3,4-DICHLOROISOTHIAZOLE-5-CARBOXYLIC ACID
Application- Product Name
- 3,4-DICHLOROISOTHIAZOLE-5-CARBOXYLIC ACID
- CAS No.
- 18480-53-0
- Chemical Name
- 3,4-DICHLOROISOTHIAZOLE-5-CARBOXYLIC ACID
- Synonyms
- Isotianil;Isotianil internate 1;3,4-Dichloro-5-carboxyisothiazole;Dichloro-1,2-thiazole-5-carboxylic acid;3,4-Dichloro-5-isothiazolecarboxylic acid;3,4-DICHLOROISOTHIAZOLE-5-CARBOXYLIC ACID;5-Isothiazolecarboxylic acid, 3,4dichloro;3,4-dichloro-1,2-thiazole-5-carboxylic acid;3,4-DICHLORO-5-ISOTHIAZOLE-3-CARBOXYLIC ACID
- CBNumber
- CB6389435
- Molecular Formula
- C4HCl2NO2S
- Formula Weight
- 198.03
- MOL File
- 18480-53-0.mol
3,4-DICHLOROISOTHIAZOLE-5-CARBOXYLIC ACID Property
- Melting point:
- 175-177°C
- Boiling point:
- 205.9±40.0 °C(Predicted)
- Density
- 1.824
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder
- pka
- 0.74±0.28(Predicted)
- color
- Off white
- InChI
- InChI=1S/C4HCl2NO2S/c5-1-2(4(8)9)10-7-3(1)6/h(H,8,9)
- InChIKey
- HQZKNCJWLIWCSV-UHFFFAOYSA-N
- SMILES
- S1C(C(O)=O)=C(Cl)C(Cl)=N1
- EPA Substance Registry System
- 3,4-Dichloro-5-isothiazolecarboxylic acid (18480-53-0)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D435033
- Product name
- 3,4-Dichloroisothiazole-5-carboxylicAcid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 019425
- Product name
- 3,4-Dichloroisothiazole-5-carboxylic acid
- Packaging
- 250mg
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 019425
- Product name
- 3,4-Dichloroisothiazole-5-carboxylic acid
- Packaging
- 1g
- Price
- $43
- Updated
- 2021/12/16
- Product number
- FD152096
- Product name
- 3,4-Dichloroisothiazole-5-carboxylicacid
- Packaging
- 100mg
- Price
- $83
- Updated
- 2021/12/16
- Product number
- CS-W021795
- Product name
- 3,4-Dichloroisothiazole-5-carboxylicacid
- Purity
- 96.53%
- Packaging
- 5g
- Price
- $140
- Updated
- 2021/12/16
3,4-DICHLOROISOTHIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production
Application
3,4-Dichloroisothiazol-5-carboxylic acid can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development processes and in the synthesis of pharmaceutical chemicals.
Synthesis
18480-52-9
18480-53-0
The general procedure for the synthesis of 3,4-dichloroisothiazole-5-carboxylic acid from 3,4-dichloro-5-cyanoisothiazole was as follows: 42.4 g of crude 3,4-dichloro-5-cyanoisothiazole was placed in three 500 mL round-bottomed flasks, and diluted by adding 100 mL of methanol and 30 g of 45% sodium hydroxide solution. The reaction was stirred at 40°C for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until 3,4-dichloro-5-cyanoisothiazole was completely disappeared. After completion of the reaction, the residual methanol was removed by concentration under reduced pressure. Subsequently, the pH of the reaction solution was adjusted to 3 with concentrated hydrochloric acid, the precipitate was collected by filtration and washed with cold water to afford 17.6 g of white solid 3,4-dichloroisothiazole-5-carboxylic acid (II). The product can be used directly in the subsequent reaction without further purification. Depending on the experimental requirements, the reaction can be scaled up or down to prepare different amounts of 3,4-dichloroisothiazole-5-carboxylic acid (II). This synthesis method has the same effect as the commercially available compounds.
References
[1] Patent: US5240951, 1993, A
[2] Patent: CN102942565, 2016, B. Location in patent: Paragraph 0015; 0022-0023; 0083-0084
3,4-DICHLOROISOTHIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4-DICHLOROISOTHIAZOLE-5-CARBOXYLIC ACID manufacturers
- Product
- 3,4-DICHLOROISOTHIAZOLE-5-CARBOXYLIC ACID 18480-53-0
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-21