2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID
- Product Name
- 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID
- CAS No.
- 17969-20-9
- Chemical Name
- 2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID
- Synonyms
- mialex;8L-323S;ici54,450;Fenclozic;fenclozicacid;acidofenclozico;acidumfenclozicum;Acide p-chlorophenyl-2;2-(p-chlorophenyl)-4-thiazoleaceticaci;2-(4-chlorophenyl)-4-thiazoleaceticaci
- CBNumber
- CB6384960
- Molecular Formula
- C11H8ClNO2S
- Formula Weight
- 253.7
- MOL File
- 17969-20-9.mol
2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Property
- Melting point:
- 150-152°C
- Boiling point:
- 145°C (rough estimate)
- Density
- 1.2270 (rough estimate)
- refractive index
- 1.6300 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.83±0.10(Predicted)
- color
- Off-White to Pale Brown
N-Bromosuccinimide Price
- Product number
- F247530
- Product name
- FenclozicAcid
- Packaging
- 500mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 045605
- Product name
- 2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
- Purity
- >95%
- Packaging
- 500mg
- Price
- $181
- Updated
- 2021/12/16
- Product number
- 045605
- Product name
- 2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
- Purity
- >95%
- Packaging
- 1g
- Price
- $228
- Updated
- 2021/12/16
- Product number
- FC124498
- Product name
- [2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
- Packaging
- 100mg
- Price
- $58
- Updated
- 2021/12/16
- Product number
- FC124498
- Product name
- [2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID Chemical Properties,Usage,Production
Originator
Fenclozic Acid,ZYF Pharm Chemical
Uses
Fenclozic Acid is a a potent antiinflammatory agent with analgesic and antipyretic properties and is a human hepatotoxic drug.
Manufacturing Process
3.7 parts of 2-(4-chlorophenyl)-4-cyanomethylthiazole and 35 parts of 6 N
hydrochloric acid are heated under reflux for 2 hours. The solution is cooled
by the addition of ice and made alkaline to pH 8 by the addition of 30%
aqueous ammonia. The mixture is filtered to remove trace impurities, and an
excess of 40% sodium hydroxide solution is then added to the filtrate to cause
precipitation of a sodium salt, which is collected by filtration and crystallised
from water. There is thus obtained sodium 2-(4-chlorophenyl)thiazol-4-
ylacetate, M.P. 13°C (decomposition).
This sodium salt is dissolved in hot water, and the solution is brought to pH 4
by the addition of acetic acid, which causes the precipitation of 2-(4-
chlorophenyl)thiazol-4-ylacetic acid. This is collected by filtration, washed with
water, and dried in vacuo over phosphorus pentoxide. It has an M.P. 155-
156°C (from ethyl acetate).
Therapeutic Function
Antiinflammatory, Analgesic, Antipyretic