4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
- Product Name
- 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
- CAS No.
- 120278-07-1
- Chemical Name
- 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
- Synonyms
- N-CBZ-4-aMinepiperidin;4-Amino-1-Z-piperidine;N-CBZ-4-aminepiperidine;1-CBZ-4-AMINOPIPERIDINE;1-N-CBZ-4-AMINO-PIPERIDINE;4-AMINO-1-N-CBZ-PIPERIDINE;4-Amino-1-carbobenzoxypiperidine;4-Amino-1-Cbz-piperidine - [A12336];4-Amino-1-benzyloxycarbonylpiperidine;Benzyl 4-aminopiperidine-1-carboxylate
- CBNumber
- CB6427902
- Molecular Formula
- C13H18N2O2
- Formula Weight
- 234.29
- MOL File
- 120278-07-1.mol
4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Property
- Melting point:
- 68 °C(dec.)
- Boiling point:
- 367.2±42.0 °C(Predicted)
- Density
- 1.151±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to lump
- pka
- 10.07±0.20(Predicted)
- color
- White to Light yellow
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C13H18N2O2/c14-12-6-8-15(9-7-12)13(16)17-10-11-4-2-1-3-5-11/h1-5,12H,6-10,14H2
- InChIKey
- YYIQGSYCCNQAGV-UHFFFAOYSA-N
- SMILES
- N1(C(OCC2=CC=CC=C2)=O)CCC(N)CC1
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-37-60
- RIDADR
- UN3259
- HazardClass
- 8
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A2756
- Product name
- 4-Amino-1-carbobenzoxypiperidine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- A2756
- Product name
- 4-Amino-1-carbobenzoxypiperidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $110
- Updated
- 2025/07/31
- Product number
- A605145
- Product name
- 4-Amino-1-N-Cbz-piperidine
- Packaging
- 5g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- J95005
- Product name
- 4-Amino-1-N-Cbz-piperidine
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 074761
- Product name
- 1-N-Cbz-4-Aminopiperidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $44
- Updated
- 2021/12/16
4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Chemical Properties,Usage,Production
Uses
It is an important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.
Synthesis
159874-20-1
120278-07-1
General procedure for the synthesis of 1-Cbz-4-aminopiperidine (benzyl 4-aminopiperidine-1-carboxylate) from 1-Cbz-4-BOC-aminopiperidine: 4-(N-BOC amino)-Cbz piperidine (24.4 kg, 73.42 mol), THF (65 kg), and 5M HCl (23.0 kg, 110.13 mol) were mixed and heated to 30-35 °C for 2 h. The reaction was then continued at 55 °C overnight. After completion of the reaction, the mixture was cooled to 100 °C and dichloromethane (97 kg) and 10 M NaOH (7.97 kg, 145.12 mol) were added, controlling the temperature below 25 °C. After partitioning, the organic phase was washed with 25 wt% NaCl solution (27.5 kg). The washed organic phase was concentrated by distillation at atmospheric pressure to a volume of about 70 L. Subsequently, dichloromethane (162 kg) was added and concentrated by distillation again to a volume of about 120 L to give a dichloromethane solution of the title product 1-Cbz-4-aminopiperidine (17.2 kg, 100% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 7.33 (5H, m), 5.14 (2H, s), 4.14 (2H, br s), 2.87 (3H, m), 1.83 (2H, m), 1.66 (3H, m), 1.28 (2H, m).
References
[1] Patent: WO2009/91856, 2009, A2. Location in patent: Page/Page column 63-64
4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER manufacturers
- Product
- 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER 120278-07-1
- Price
- US $1.80-3.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 88KG
- Release date
- 2019-09-04