ChemicalBook > CAS DataBase List > 15-28-Somatostatin-28

15-28-Somatostatin-28

Product Name
15-28-Somatostatin-28
CAS No.
38916-34-6
Chemical Name
15-28-Somatostatin-28
Synonyms
SRIF;SS-14;GH-RIF;SRIF-A;Aminopan;Stilamin;Somatofalk;Modustatina;Somatostatina;Somatostatine
CBNumber
CB6417646
Molecular Formula
C76H104N18O19S2
Formula Weight
1637.88
MOL File
38916-34-6.mol
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15-28-Somatostatin-28 Property

Melting point:
>211°C (dec.)
Boiling point:
1970.9±65.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
H2O: 1 mg/mL
form 
powder
pka
2.94±0.70(Predicted)
color 
White to Off-White
Water Solubility 
Soluble in water(25,00°C 1,00 g/L), Methanol.
Merck 
13,8788
BRN 
6436064
Sequence
Ala-Gly-c[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys]-OH,(Disulfide bridge: Cys-Cys)
InChI
InChI=1/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/s3
InChIKey
NHXLMOGPVYXJNR-ATOGVRKGSA-N
SMILES
C12C=CC=CC=1NC=C2C[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@H](C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](N)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC2C=CC=CC=2)C(=O)N[C@@H](CC2C=CC=CC=2)C(=O)N1)C(=O)O)CC1C=CC=CC=1 |&1:10,14,23,24,30,34,35,41,47,52,60,66,75,83,94,r|
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Safety

WGK Germany 
3
RTECS 
WF8751700
F 
3-10-21
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S9129
Product name
Somatostatin
Purity
≥97%(HPLC),powder
Packaging
0.5mg
Price
$95
Updated
2024/03/01
Sigma-Aldrich
Product number
S1763
Product name
Somatostatin
Purity
powder,BioReagent,suitableforcellculture
Packaging
0.1mg
Price
$59.1
Updated
2024/03/01
Sigma-Aldrich
Product number
S0885
Product name
Somatostatin
Purity
powder,γ-irradiated,BioXtra,suitableforcellculture
Packaging
20μg
Price
$40.68
Updated
2024/03/01
Alfa Aesar
Product number
J66168
Product name
Somatostatin 14
Packaging
5mg
Price
$157
Updated
2023/06/20
Sigma-Aldrich
Product number
S9129
Product name
Somatostatin
Purity
≥97% (HPLC), powder
Packaging
1mg
Price
$108
Updated
2024/03/01
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15-28-Somatostatin-28 Chemical Properties,Usage,Production

Chemical Properties

White Powder

Uses

Growth hormone-release inhibiting factor; treatment of severe, acute hemorrhage of gastroduodenal ulcers; experimental antidiabetic.

Definition

ChEBI: A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.

Biological Functions

Somatostatin is a cyclic 14-peptide that was first isolated by Guillemin in 1973 and is probably the most thoroughly investigated and most important of the inhibitory factors produced by the hypothalamus. The principal activity of somatostatin, which is of hypothalamic origin, is inhibition of the release of growth hormone (GH) from the anterior pituitary. Too much GH, as in pituitary tumors, causes acromegaly, a form of giantism. On the other hand, too little GH leads to dwarfism. Somatostatin also has been found in the pancreas and the GI tract, where it inhibits the secretion of both insulin and glucagon from the pancreas as well as the secretion of a variety of intestinal peptides (e.g., gastrin, secretin, pepsin, and renin). The short half-life of somatostatin, which is less than 3 minutes, has precluded its use as a therapeutic agent. Many derivatives of somatostatin have been prepared to increase its duration of action and/or to enhance its selectivity of action. The culmination of these structure–activity studies was the development of octreotide acetate.

General Description

Somatostatin (SST) is a peptide.

Biochem/physiol Actions

Somatostatin regulates the secretion of hormones and bioactive peptides. It acts as an inhibitor in the digestive tract by inhibiting gastrin release. In the pancreatic islets, it inhibits glucagon and insulin release. Somatostatin and its synthetic analogs have been used in the treatment of neuroendocrine tumors.

