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Ethyl diethoxyphosphinylformate

Product Name
Ethyl diethoxyphosphinylformate
CAS No.
1474-78-8
Chemical Name
Ethyl diethoxyphosphinylformate
Synonyms
Foscarnet EP Impurity D;Foscarate EP Impurity D;Foscarnet impurity D CRS;TRIETHYL PHOSPHONOFORMATE;Triethyl carboxyphosphonate;Triethyl phosphonomethanoate;Foscarnet Related CoMpound D;Diethyl carbethoxyphosphonate;TRIETHYL PHOSPHONOFORMATE 98%;Foscarnet Sodium EP Impurity D
CBNumber
CB6423762
Molecular Formula
C7H15O5P
Formula Weight
210.16
MOL File
1474-78-8.mol
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Ethyl diethoxyphosphinylformate Property

Boiling point:
135 °C12 mm Hg(lit.)
Density 
1.11 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.423(lit.)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
Chloroform (Slightly), Methanol (Slightly)
color 
Colorless to Almost colorless
Specific Gravity
1.11
BRN 
1781949
Stability:
Moisture Sensitive
CAS DataBase Reference
1474-78-8(CAS DataBase Reference)
NIST Chemistry Reference
Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide(1474-78-8)
EPA Substance Registry System
Phosphinecarboxylic acid, diethoxy-, ethyl ester, oxide (1474-78-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-43
Safety Statements 
24/25-36/37-26-37-24
WGK Germany 
3
TSCA 
Yes
HS Code 
2931 39 90
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2870
Product name
Foscarnet Related Compound D
Purity
pharmaceutical secondary standard, certified reference material
Packaging
0.5ML
Price
$634
Updated
2024/03/01
Sigma-Aldrich
Product number
1283324
Product name
Foscarnet Related Compound D
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
0.27ml
Price
$1140
Updated
2024/03/01
TCI Chemical
Product number
E0400
Product name
Ethyl Diethoxyphosphinylformate
Packaging
25g
Price
$40
Updated
2024/03/01
Alfa Aesar
Product number
B23367
Product name
Ethyl diethoxyphosphinylformate, 97+%
Packaging
25g
Price
$16.7
Updated
2021/12/16
Alfa Aesar
Product number
B23367
Product name
Ethyl diethoxyphosphinylformate, 97+%
Packaging
100g
Price
$46.4
Updated
2021/12/16
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Ethyl diethoxyphosphinylformate Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to slightly yellow liquid

Uses

Diethyl (Ethoxycarbonyl)phosphonate is an impurity in the synthesis of Foscarnet (F727400), an inhibitor of viral DNA polymerase and reverse transcriptase. Foscarnet is used as an antiviral.

General Description

for synthesis

Purification Methods

Dissolve it in Et2O, shake this with H2O (to remove any trace of NaCl impurity), dry (Na2SO4), evaporate and distil it using an efficient fractionating column. [Nylén Chem Ber 57 1035 1924, Reetz et al. J Am Chem Soc 77 3813 1955, Monson Advanced Organic Synthesis Academic Press p 89 1972, Beilstein 3 II 103.]

Ethyl diethoxyphosphinylformate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl diethoxyphosphinylformate Suppliers

Toronto Research Chemicals Inc.
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6668
Advantage
58
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View Lastest Price from Ethyl diethoxyphosphinylformate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Ethyl diethoxyphosphinylformate 1474-78-8
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-07-26
Shaanxi Dideu Medichem Co. Ltd
Product
Triethyl Phosphonoformate 1474-78-8
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2020-01-14
Career Henan Chemical Co
Product
Ethyl diethoxyphosphinylformate 1474-78-8
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
500kg
Release date
2019-12-31

1474-78-8, Ethyl diethoxyphosphinylformateRelated Search:


  • Diethyl carbethoxyphosphonate
  • Diethyl ethoxycarbonylphosphonate
  • Ethyl diethoxyphosphinecarboxylate oxide
  • Formic acid, phosphono-, triethyl ester
  • phosphinecarboxylicacid,diethoxy-,ethylester,oxide
  • Triethyl carboxyphosphonate
  • Triethyl phosphonomethanoate
  • (ETHOXYCARBONYL)PHOSPHONIC ACID DIETHYL ESTER
  • ETHYL DIETHOXYPHOSPHINYLFORMATE
  • DIETHOXYPHOSPHINYLFORMIC ACID ETHYL ESTER
  • TRIETHYL PHOSPHONOFORMATE
  • TRIETHYL PHOSPHONOFORMATE 98%
  • PhosphonoformicacidTriethylester
  • Foscarnet Sodium EP Impurity D
  • Foscarnet Sodium Impurity 4(Foscarnet Sodium EP Impurity D)
  • Ethyl diethoxyphosphinylformate,98%
  • TRIETHYL PHOSPHONOFORMATE (ETHYL DIETHOXYPHOSPHINILFORMATE)
  • ethyl diethyl-phosphonoformate
  • ETHYL DIETHOXYPHOSPHINYLFORMATE (TRIETHYL PHOSPHONOFORMATE)
  • Foscarnet Related Compound D (0.27 mL) (O,O-diethyl ethoxycarbonylphosphonate)
  • Diethoxyphosphinylformic Acid Ethyl Ester (Ethoxycarbonyl)phosphonic Acid Diethyl Ester Triethyl Phosphonoformate
  • Foscarnet Related CoMpound D
  • Ethyl diethoxyphospinylformate
  • Foscarnet impurity D CRS
  • Foscarnet EP Impurity D
  • Phosphinecarboxylic acid, 1,1-diethoxy-, ethyl ester, 1-oxide
  • Foscarnet Related Compound D (O,O-diethyl ethoxycarbonylphosphonate) (1283324)
  • Foscarnet USP Related Compound D
  • Foscarnet Sodium Hexahydrate Impurity D
  • Foscarnet Sodium Hexahydrate EP Impurity D
  • Foscarnet Sodium EP Impurity D (Foscarnet USP Related Compound D)
  • Foscarate EP Impurity D
  • 1474-78-8
  • C2H5O2POCOOC2H5
  • C7H15O5P
  • Building Blocks
  • Phosphorus Compounds
  • Phosphonates/Phosphinates
  • Organic Building Blocks
  • Organic Building Blocks
  • Phosphonates/Phosphinates
  • Phosphorus Compounds