1-BROMO-2-CHLORO-3-NITROBENZENE

Product Name: 1-BROMO-2-CHLORO-3-NITROBENZENE
CAS No.: 3970-37-4
Chemical Name: 1-BROMO-2-CHLORO-3-NITROBENZENE
Synonyms: oro-3-nitrobenzene;1-BROMO-2-CHLORO-3-NITROBENZENE;Benzene, 1-bromo-2-chloro-3-nitro-;1-BROMO-2-CHLORO-3-NITROBENZENE ISO 9001：2015 REACH
CBNumber: CB6391816
Molecular Formula: C6H3BrClNO2
Formula Weight: 236.45
MOL File: 3970-37-4.mol

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1-BROMO-2-CHLORO-3-NITROBENZENE Property

Melting point:: 57-60°C
Boiling point:: 290.4±20.0 °C(Predicted)
Density: 1.827±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: Pale Yellow
InChI: InChI=1S/C6H3BrClNO2/c7-4-2-1-3-5(6(4)8)9(10)11/h1-3H
InChIKey: JNIDAGAFFKAPRV-UHFFFAOYSA-N
SMILES: C1(Br)=CC=CC([N+]([O-])=O)=C1Cl

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Safety

HS Code: 2902900000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B682568
Product name: 1-Bromo-2-chloro-3-nitrobenzene
Packaging: 5g
Price: $225
Updated: 2021/12/16

Matrix Scientific

Product number: 074230
Product name: 1-Bromo-2-chloro-3-nitrobenzene
Purity: 95+%
Packaging: 5g
Price: $205
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB153849
Product name: 1-Bromo-2-chloro-3-nitrobenzene
Packaging: 5G
Price: $223
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB153849
Product name: 1-Bromo-2-chloro-3-nitrobenzene
Packaging: 2g
Price: $112
Updated: 2021/12/16

ChemScene

Product number: CS-W008709
Product name: 1-Bromo-2-chloro-3-nitrobenzene
Purity: 99.89%
Packaging: 10g
Price: $175
Updated: 2021/12/16

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1-BROMO-2-CHLORO-3-NITROBENZENE Chemical Properties,Usage,Production

Uses

1-Bromo-2-chloro-3-nitrobenzene is a reagent used in pharmaceutical synthesis. Used in the synthesis of benzodiazepinone bromodomain inhibitor CPI-?637 which may be applicable to cancer therapies.

Synthesis

3970-35-2

3970-37-4

General procedure for the synthesis of 1-bromo-2-chloro-3-nitrobenzene from 2-chloro-3-nitrobenzoic acid: 2-chloro-3-nitrobenzoic acid (15 g, 74.4 mmol) was dissolved in 350 mL of carbon tetrachloride under nitrogen protection and red mercuric oxide (24.3 g, 111.62 mmol) was added. The mixture was heated to 87°C under light conditions to reflux and bromine (5.75 mL, 111.6 mmol) was added slowly and dropwise. After the dropwise addition was completed, the reaction was continued at reflux for 3 h, followed by cooling to room temperature. The reaction mixture was quenched with saturated aqueous sodium bicarbonate solution, stirred for 10 min and filtered through a diatomaceous earth pad. The filter cake was further washed with dichloromethane. The organic layer was separated, washed sequentially with water and brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 11.55 g of 1-bromo-2-chloro-3-nitrobenzene in 67% yield. The product was detected by 400 MHz 1H NMR (CDCl3) with chemical shifts of δ 7.84 (d, 1H), 7.71 (d, 1H), 7.27 (dd, 1H); and mass spectra (M + 1) of 235, 237, 239.

References

[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 23, p. 4654 - 4666
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 20, p. 5392 - 5397
[3] Patent: WO2004/69832, 2004, A2. Location in patent: Page 126-127
[4] Patent: US2009/197932, 2009, A1. Location in patent: Page/Page column 5
[5] Patent: WO2008/12623, 2008, A1. Location in patent: Page/Page column 61

1-BROMO-2-CHLORO-3-NITROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BROMO-2-CHLORO-3-NITROBENZENE Suppliers

China 121 India 6 United Kingdom 2 United States 9 Global 138

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
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Alchem Pharmtech,Inc.

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Aladdin Scientific

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Aceschem Inc.

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Combi-Blocks Inc.

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Matrix Scientific

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Beta Pharma, Inc.

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Asymchem Laboratories, Inc.

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View Lastest Price from 1-BROMO-2-CHLORO-3-NITROBENZENE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1-Bromo-2-chloro-3-nitrobenzene 3970-37-4
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Puyang Huicheng Electronic Materials Co., Ltd.

Product: 1-bromo-2-chloro-3-nitrobenzene 3970-37-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.7%
Supply Ability: 200tons
Release date: 2023-02-15

Career Henan Chemical Co

Product: 1-BROMO-2-CHLORO-3-NITROBENZENE 3970-37-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

3970-37-4, 1-BROMO-2-CHLORO-3-NITROBENZENERelated Search:

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1-BROMO-2-CHLORO-3-NITROBENZENE

oro-3-nitrobenzene

Benzene, 1-bromo-2-chloro-3-nitro-

1-BROMO-2-CHLORO-3-NITROBENZENE ISO 9001：2015 REACH

3970-37-4