6-DIAZO-5-OXO-L-NORLEUCINE
- Product Name
- 6-DIAZO-5-OXO-L-NORLEUCINE
- CAS No.
- 157-03-9
- Chemical Name
- 6-DIAZO-5-OXO-L-NORLEUCINE
- Synonyms
- DON;L-DON;D2141;NSC-7365;H-L-Don-OH;don(pharmaceutical);diazo-oxo-norleucine;H-6-DIAZO-5-OXO-NLE-OH;H-NLE(6-DIAZO-5-OXO)-OH;L-Nle(6-Diazo-5-oxo)-OH
- CBNumber
- CB6413936
- Molecular Formula
- C6H9N3O3
- Formula Weight
- 171.15
- MOL File
- 157-03-9.mol
6-DIAZO-5-OXO-L-NORLEUCINE Property
- Melting point:
- 145 °C
- Boiling point:
- 301.12°C (rough estimate)
- Density
- 1.3994 (rough estimate)
- refractive index
- 1.5800 (estimate)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly, Heated, Sonicated), Water (Slightly)
- form
- crystalline
- color
- light yellow
- Merck
- 13,3026
- BRN
- 1725815
- Stability:
- Hygroscopic
- InChI
- InChI=1/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/s3
- InChIKey
- YCWQAMGASJSUIP-GQMHJJTINA-N
- SMILES
- C(C(=O)C=[N+]=[N-])C[C@H](N)C(=O)O |&1:7,r|
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25
- Safety Statements
- 36/37/39-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- RC6340000
- F
- 8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D2141
- Product name
- 6-Diazo-5-oxo-L-norleucine
- Purity
- crystalline
- Packaging
- 5mg
- Price
- $71.1
- Updated
- 2024/03/01
- Product number
- D2141
- Product name
- 6-Diazo-5-oxo-L-norleucine
- Purity
- crystalline
- Packaging
- 25mg
- Price
- $246
- Updated
- 2024/03/01
- Product number
- 17580
- Product name
- 6-diazo-5-oxo-L-nor-Leucine
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 17580
- Product name
- 6-diazo-5-oxo-L-nor-Leucine
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 17580
- Product name
- 6-diazo-5-oxo-L-nor-Leucine
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $213
- Updated
- 2024/03/01
6-DIAZO-5-OXO-L-NORLEUCINE Chemical Properties,Usage,Production
Chemical Properties
Slightly yellow powder
Uses
6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.
Definition
ChEBI: 6-diazo-5-oxo-L-norleucine is a non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes. It has a role as a bacterial metabolite, an analgesic, an antibacterial agent, an antiviral agent, an antineoplastic agent, an EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor, an EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor, an EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor, an EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor, an antimetabolite, a glutamine antagonist, an apoptosis inducer, an EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor, an EC 3.5.1.2 (glutaminase) inhibitor, an EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor and an EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor. It is a non-proteinogenic L-alpha-amino acid, a diazo compound and a ketone. It is a tautomer of a 6-diazo-5-oxo-L-norleucine zwitterion.
General Description
Chemical structure: amino acid derivatives
Biochem/physiol Actions
DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.
Purification Methods
Crystallise it from EtOH, H2O/EtOH, MeOH, 95% aqueous MeOH or H2O/Me2CO. [DeWald & Moor J Am Chem Soc 80 3944 1958, Dion et al. J Am Chem Soc 78 3075 1956, Beilstein 4 IV 3278.]
6-DIAZO-5-OXO-L-NORLEUCINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-DIAZO-5-OXO-L-NORLEUCINE manufacturers
- Product
- 6-Diazo-5-oxo-L-norleucine 157-03-9
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-27
- Product
- 6-Diazo-5-oxo-l-norleucine 157-03-9
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000Tons
- Release date
- 2024-07-13
- Product
- 6-DIAZO-5-OXO-L-NORLEUCINE 157-03-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-05-26