ChemicalBook > CAS DataBase List > 2,2',5,5'-Tetrachlorobenzidine

2,2',5,5'-Tetrachlorobenzidine

Product Name: 2,2',5,5'-Tetrachlorobenzidine
CAS No.: 15721-02-5
Chemical Name: 2,2',5,5'-Tetrachlorobenzidine
Synonyms: TCB;PK3;OIP3;PKM1 active human;2,2',5,5'-Tetrachlor;2,2’,5,5’-tetrachloro-benzidin;3,3’,6,6’-tetrachlorobenzidine;2,2',5,5'-tetrachlorobenzidine;2,2',5,5'-tetrachlorobenzidine;2,2,5,5-TETRACHLOROBENZIDINE 98+%
CBNumber: CB6411730
Molecular Formula: C12H8Cl4N2
Formula Weight: 322.02
MOL File: 15721-02-5.mol

Less

2,2',5,5'-Tetrachlorobenzidine Property

Melting point:: 135-140 °C(lit.)
Boiling point:: 477.67°C (rough estimate)
Density: 1.5309 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: -70°C
solubility: soluble in Methanol
form: powder to crystal
pka: 1.58±0.13(Predicted)
color: Light yellow to Yellow to Orange
biological source: human
Water Solubility: water: soluble
CAS DataBase Reference: 15721-02-5(CAS DataBase Reference)
IARC: 3 (Vol. 27, Sup 7) 1987
EPA Substance Registry System: [1,1'-Biphenyl]-4,4'-diamine, 2,2',5,5'-tetrachloro- (15721-02-5)

Less

Safety

Hazard Codes: T
Risk Statements: 61
Safety Statements: 53-45
WGK Germany: 3
RTECS: DD1751000
HS Code: 2921.59.8090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SRP0415
Product name: PKM1 active human
Purity: recombinant, expressed in <I>E. coli</I>, ≥80% (SDS-PAGE)
Packaging: 20 μg
Price: $672
Updated: 2025/07/31

Sigma-Aldrich

Product number: SRP0415
Product name: PKM1 active human
Purity: recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Packaging: 20μG
Price: $653
Updated: 2024/03/01

TCI Chemical

Product number: T0933
Product name: 2,2',5,5'-Tetrachlorobenzidine
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $66
Updated: 2025/07/31

TCI Chemical

Product number: T0933
Product name: 2,2',5,5'-Tetrachlorobenzidine
Purity: >98.0%(HPLC)(N)
Packaging: 500g
Price: $547
Updated: 2025/07/31

TRC

Product number: T204568
Product name: 2,2'',5,5''-Tetrachlorobenzidine
Packaging: 250mg
Price: $45
Updated: 2021/12/16

Less

2,2',5,5'-Tetrachlorobenzidine Chemical Properties,Usage,Production

Uses

PKM1active human has been used in:

cell-based kinase assay to study the ability of a compound to inhibit the kinase activity of PKM1.
oxidative stress experiments on PKM2.
Co-immunoprecipitation (Co-IP) to determine pyruvate kinase M2 (PKM2) as a novel direct binding partner of phosphoserine aminotransferase 1 (PSAT1).

Definition

ChEBI: 2,2',5,5'-Tetrachlorobenzidine is a member of biphenyls and a dichlorobenzene.

Production Methods

2,2' ,5,5' -Tetrachlorobenzidine is made by the reduction of 2,5-dichloronitrobenzene with zinc dust and sodium hydroxide solution. The subsequent rearrangement is carried out using sulfuric acid or hydrochloric acid. The dihydrochloride melts at 230 ℃. Tetrachlorobenzidine is marketed as the free base and is used to produce yellow pigments.

Biological Activity

Pyruvate kinase (PK) catalyzes the dephosphorylation of phosphoenolpyruvate(PEP) into pyruvate. It is also involved in glycolysis by releasing ATP.Allosteric effects and intracellular signal transduction regulate the enzymaticactivity of PKM1. PKM1 is involved in several biological processes such asmetabolic reprogramming, and innate and acquired immune response. Itparticipates in protein interactions, protein synthesis, glycolysis, andintranuclear signal transduction.

Safety Profile

Suspected carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and Cl-.

2,2',5,5'-Tetrachlorobenzidine Preparation Products And Raw materials

Raw materials

Preparation Products

Pigment Yellow 81

Less

2,2',5,5'-Tetrachlorobenzidine Suppliers

Canada 1 China 135 Germany 3 India 9 Japan 3 Norway 1 South Korea 1 Switzerland 1 United Kingdom 4 United States 15 Global 173

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Dtchem Laboratories,（Gan Su）Co.,Ltd.

Tel: 18993966060
Fax: 0943-8288977
Email: sales@techbiochem.com
Country: China
ProdList: 806
Advantage: 61

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Huainan Kedi Chemical Factory

Tel: 0554-2106669
Fax: 0554-2666215
Email: sales1@kedichem.com
Country: China
ProdList: 4924
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5872
Advantage: 58

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-0431-80514535 19917294565
Email: et@chemextension.com
Country: China
ProdList: 3935
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9941
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20794
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13305
Advantage: 58

Shanghai Orgchem Co.,Ltd.

