1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride

Product Name: 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
CAS No.: 79547-78-7
Chemical Name: 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
Synonyms: 547;R50547;LEVOSTIN;LIVOSTIN;LEVOPHTA;Unii-124xma6yei;LEVOCABASTINE HCL;(3S,4R)-Cabastine;LIVOSTIN USP/EP/BP;(3S,4R)-Cabastine HCl
CBNumber: CB6411376
Molecular Formula: C26H30ClFN2O2
Formula Weight: 456.99
MOL File: 79547-78-7.mol

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1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Property

storage temp.: 2-8°C
solubility: DMSO: ~10 mg/mL, soluble
form: solid
color: white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2933399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1359856
Product name: Levocabastine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 50mg
Price: $483
Updated: 2024/03/01

Sigma-Aldrich

Product number: L3042
Product name: Levocabastine hydrochloride
Purity: ≥99% (HPLC), solid
Packaging: 5mg
Price: $255
Updated: 2023/06/20

Cayman Chemical

Product number: 21014
Product name: Levocabastine (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21014
Product name: Levocabastine (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001637
Product name: Levocabastine for system suitability 2
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001637
Price: $150
Updated: 2024/03/01

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1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Chemical Properties,Usage,Production

Description

Levocabastine hydrochloride is a new, highly potent and specific histamine HI-receptor antagonist without anticholinergic or antiserotonergic side effects. It is reported to have both a fast onset and long duration of action. Indications are the treatment of allergic conjunctivitis and allergic rhinitis.

Chemical Properties

White or almost white powder.

Originator

Janssen (Johnson & Johnson) (U.S.A.)

Uses

A histamine H1 receptor antagonist used in allergic conjunctivitis.

Definition

ChEBI: Livostin (TN) is a member of piperidines.

Manufacturing Process

4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is synthesized an intermediate that after decarboethoxylation gives 1-(4- fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5- phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4- oxycyclohexanecarbonitrile under reductive hydrogenation conditions (palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4- piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl- 4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4- fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl) cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))- (Levocabastine hydrochloride)

brand name

Livostin (Novartis).

Therapeutic Function

Antihistaminic

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Suppliers

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View Lastest Price from 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride manufacturers

Dideu Industries Group Limited

Product: 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 79547-78-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-26

79547-78-7, 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochlorideRelated Search:

AMTHAMINE DIHYDROBROMIDE Levomepromazine hydrochloride Cyclohexanol TRIS(PENTAFLUOROPHENYL)PHOSPHINE 2-FLUOROPHENYL CYCLOPENTYL KETONE Azelastine hydrochloride Astemizole Ketotifen fumarate Levamisole hydrochloride Levocetirizine dihydrochloride 6-[2-(4-IMIDAZOLYL)ETHYLAMINO]-N-(4-TRIFLUOROMETHYLPHENYL)HEPTANECARBOXAMIDE DIMALEATE thioperamide maleate salt (R)-(-)-α-Methylhistamine dihydrobromide 1-(4-FLUOROPHENYL)CYCLOHEXANECARBONITRILE 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride LEVOCABASTINE 1-ISOPROPYL-PIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE 4-PHENYL-4-PIPERIDINE CARBOXYLIC ACID

R50547

LIVOSTIN

[3s-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid

4-Piperidinecarboxylic acid, 1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, monohydrochloride, [3S-[1(cis),3a,4b]]-

4-Piperidinecarboxylic acid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, monohydrochloride, (3S,4R)- (9CI)

Levophta, Levostin, R50547, [3S-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid

LEVOPHTA

LEVOCABASTINE HCL

LEVOCABASTINE HYDROCHLORIDE

LEVOSTIN

[3S-[1(CIS),3ALPHA,4BETA]]-1-[4-CYANO-4-(4-FLUOROPHENYL)CYCLOHEXYL]-3-METHYL-4-PHENYL-4-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE

4-Piperidinecarboxylic acid, 1-(cis-4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, monohydrochloride, (3S,4R)-

Unii-124xma6yei

(3S,4R)-Cabastine

Levocabastine Hydrochloride (50 mg)

(3S,4R)-Cabastine Hydrochloride

Levocabastine for system suitability 2

(3S,4R)-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylicacid,hydrochloride

Levocabastine for system suitability 1 CRS

Levocabastine hydrochloride CRS

Levocabastine for system suitability 2 CRS

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride

(3S,4R)-1-[cis-4-Cyano-4-(4-fluorophenyl)cyclohexyl]- 3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride

LIVOSTIN USP/EP/BP

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride USP/EP/BP

Levocabastine Hydrochloride (1359856)

547

(3S,4R)-Cabastine HCl

4-Piperidinecarboxylicacid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-,hydrochloride (1:1), (3S,4R)-

79547-78-7

C26H30ClFN2O2

C26H29N2O2FHCl

C26H29FN2O2HCl

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Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals