30:1) to give the pure products 2a, h, i, 3a-5 or 7-9.
References
[1] Journal of Organic Chemistry, 2014, vol. 79, # 1, p. 223 - 229
[2] Synthetic Communications, 2010, vol. 40, # 7, p. 998 - 1003
[3] Tetrahedron Letters, 2011, vol. 52, # 31, p. 4026 - 4029
[4] Patent: US2009/12171, 2009, A1. Location in patent: Page/Page column 11
[5] Patent: WO2005/105736, 2005, A1. Location in patent: Page/Page column 28
3-Bromobenzyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromobenzyl bromide Suppliers
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View Lastest Price from 3-Bromobenzyl bromide manufacturers
- Product
- 3-Bromobenzyl bromide 823-78-9
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- 3-Bromobenzyl bromide 823-78-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-29
- Product
- 3-Bromobenzyl bromide 823-78-9
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25