OXYTHIAMINE HYDROCHLORIDE

Product Name: OXYTHIAMINE HYDROCHLORIDE
CAS No.: 136-16-3
Chemical Name: OXYTHIAMINE HYDROCHLORIDE
Synonyms: azolium;oxythiamin;oxythiamine;Hydroxythiamin;oxythiamine(1+);OXYTHIAMINE HCL;Thiamine Impurity 19;OXYTHIAMINE HYDROCHLORIDE;Oxythiamine·HCl≥ 99% (assay);Oxythiamine (Hydroxythiamin)
CBNumber: CB6428626
Molecular Formula: C12H17Cl2N3O2S
Formula Weight: 338.25
MOL File: 136-16-3.mol

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OXYTHIAMINE HYDROCHLORIDE Property

Density: 1.2416 (rough estimate)
refractive index: 1.6740 (estimate)
storage temp.: −20°C
solubility: DMSO : 51.67 mg/mL (194.00 mM)
form: Solid
color: White to off-white

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Safety

WGK Germany: 3
RTECS: XJ7034100
Toxicity: LD50 scu-mus: 1430 mg/kg PCJOAU16,848,82

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Chem-Impex

Product number: 09663
Product name: Oxythiamine HCl
Purity: ≥ 95% (TLC)
Packaging: 5G
Price: $60
Updated: 2021/12/16

Chem-Impex

Product number: 09663
Product name: Oxythiamine HCl
Purity: ≥ 95% (TLC)
Packaging: 25G
Price: $200
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb572997
Product name: Oxythiamine
Purity: >98%
Packaging: 100mg
Price: $277.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb572997
Product name: Oxythiamine
Purity: >98%
Packaging: 250mg
Price: $414.8
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb572997
Product name: Oxythiamine
Purity: >98%
Packaging: 1g
Price: $615.4
Updated: 2021/12/16

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OXYTHIAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Oxythiamine (Hydroxythiamin), an analogue of anti-metabolite, can suppress the non-oxidative synthesis of ribose and induce cell apoptosis. Oxythiamine is a thiamine antagonist and inhibits transketolase (TK). Oxythiamine inhibits cancer cell apoptosis and inhibits cell proliferation[1][2][3].

Definition

ChEBI: A 1,3-thiazolium cation that is 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole alkylated at the N3 position by a (2-methyl-4-oxo-1,4-dihydropyrimidin-5-yl)methyl group.

Safety Profile

Moderately toxic by subcutaneous route. Experimental reproductive effects. Whenheated to decomposition it emits toxic fumes of NOx and SOx.

in vivo

Oxythiamine (100-500 mg/kg, i.p. 4 days) inhibits tumor growth in Ehrlich's ascites tumor hosting mice^[2].
Oxythiamine (250 or 500 mg/kg, daily for 5 week) inhibits tumor cell metastasis via inhibition of MMPs in mice implanted (s.c.) with LLC cells^[4].

Animal Model:	Ehrlich's ascites tumor hosting mice^[2]
Dosage:	100-500 mg/kg
Administration:	i.p., 4 days
Result:	Inhibited tumor growth by 43% at 300 mg/kg and 84% at 500 mg/kg.

References

[1] Wang J, et al. Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells. Exp Hematol Oncol. 2013 Jul 27;2:18. DOI:10.1186/2162-3619-2-18
[2] Ra?s B, et al. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle. FEBS Lett. 1999 Jul 30;456(1):113-8. DOI:10.1016/s0014-5793(99)00924-2
[3] Bai L, et al. A dose- and time-dependent effect of oxythiamine on cell growth inhibition in non-small cell lung cancer. Cogn Neurodyn. 2022 Jun;16(3):633-641. DOI:10.1007/s11571-021-09725-7
[4] Yang CM, et al. The in vitro and in vivo anti-metastatic efficacy of oxythiamine and the possible mechanisms of action. Clin Exp Metastasis. 2010 May;27(5):341-9. DOI:10.1007/s10585-010-9331-2

OXYTHIAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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OXYTHIAMINE HYDROCHLORIDE Suppliers

China 19 Germany 1 Switzerland 1 United Kingdom 1 United States 5 Global 27

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136-16-3, OXYTHIAMINE HYDROCHLORIDERelated Search:

OXYTHIAMINE HYDROCHLORIDE 5-(2-Hydroxyethyl)-4-methylthiazole 5-METHYLPYRIMIDIN-4-OL 5-PYRIMIDINEMETHANAMINE 4-HYDROXY-2-METHYLPYRIMIDINE 5-ethyl-4-methylthiazole 5-Pyrimidinemethanamine, 2-methyl- (9CI) 4-Pyrimidinol, 2,5-dimethyl- (7CI,9CI) OXYTHIAMINE HYDROCHLORIDE

Thiazolium,3-[(3,4-dihydro-2-methyl-4-oxo-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-

Oxythiamine·HCl≥ 99% (assay)

oxythiamine(1+)

Oxythiamine (Hydroxythiamin)

Oxythiamine (Synonyms: Hydroxythiamin)

thiazolium,5-(2-hydroxyethyl)-3-((4-hydroxy-2-methyl-5-pyrimidinyl)methyl)-4-m

5-(2-HYDROXYETHYL)-3-(4-HYDROXY-2-METHYL-5-PYRIMIDINYLMETHYL)-4-METHYLTHIAZOLIUM CHLORIDE

5-[2-HYDROXYETHYL]-3-[4-HYDROXY-2-METHYL-5-PYRIMIDINYLMETHYL]-4-METHYLTHIAZOLIUM CHLORIDE HYDROCHLORIDE

5-(2-hydroxyethyl)-3-((4-hydroxy-2-methyl-5-pyrimidinyl)methyl)-4-methyl-thi

azolium

oxythiamin

oxythiamine

3-[(1,4-Dihydro-2-methyl-4-oxopyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methylthiazol-3-ium

3-[(3,4-Dihydro-2-methyl-4-oxopyrimidine-5-yl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium

5-(2-Hydroxyethyl)-3-[(4-hydroxy-2-methyl-5-pyrimidinyl)methyl]-4-methylthiazol-3-ium

OXYTHIAMINE CHLORIDE HYDROCHLORIDE

OXYTHIAMINE HCL

OXYTHIAMINE HYDROCHLORIDE

Hydroxythiamin

Oxythiamine DISCONTINUED. Please see O878508.

Thiamine Impurity 19

Thiamine Impurity 19 Monomer (Oxythiamine Monomer)

136-16-3

C12H15N3O2SHCl

C12H16N3O2S