Purification Methods

Somatostatin is a tetradecapeptide which is purified by gel filtration on Sephadex G-25, eluting with 2N AcOH, and then by liquid partition chromatography on Sephadex G-25 using n-BuOH/AcOH/H2O (4:1:5) and has RF = 0.4. It is a brain growth hormone releasing-inhibiting factor which has also been synthesised. [Burgus et al. Proc Natl Acad Sci USA 70 684 1973, Sorantakis & McKinley Biochem Biophys Res Commun 54 234 1973, Hartridt et al. Pharmazie 37 403 1982.]

15-28-Somatostatin-28 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 15-28-Somatostatin-28 manufacturers

Nantong Guangyuan Chemicl Co,Ltd
Product
Somatostatin-14 38916-34-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-10-13
Zibo Hangyu Biotechnology Development Co., Ltd
Product
15-28-Somatostatin-28 38916-34-6
Price
US $65.00-650.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-02
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Somatostatin Acetate 38916-34-6
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
1000g
Release date
2022-01-10

38916-34-6, 15-28-Somatostatin-28Related Search:

SOMATOSTATIN 28, CYCLIC Somatostatin Oxytocin Bivalirudin H-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH H-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH H-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-OH H-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-OH SOMATOSTATIN-28 (1-14) SOMATOSTATIN-28 (1-12) SOMATOSTATIN-25 SOMATOSTATIN 28 Hexarelin Growth hormone releasing peptide 15-28-Somatostatin-28 GROWTH HORMONE, HUMAN TYR-SOMATOSTATIN-28 AGCKNFFWKTFTSC (DISULFIDE BRIDGE: 3-14), ACETATE SALT

  • Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH
  • SoMatotropin Release-Inhibiting Factor, SRIF, SRIF-14
  • Cyclic somatostatin
  • SoMatostatin Acetat
  • GROWTH HORMONE RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE)
  • GROWTH HORMONE RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O
  • H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH
  • H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (COUPLED TO BSA)
  • H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (COUPLED TO KLH)
  • H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH, CYS3,14, CYCLIC
  • H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (DISULFIDE BRIDGE: 3-14)
  • GIF (HUMAN, OVINE, PORCINE, RAT, MOUSE)
  • GIF (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O
  • GH-RIF
  • ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-PHE-THR-SER-CYS-OH
  • ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS
  • ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS 2ACOH 6H2O
  • AGCKNFFWKTFTSC
  • AGCKNFFWKTFTSC (DISULFIDE BRIDGE: 3-14)
  • SOMATOSTATIN-14
  • SOMATOSTATIN-14 (COUPLED TO BSA)
  • SOMATOSTATIN-14 (COUPLED TO KLH)
  • SOMATOSTATIN-14 (REDUCED)
  • SOMATOSTATIN ACETATE
  • SOMATOSTATIN, CYCLIC
  • SOMATOSTATIN [D-TRP8]
  • SOMATOSTATIN [GIF]
  • SOMATOSTATIN (HUMAN, OVINE, PORCINE, RAT, MOUSE)
  • SOMATOSTATIN (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O
  • SOMATOSTATIN, SHEEP
  • SOMATOSTATIN [TYR1]
  • SOMATOTROPIN RELEASE INHIBITING FACTOR
  • SOMATOTROPIN RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE)
  • SOMATOTROPIN RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O
  • SRIF
  • Growth hormone-release inhibiting factor: L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide
  • Somatostatina
  • Somatostatina [inn-spanish]
  • Somatostatine
  • Growth hormone release inhibiting factor Somatotropin release inhibiting factor
  • SRIF-14;SOMATOSTATIN-14
  • Cyclic somatostatin (SRIF-14
  • Somatostatin-14, ≥97% (HPLC)
  • SRIF (HUMAN, OVINE, PORCINE, RAT, MOUSE)
  • SRIF (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O
  • H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bond)
  • somatostatin gamma-irradiated*cell culture tested
  • SOMATOSTATIN, CELL CULTURE TESTED
  • Growth hormone-releasing inhibiting factor
  • Argirelin Acetate
  • Somastostatin Acetate
  • Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH, (Disulfide Bridge3:14)
  • 15-28-Somatostatin-28
  • Synthetic cyclic growth hormone release-inhibiting factor
  • Synthetic somatostatin-14
  • Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge Cys3-Cys14)
  • H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH acetate salt (Disulfide bond)
  • SOMATOSTATIN PH. EUR.