6-DIAZO-5-OXO-L-NORLEUCINE

ChemicalBook > CAS DataBase List > 6-DIAZO-5-OXO-L-NORLEUCINE

6-DIAZO-5-OXO-L-NORLEUCINE

Product Name: 6-DIAZO-5-OXO-L-NORLEUCINE
CAS No.: 157-03-9
Chemical Name: 6-DIAZO-5-OXO-L-NORLEUCINE
Synonyms: DON;L-DON;D2141;NSC-7365;H-L-Don-OH;don(pharmaceutical);diazo-oxo-norleucine;H-6-DIAZO-5-OXO-NLE-OH;H-NLE(6-DIAZO-5-OXO)-OH;L-Nle(6-Diazo-5-oxo)-OH
CBNumber: CB6413936
Molecular Formula: C6H9N3O3
Formula Weight: 171.15
MOL File: 157-03-9.mol

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6-DIAZO-5-OXO-L-NORLEUCINE Property

Melting point:: 145 °C
Boiling point:: 301.12°C (rough estimate)
Density: 1.3994 (rough estimate)
refractive index: 1.5800 (estimate)
storage temp.: -20°C
solubility: DMSO (Slightly, Heated, Sonicated), Water (Slightly)
form: crystalline
color: light yellow
Merck: 13,3026
BRN: 1725815
Stability:: Hygroscopic
InChI: InChI=1/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/s3
InChIKey: YCWQAMGASJSUIP-GQMHJJTINA-N
SMILES: C(C(=O)C=[N+]=[N-])C[C@H](N)C(=O)O |&1:7,r|

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Safety

Hazard Codes: T
Risk Statements: 23/24/25
Safety Statements: 36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: RC6340000
F: 8

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D2141
Product name: 6-Diazo-5-oxo-L-norleucine
Purity: crystalline
Packaging: 5mg
Price: $71.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: D2141
Product name: 6-Diazo-5-oxo-L-norleucine
Purity: crystalline
Packaging: 25mg
Price: $246
Updated: 2024/03/01

Cayman Chemical

Product number: 17580
Product name: 6-diazo-5-oxo-L-nor-Leucine
Purity: ≥95%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 17580
Product name: 6-diazo-5-oxo-L-nor-Leucine
Purity: ≥95%
Packaging: 10mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 17580
Product name: 6-diazo-5-oxo-L-nor-Leucine
Purity: ≥95%
Packaging: 25mg
Price: $213
Updated: 2024/03/01

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6-DIAZO-5-OXO-L-NORLEUCINE Chemical Properties,Usage,Production

Chemical Properties

Slightly yellow powder

Uses

6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.

Definition

ChEBI: 6-diazo-5-oxo-L-norleucine is a non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes. It has a role as a bacterial metabolite, an analgesic, an antibacterial agent, an antiviral agent, an antineoplastic agent, an EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor, an EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor, an EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor, an EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor, an antimetabolite, a glutamine antagonist, an apoptosis inducer, an EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor, an EC 3.5.1.2 (glutaminase) inhibitor, an EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor and an EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor. It is a non-proteinogenic L-alpha-amino acid, a diazo compound and a ketone. It is a tautomer of a 6-diazo-5-oxo-L-norleucine zwitterion.

General Description

Chemical structure: amino acid derivatives

Biochem/physiol Actions

DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.

Purification Methods

Crystallise it from EtOH, H2O/EtOH, MeOH, 95% aqueous MeOH or H2O/Me2CO. [DeWald & Moor J Am Chem Soc 80 3944 1958, Dion et al. J Am Chem Soc 78 3075 1956, Beilstein 4 IV 3278.]

6-DIAZO-5-OXO-L-NORLEUCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-DIAZO-5-OXO-L-NORLEUCINE manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 6-Diazo-5-oxo-L-norleucine 157-03-9
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-27

Shaanxi Dideu Medichem Co. Ltd

Product: 6-Diazo-5-oxo-l-norleucine 157-03-9
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000Tons
Release date: 2024-07-13

Shaanxi Dideu Medichem Co. Ltd

Product: 6-DIAZO-5-OXO-L-NORLEUCINE 157-03-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20T
Release date: 2024-05-26

157-03-9, 6-DIAZO-5-OXO-L-NORLEUCINERelated Search:

6-Mercaptopurine 8-AZAGUANINE 6-Thioguanine AZASERINE 6-DIAZO-5-OXO-D-NORLEUCINE,H-6-DIAZO-5-OXO-D-NORLEUCINE,(R)-2-Amino-6-diazo-5-oxocaproic acid, (R)-6-Diazo-5-oxo-L-norleucine Diazomethane 6-DIAZO-5-OXO-L-NORLEUCINE Alazopeptin 4-acetylbutyric acid Diazomycin B

6-diazo-5-oxo,l-norleucin

6-diazo-5-oxo-l-norleucin

diazo-oxo-norleucine

don(pharmaceutical)

6-DIAZO-5-OXO-L-2-AMINOHEXANOIC ACID

6-DIAZO-5-OXO-L-NORLEUCINE

6-DIAZO-5-OXO-NORLEUCINE

L-DON

DON

H-6-DIAZO-5-OXO-L-NORLEUCINE

H-6-DIAZO-5-OXO-NLE-OH

H-NLE(6-DIAZO-5-OXO)-OH

(S)-2-AMINO-6-DIAZO-5-OXOCAPROIC ACID

(S)-2-Amino-6-diazo-5-oxocaproic acid, (S)-6-Diazo-5-oxo-L-norleucine

H-L-Don-OH

(S)-2-Amino-6-diazo-5-oxocaproic acid, DON

5-Oxo-6-diazo-L-norleucine

NSC-7365

L-Norleucine, 6-diazo-5-oxo-

(S)-2-aMino-6-diazo-5-oxohexanoic acid

L-DON, 6-Diazo-5-oxo-L-2-aMinohexanoic acid, H-Glu(diazoMethylketone)-OH

6-Diazo-5-oxo-L-norleucine≥ 99% (TBAH, Titration)

L-Nle(6-Diazo-5-oxo)-OH

D2141

(2S)-2-amino-6-diazo-5-oxohexanoic acid

L-6-Diazo-5-oxonorleucine

6-Diazo-5-oxo-L-norleucine crystalline

6-DIAZO-5-OXO-L-NORLEUCINE USP/EP/BP

Diazo-5-oxo-L-norleucine

6-Diazo-5-oxo-l-norleucine(L-DON,DON)

6-DIAZO-6-OXO-L-NORLEUCINE

Diazo-5-oxo-L-norleucine, 6-

157-03-9

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