2-Amino-5-fluorobenzotrifluoride

Product Name: 2-Amino-5-fluorobenzotrifluoride
CAS No.: 393-39-5
Chemical Name: 2-Amino-5-fluorobenzotrifluoride
Synonyms: 2-Amino-5-fluorobenz;4-Fluoro-2-(Trifluoromethyl)an;α,α,α,4-Tetrafluoro-o-toluidine;5-FLUORO-2-AMINOBENZOTRIFLUORIDE;2-AMINO-5-FLUOROBENZOTRIFLUORIDE;4-FLUORO-2-(TRIFLUOROMETHYL)ANILINE;2-Amino-5-fluorobenzotrifluoride99%;2-(Trifluoromethyl)-4-fluoroaniline;2-Amino-5-fluorobenzotrifluoride 99%;2-Amino-5-fluorobenzotrifluoride >
CBNumber: CB6384344
Molecular Formula: C7H5F4N
Formula Weight: 179.11
MOL File: 393-39-5.mol

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2-Amino-5-fluorobenzotrifluoride Property

Boiling point:: 70-72 °C17.5 mm Hg(lit.)
Density: 1.38 g/mL at 25 °C(lit.)
refractive index: n20/D 1.464(lit.)
Flash point:: 162 °F
storage temp.: 2-8°C
pka: 1.52±0.10(Predicted)
form: clear liquid
color: Colorless to Yellow to Orange
Specific Gravity: 1.380
BRN: 2098758
CAS DataBase Reference: 393-39-5(CAS DataBase Reference)
NIST Chemistry Reference: Benzenamine, 4-fluoro-2-(trifluoromethyl)-(393-39-5)
EPA Substance Registry System: 4-Fluoro-2-(trifluoromethyl)aniline (393-39-5)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

H402Harmful to aquatic life

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 217751
Product name: 4-Fluoro-2-(trifluoromethyl)aniline
Purity: 99%
Packaging: 5g
Price: $84.4
Updated: 2022/05/15

TCI Chemical

Product number: A1158
Product name: 2-Amino-5-fluorobenzotrifluoride
Purity: >97.0%(GC)
Packaging: 5g
Price: $59
Updated: 2025/07/31

TCI Chemical

Product number: A1158
Product name: 2-Amino-5-fluorobenzotrifluoride
Purity: >97.0%(GC)
Packaging: 25g
Price: $178
Updated: 2025/07/31

TRC

Product number: A898198
Product name: 2-Amino-5-fluorobenzotrifluoride
Packaging: 5g
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3830-3-07
Product name: 2-Amino-5-fluorobenzotrifluoride
Purity: 97%
Packaging: 100g
Price: $60
Updated: 2021/12/16

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2-Amino-5-fluorobenzotrifluoride Chemical Properties,Usage,Production

Chemical Properties

clear light yellow to pale brown liquid

Uses

4-Fluoro-2-(trifluoromethyl)aniline was used in the preparation of 2-[4-(3-bromophenyl)-7-chloro-6-methyl-2-oxo-2H-chromen-3-yl]-N-[4-fluoro-2-(trifluoro-methyl)phenyl]acetamide.

Synthesis

2314-97-8

371-40-4

393-39-5

General procedure for the synthesis of 2-amino-5-fluorobenzotrifluoride from trifluoroiodomethane and 4-fluoroaniline: a 25 mL Schlenk tube was filled with a magnetic stirring bar, and 4-fluoroaniline (1.2 mmol, 3.0 eq.) or heterocyclic amine (0.8 mmol, 2.0 eq.), potassium carbonate (K2CO3, 0.8 mmol, 2.0 eq.) and fac- Ir(ppy)3 (2.6 mg, 0.004 mmol, 1 mol%). The reaction vessel was evacuated and displaced three times with argon (Ar), then trifluoroiodomethane (CF3I) stock solution (0.56 mL, 0.71 mmol/mL in 1,2-dichloroethane or 0.36 mL, 1.11 mmol/mL, 1.0 equiv in DMSO) and anhydrous 1,2-dichloroethane (3 mL) were added. The cap of the tube was screwed on tightly and the reaction was stirred for 24 h at room temperature under the illumination of a blue LED (12 W). Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and washed with ethyl acetate (3 x 5 mL). The filtrate was concentrated and the residue was purified by silica gel column chromatography to afford the target product 2-amino-5-fluorobenzotrifluoride.

References

[1] Tetrahedron Letters, 2017, vol. 58, # 41, p. 3939 - 3941

2-Amino-5-fluorobenzotrifluoride Preparation Products And Raw materials

Raw materials

2-Amino-5-chlorobenzotrifluoride

Preparation Products

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View Lastest Price from 2-Amino-5-fluorobenzotrifluoride manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-Fluoro-2-(trifluoromethyl)aniline 393-39-5
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-08

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Amino-5-fluorobenzotrifluoride 393-39-5
Price: US $0.00-0.00/KG
Min. Order: 50mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-08

Honest Joy Holdings Limited

Product: 2-amino-5-fluorobenzotrifluoride 393-39-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.6%
Supply Ability: 100 tons
Release date: 2022-02-18

393-39-5, 2-Amino-5-fluorobenzotrifluorideRelated Search:

4-Fluorobenzotrifluoride 3-Fluorobenzotrifluoride 2-Amino-5-chlorobenzotrifluoride Glycine Betaine 2-Methylbenzotrifluoride 2-Bromo-5-fluorobenzotrifluoride 1,2,4-Trimethylbenzene 1,4-Bis(trifluoromethyl)-benzene ALTRENOGEST Benzotrifluoride 2-Fluorobenzotrifluoride Dinitramine Aniline Tosufloxacin tosylate 2,3-DIAMINOTOLUENE 2-Aminobenzotrifluoride 2,4,6-Trinitrotoluene

4-Fluoro-2-(Trifluoromethyl)an

2-Amino-5-fluorobenzotrifluoride 99%

2-Amino-5-fluorobenzotrifluoride99%

ALPHA,ALPHA,ALPHA,4-TETRAFLUORO-ORTHO-TOLUIDINE

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4-fluoro-1-nitro-2-(trifluoromethyl)benzene,4-fluoro-2-trifluoromethylaniline

2-Amino-5-fluorobenzotrifluoride, α,α,α,4-Tetrafluoro-o-toluidine

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2-Amino-5-fluorobenzotrifluoride, 97% (4-Fluoro-2-(trifluoromethyl)aniline)

5-Fluoro–2-Nitrotrifluoromethylbenzene

2-Amino-5-fluorobenzotrifluoride ,98%

alpha,alpha,alpha,4-Tetrafluoro-o-toluidine,99%

4-Fluoro-2-(trifluoromethyl)aniline,2-Amino-5-fluorobenzotrifluoride, α,α,α,4-Tetrafluoro-o-toluidine

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2-(Trifluoromethyl)-4-fluoroaniline

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o-Toluidine, alpha,alpha,alpha,4-tetrafluoro-

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2-Amino-5-fluorobenzotrifluoride &gt

2-Amino-5-fluorotrifluoromethylbenzene

393-39-5

FC6H3CF3NH2

C7H5F4N

C7H5NF4

C7

Building Blocks

Amines

Organic Building Blocks

Nitrogen Compounds

AMINE

Trifluoromethylbenzene serise

Miscellaneous

Anilines, Aromatic Amines and Nitro Compounds

Aniline