Tel: +86-21-5877 1921
Fax: +86-21-5877 1925
Email: info@chemofchina.com
Country: China
ProdList: 9653
Advantage: 55

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 021-021-52271985 17721149837
Fax: +86 (21) 52271987
Email: sales@9dingchem.com
Country: China
ProdList: 19800
Advantage: 60

Shanghai BaiShun Biological Technology Co., Ltd

Tel: 021-37581181
Fax: 021-57456066
Email: sales@chem-mall.com
Country: China
ProdList: 10330
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai Shuai Sun Industrial Co., Ltd.

Tel: 021-37590756 57450129
Fax: 021-57450128
Country: China
ProdList: 4284
Advantage: 58

GUANGZHOU CHANGTHINKING IMP.&EXP.CO.,LTD

Tel: 020-37651955 13682223272
Fax: 020-87659730
Email: 173901442@qq.com
Country: China
ProdList: 694
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Suzhou Adelaide Chemical Technology Co., Ltd.

Tel: 15995785122
Email: 3003020078@qq.com
Country: China
ProdList: 1198
Advantage: 58

Beijing Minruida Technology Co., Ltd.

Tel: 010-82387566 18001021521;
Fax: 82387566-801
Email: sales@mreda.com.cn
Country: China
ProdList: 10083
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Zhejiang Lianshuo Biotechnology Co., Ltd.

Tel: 18616526224
Email: lianshuo@vip.126.com
Country: China
ProdList: 9607
Advantage: 58

Shanghai Jiange Chemical Co., Ltd.

Tel: 15921040873
Email: 1434142450@qq.com
Country: CHINA
ProdList: 7649
Advantage: 58

Shandong chuangyingchemical Co., Ltd.

Tel: 18853181302
Email: sale@chuangyingchem.com
Country: CHINA
ProdList: 5906
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Less

View Lastest Price from 2,2',5,5'-Tetrachlorobenzidine manufacturers

Hebei Ganmiao New material Technology Co., LTD

Product: 2,2',5,5'-Tetrachlorobenzidine 15721-02-5
Price: US $10.00-7.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20ton
Release date: 2024-06-05

Henan Fengda Chemical Co., Ltd

Product: 2,2',5,5'-Tetrachlorobenzidine 15721-02-5
Price: US $8.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-24

Career Henan Chemical Co

Product: 2,2',5,5'-Tetrachlorobenzidine 15721-02-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-22

15721-02-5, 2,2',5,5'-TetrachlorobenzidineRelated Search:

HYDRAZINE Biphenyl 3,3'-Dichlorobenzidine Sodium diphenylamine-4-sulfonate 4-Aminodiphenylamine Diphenylamine 2,2',5-TRICHLOROBIPHENYL 2,5-DICHLOROTOLUENE 3,3'-Dichlorobenzidine dihydrochloride 2,3',5-TRICHLOROBIPHENYL Benzidine dihydrochloride Pigment Yellow 81 2,5-DICHLOROBIPHENYL 2,2'-dichlorobenzidine 2-CHLOROBIPHENYL 2,2'-DICHLOROBIPHENYL 3-CHLOROBIPHENYL 2,2',5,5'-TETRACHLOROBIPHENYL

4-(4-aminophenyl)-N,N,2,3-tetrachloroaniline

4,4'-diamino-5,5',2,2'-tetrachlorobiphenyl

2,2,5,5-TETRACHLORO-4,4-DIAMINOBIPHENYL

2,2,5,5-TETRACHLOROBENZIDINE 98+%

4,4'-DIAMINO-2,2',5,5'-TETRACHLOROBIPHENYL

2,2',5,5'-Tetrachlorobiphenyl-4,4'-diamine

TCB

Benzidine, 2,2',5,5'-tetrachloro-

2,2',5,5'-Tetrachlor

OIP3

PK3

PKM1 active human

2,2’,5,5’-tetrachloro-benzidin

3,3’,6,6’-tetrachlorobenzidine

1’-biphenyl)-4,4’-diamine,2,2’,5,5’-tetrachloro-(

1’-biphenyl]-4,4’-diamine,2,2’,5,5’-tetrachloro-[

2,2’,5,5’-tetrachloro-4,4’-diaminodiphenyl

[1,1'-Biphenyl]-4,4'-diamine, 2,2',5,5'-tetrachloro-

2,2',5,5'-Tetrachlorobenzidine ISO 9001：2015 REACH

2,2',5,5'-tetrachlorobenzidine

2,2',5,5'-Tetrachloro-[1,1'-biphenyl]-4,4'-diamine

2,2',5,5'-Tetrachloro-4,4'-biphenyldiamine

2,2',5,5'-Tetrachlorobenzidine in isooctane

2,2',5,5'-Tetrachloro-4,4'-biphenyldiamine

2,2′,5,5′-Tetrachlorobenzidine, CAS 15721-02-5

2,2',5,5'-tetrachlorobenzidine

15721-02-5

-C6H2Cl24NH22

C12H8Cl4N2

Biphenyl & Diphenyl ether

Intermediates of Dyes and Pigments