(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE

Product Name: (5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE
CAS No.: 74588-78-6
Chemical Name: (5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE
Synonyms: D-6413;CS-888;D-64131;D 64131; D64131;D-64131(sc-203908);(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE;Methanone,(5-methoxy-1H-indol-2-yl)phenyl-;tubulin-inhibitory,D64131,Inhibitor,D-64131,G2/M,antiproliferative,inhibit,Microtubule/Tubulin,phase,carcinoma,antimitotic,activity,cytotoxicity,D 64131,astrocytoma
CBNumber: CB6390031
Molecular Formula: C16H13NO2
Formula Weight: 251.28
MOL File: 74588-78-6.mol

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(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE Property

Melting point:: 162 °C
Boiling point:: 455.2±25.0 °C(Predicted)
Density: 1.231±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO
pka: 14.81±0.30(Predicted)
form: Crystalline solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J65995
Product name: D-64131
Packaging: 10mg
Price: $154
Updated: 2021/12/16

Cayman Chemical

Product number: 22944
Product name: D-64131
Purity: ≥98%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 22944
Product name: D-64131
Purity: ≥98%
Packaging: 10mg
Price: $175
Updated: 2024/03/01

Cayman Chemical

Product number: 22944
Product name: D-64131
Purity: ≥98%
Packaging: 25mg
Price: $385
Updated: 2024/03/01

Cayman Chemical

Product number: 22944
Product name: D-64131
Purity: ≥98%
Packaging: 50mg
Price: $577
Updated: 2024/03/01

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(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE Chemical Properties,Usage,Production

Uses

Novel inhibitor of tubulin polymerization

Definition

ChEBI: (5-methoxy-1H-indol-2-yl)-phenylmethanone is a N-acylindole.

Biological Activity

Novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC 50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo .

References

1. beckers t, reissmann t, schmidt m et al. 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. cancer res. 2002 jun 1;62(11):3113-9.

(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE Suppliers

China 52 France 1 Germany 2 India 2 United Kingdom 1 United States 15 Global 73

VDM Biochemicals

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View Lastest Price from (5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE manufacturers

Career Henan Chemica Co

Product: (5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE 74588-78-6
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20tons
Release date: 2020-11-05

74588-78-6, (5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONERelated Search:

2,7-DIMETHOXY-5,10-DIMETHYL-5,10-DIHYDRO-INDOLO[3,2-B]QUINOLIN-11-ONE (5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE

D-64131

(5-METHOXY-1H-INDOL-2-YL)PHENYLMETHANONE

D-6413

D-64131(sc-203908)

CS-888

D 64131; D64131

Methanone,(5-methoxy-1H-indol-2-yl)phenyl-

tubulin-inhibitory,D64131,Inhibitor,D-64131,G2/M,antiproliferative,inhibit,Microtubule/Tubulin,phase,carcinoma,antimitotic,activity,cytotoxicity,D 64131,astrocytoma

74588-78-6

Inhibitors

Caspases/Apoptosis