ChemicalBook > CAS DataBase List > o-Cresolphthalein

o-Cresolphthalein

Product Name
o-Cresolphthalein
CAS No.
596-27-0
Chemical Name
o-Cresolphthalein
Synonyms
cresolphthalein;o-Cresolphalein;o-Cresolphthalei;o-cresolphtaleine;O-CRESOLPHTHALEIN;O-Cresolphtnalein;o-cresolphehalein;Cresolphthanalein;3,3-Bis(4-hydroxy-;o-CRESOLPHTHLALEIN
CBNumber
CB6392671
Molecular Formula
C22H18O4
Formula Weight
346.38
MOL File
596-27-0.mol
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o-Cresolphthalein Property

Melting point:
223-225 °C
Boiling point:
401.12°C (rough estimate)
Density 
1.1425 (rough estimate)
refractive index 
1.4400 (estimate)
storage temp. 
room temp
solubility 
Solubility Slightly soluble in water; soluble in ethanol
form 
powder
pka
9.40(at 25℃)
color 
Clear colorless
PH Range
8.2 (colorless) - 9.8 (violet/red)
PH
8.2-9.8, colorless to red
Water Solubility 
slightly soluble
λmax
566nm, 381nm
ε(extinction coefficient)
≥10000 at 294-300nm
≥39000 at 564-570nm
≥5000 at 378-384nm
Merck 
14,2576
BRN 
310554
Major Application
Sensors, display device, photoresists, recording materials, imaging materials, authentication system for secure documents, decoder system, lithium cells, electroplating process, inks, markers, toners, correction fluid, paints, adhesives, floor coatings, gas leaking detector for safety in industries, toys, food storage, diapers, determination of calcium, lotions, urine analysis test strips, drugs, blood analysis
InChIKey
CPBJMKMKNCRKQB-UHFFFAOYSA-N
CAS DataBase Reference
596-27-0(CAS DataBase Reference)
EPA Substance Registry System
1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-3-methylphenyl)- (596-27-0)
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Safety

Hazard Codes 
Xn
Risk Statements 
40-36/37/38-20/21/22
Safety Statements 
36/37-36-26
RIDADR 
1170
WGK Germany 
3
RTECS 
SM8390000
TSCA 
Yes
HS Code 
3822.19.0080
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H340May cause genetic defects

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C85778
Product name
o-Cresolphthalein
Purity
indicator grade
Packaging
10g
Price
$60.5
Updated
2025/07/31
TCI Chemical
Product number
C0404
Product name
o-Cresolphthalein
Packaging
25g
Price
$65
Updated
2025/07/31
TCI Chemical
Product number
C0404
Product name
o-Cresolphthalein
Packaging
100g
Price
$171
Updated
2025/07/31
TCI Chemical
Product number
C0218
Product name
o-Cresolphthalein (0.04% in ca. 95% Ethanol) [for pH Determination]
Packaging
100ML
Price
$47
Updated
2023/06/20
TRC
Product number
C782155
Product name
o-Cresolphthalein
Packaging
1g
Price
$65
Updated
2021/12/16
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o-Cresolphthalein Chemical Properties,Usage,Production

Chemical Properties

white to pink or beige to tan powder. soluble in ethanol, ether, glacial acetic acid, soluble in dilute alkali and turns purple, slightly soluble in water, hardly soluble in benzene.

Uses

O-Cresolphthalein has been used as a component in calcifying media for calcification assay. It is also used as an indicator (pH range, 8.2 colorless, 9.8 red) and analytical reagent.

Application

O-Cresolphthalein is a gadolinium chelate that is used as a contrast agent for magnetic resonance imaging (MRI) of the brain, spine, and joints. The gadolinium ion is bound to the cresol molecule, which has an attached hydroxyl group. This complex attaches to the phosphorous pentoxide and creates a precipitate of metal hydroxides in the presence of water and sodium carbonate. O-Cresolphthalein is also used in clinical pathology to measure glomerular filtration rate (GFR), which is important for diagnosing renal disease. MRI scans are used to diagnose osteogenic genes that are associated with bone diseases such as osteoporosis.

Biochem/physiol Actions

o-Cresolphthalein is a reversible pH indicator. The kinetics of the reverse pathway (red-purple to colorless) is slow, thereby making it an appropriate molecule to check flow patterns in ducts with corrugated walls. It is also used for the colorimetric determination of calcium content via the o-cresolphthalein complexone method. Binding of calcium to o-cresolphthalein, in the presence of alkaline conditions (pH 10-12), results in the formation of a red complex with an absorbance at 570-575nm.

o-Cresolphthalein Preparation Products And Raw materials

Raw materials

ORTHO TOLUENE Zinc chloride o-Cresol Dilute hydrochloric acid

Preparation Products

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View Lastest Price from o-Cresolphthalein manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
o-Cresolphthalein 596-27-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-09-24
Hebei Chuanghai Biotechnology Co., Ltd
Product
o-Cresolphthalein 596-27-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2025-03-12
Watson Biotechnology Co.,Ltd
Product
o-Cresolphthalein 596-27-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2025-02-18

596-27-0, o-CresolphthaleinRelated Search:

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  • 3’,3’’-dimethyl-phenolphthalei
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  • 3,3-bis(4-hydroxy-3-methylphenyl)-(3H)-Isobenzofuranone
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  • 3,3-Bis(3-methyl-4-hydroxyphenyl)isobenzofuran-1(3H)-one
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  • o-Cresolphthalein - Cas NO.: 596-27-0
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